[1]付 钰,束明阳,杨 波.即刻种植联合富血小板纤维蛋白固定种植体在前牙缺失治疗中的疗效及对患者龈沟液骨桥蛋白的影响[J].陕西医学杂志,2024,(1):51-54.[doi:DOI:10.3969/j.issn.1000-7377.2024.01.011]
　FU Yu,SHU Mingyang,YANG Bo.Efficacy of immediate implantation combined with PRF in immediate implantation of anterior teeth loss and the influence of OPN level in gingival crevicular fluid[J].,2024,(1):51-54.[doi:DOI:10.3969/j.issn.1000-7377.2024.01.011]
点击复制

即刻种植联合富血小板纤维蛋白固定种植体在前牙缺失治疗中的疗效及对患者龈沟液骨桥蛋白的影响
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2024年1期
页码:
51-54
栏目:
临床研究
出版日期:
2024-01-31

文章信息/Info

Title:
Efficacy of immediate implantation combined with PRF in immediate implantation of anterior teeth loss and the influence of OPN level in gingival crevicular fluid
作者:
付 钰; 束明阳; 杨 波
(淮安市第二人民医院口腔科,江苏 淮安 223000)
Author(s):
FU Yu; SHU Mingyang; YANG Bo
(Department of Stomatology,Huai'an Second People's Hospital,Huai'an 223000,China)
关键词:
即刻种植;  富血小板纤维蛋白;  前牙缺失;  骨桥蛋白;  龈沟液;  疗效
Keywords:
Immediate implantation;  Platelet-rich fibrin;  Anterior teeth loss;  Osteopontin;  Gingival crevicular fluid;  Efficacy
分类号:
R 783.4
DOI:
DOI:10.3969/j.issn.1000-7377.2024.01.011
文献标志码:
A
摘要:
目的:探究即刻种植联合使用患者富血小板纤维蛋白(PRF)固定种植体在前牙缺失治疗中的疗效及对患者龈沟液骨桥蛋白(OPN)水平的影响。方法:选择前牙缺失患者82例,依照随机数字表法分为两组各41例,对照组即刻种植,观察组在对照组基础上联合PRF。对比两组总有效、OPN、碱性磷酸酶(ALP)、骨保护素(OPG)、软垢指数、龈沟出血指数、菌斑指数、种植体周围骨密度、唇腭向骨厚度、唇腭向骨高度。结果:观察组总有效率高于对照组(P<0.05)。术前,两组OPN、ALP、OPG比较,无统计学差异(均P>0.05); 术后30 d,观察组OPN、ALP水平及软垢、龈沟出血、菌斑指数较对照组降低,而OPG高于对照组(均P<0.05)。在术后6、12周,观察组种植体周围骨密度、唇腭向骨厚度、唇腭向骨高度高于对照组(均P<0.05)。结论:即刻种植联合使用PRF在前牙缺失即刻种植中具有较为理想疗效,有利于改善骨代谢。
Abstract:
Objective:To investigate the efficacy of immediate implantation combined with platelet-rich fibrin(PRF)in anterior tooth loss and the influence on osteopontin(OPN)level in gingival crevicular fluid.Methods:A total of 82 patients with anterior tooth loss were selected,and 41 cases were divided into the control group(immediate implantation)and the observation group combined with PRF on the basis of the control group.Total effective rate,OPN,alkaline phosphatase(ALP),osteopultin(OPG),soft scale index,gingival sulcus bleeding index,plaque index,periimplant bone mineral density,labiopalatine bone thickness and labiopalatine bone height were compared.Results:The total effective rate of observation group was higher than that of control group(P<0.05).Before operation,there were no significant differences in OPN,ALP and OPG between the two groups(all P>0.05).30 days after operation,OPN and ALP levels,soft scale,gingival sulcus bleeding and plaque index in observation group were lower than those in control group,while OPG was higher than that in control group(all P<0.05).At 6 and 12 weeks after surgery,the bone density,labiopalatine bone thickness and labiopalatine bone height around the implant in the observation group were higher than those in the control group(all P<0.05).Conclusion:Immediate implantation combined with PRF has an ideal effect in immediate implantation of missing anterior teeth,which is beneficial to improve bone metabolism.

参考文献/References:

[1] 闫慧鑫,孟文侠,牛玉岚.口腔种植覆盖义齿与全口义齿修复牙列缺失效果对比研究[J].陕西医学杂志,2022,51(9):1122-1124,1128.
[2] 刘磊,吕东达.口腔种植修复技术对慢性牙周炎患者种植体松动度、PD及SBI指数影响研究[J].陕西医学杂志,2018,47(3):305-307.
[3] FANG J,XIN XR,LI W,et al.Immediate implant placement in combination with platelet rich-fibrin into extraction sites with periapical infection in the esthetic zone:A case report and review of literature[J].World J Clin Cases,2021,9(4):960-969.
[4] 闫娜,黄涛,张中月,等.富血小板纤维蛋白联合GBR技术在种植体周围炎骨缺损重建的临床应用[J].实用医学杂志,2020,36(6):813-817.
[5] 胥阳,刘学,闫巍.布洛芬派力奥缓释凝胶联合富血小板纤维蛋白用于年轻恒牙脱位再植的研究[J].河北医药,2021,43(16):2432-2435,2441.
[6] LIU K,ZHENG C,ZHANG Z,et al.Platelet-rich fibrin/anorganic bovine bone mineral complex as grafting materials in endodontic microsurgery with a large lesion size:Study protocol for a randomised controlled trial[J].BMJ Open,2022,12(4):940-948.
[7] 中国人体健康科技促进会妇科内分泌和生育力促进分会,中国女医师协会输血专业委员会.自体富血小板纤维蛋白(PRF)治疗宫腔粘连专家共识[J].临床输血与检验,2022,24(3):279-284.
[8] 陈冲,热依拉?艾克兰木,冷春涛,等.即刻种植及残根保存修复治疗前牙残根Ⅴ类缺损的疗效观察[J].口腔颌面修复学杂志,2022,23(5):337-341.
[9] 仲琳,何辰菲,魏明贵,等.牙周病患者前牙即刻种植和常规种植修复2年内稳定性比较[J].上海口腔医学,2022,31(3):309-312.
[10] 任伶,韩晓辉,侯亚丽,等.上颌前牙区即刻种植即刻修复患者唇侧骨板影像学变化及护理[J].医学影像学杂志,2022,32(5):761-764.
[11] LAURA-MORALES F N,PEDRO T,MART-IBARZ B,et al.Anterior-segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C:Morphological analysis and correlation with intraocular pressure reduction[J].Acta Ophthalmologica,2022,100(1):192-203.
[12] 李峥,李荣华.富血小板纤维蛋白在牙周炎治疗中的应用研究[J].国际生物医学工程杂志,2021,44(5):383-387.
[13] 刘亮亮,王宁,仲维剑,等.改良型富血小板纤维蛋白在上颌窦底提升术中成骨效果的临床研究[J].中国实用口腔科杂志,2023,16(1):76-81.
[14] 徐济群,胡茂能,黄伟,等.富血小板纤维蛋白在伴有骨缺损的牙即刻种植中的临床应用[J].蚌埠医学院学报,2021,46(12):1684-1687.
[15] LIANG Z,HUANG D,NONG W H,et al.Advanced-platelet-rich fibrin extract promotes adipogenic and osteogenic differentiation of human adipose-derived stem cells in a dose-dependent manner in vitro[J].Tissue and Cell,2021,71(12):101506.
[16] HÜSEYIN SARI,KARAKETIR S,KUMRAL T L,et al.The effect of platelet-rich fibrin(PRF)on wound healing,adhesion,and hemostasis after endoscopic sinus surgery in patients with nasal polyposis[J].American Journal of Otolaryngology,2021,42(5):103010.
[17] 刘骏,李桂丛,李晓光.康复新液联合裸花紫珠胶囊治疗口腔种植体周围软组织炎临床研究[J].陕西中医,2021,42(6):754-756.
[18] 周峰,祝岩.补肾扶脾汤治疗口腔种植体周围炎疗效及对患者龈沟液IL-1β、IL-6的影响[J].陕西中医,2018,39(8):1101-1104.
[19] 徐伟成,张志军,王聃.微创拔牙联合富血小板纤维蛋白在即刻种植中效果及预后影响因素[J].临床口腔医学杂志,2022,38(9):541-545.
[20] 梁学进,柴红波,倪小兵.自体牙-骨移植联合富血小板纤维蛋白影响种植体周围缺损的机制[J].医学分子生物学杂志,2022,19(3):240-245.
[21] 黄徐琛,高琴.Bio-Oss骨粉联合PRF及GBR技术对种植体周围骨再生及种植体周围炎的影响[J].河北医学,2023,29(2):275-280.
[22] 李瑾,高冬玲,李杨.CDA/CAM牙种植导板在上前牙列缺失即刻种植修复中的应用[J].陕西医学杂志,2020,49(11):1451-1460.
[23] 黄仙波,何志良,曹雷,等.A-PRF联合Bio-Oss对种植体周围骨缺损的修复效果实验研究[J].临床误诊误治,2023,36(4):136-141.
[24] 陆建荣,班华杰.富血小板纤维蛋白在拔牙后即刻种植术中的应用效果研究[J].广西医科大学学报,2022,39(7):1159-1162.

备注/Memo

备注/Memo:
基金项目:江苏省自然科学基金资助项目(BK20191103)
更新日期/Last Update: 2024-01-05