[1]廖莹莹,张荣臻,舒发明,等.硒在慢性肝病中的作用研究进展[J].陕西医学杂志,2023,52(12):1782-封3.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.034]
　LIAO Yingying,ZHANG Rongzhen,SHU Faming,et al.Research progress on role of selenium in chronic liver disease[J].,2023,52(12):1782-封3.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.034]
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硒在慢性肝病中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年12期
页码:
1782-封3
栏目:
综 述
出版日期:
2023-12-05

文章信息/Info

Title:
Research progress on role of selenium in chronic liver disease
作者:
廖莹莹1; 张荣臻2; 舒发明2; 毛德文2
(1.广西中医药大学,广西 南宁 530001; 2.广西中医药大学第一附属医院,广西 南宁 530022)
Author(s):
LIAO Yingying; ZHANG Rongzhen; SHU Faming; MAO Dewen
(Guangxi University of Chinese Medicine,Nanning 530001,China)
关键词:
硒;  慢性肝炎;  非酒精性脂肪性肝病;  肝纤维化;  肝细胞癌
Keywords:
Selenium;  Chronic hepatitis;  Non-alcoholic fatty liver disease;  Liver fibrosis;  Hepatocellular carcinoma
分类号:
R 575
DOI:
DOI:10.3969/j.issn.1000-7377.2023.12.034
文献标志码:
A
摘要:
硒是人体必需的微量元素之一,在人体中的平衡摄入和代谢对维持身体健康和预防疾病至关重要。最近的研究表明,肝脏作为能量代谢的中枢器官,其功能的正常和疾病的发生与硒密切相关。硒通过肝脏内的硒蛋白酶催化发挥其生物学功能,与慢性肝炎、肝纤维化、非酒精性脂肪性肝病、肝细胞癌密切相关。现将对硒在慢性肝病的作用进行综述,总结其特点与机制,为慢性肝病的治疗提供新思路和方向。
Abstract:
Selenium is one of the essential trace elements in the human body,and its balanced intake and metabolism are crucial to maintaining good health and preventing disease.Recent studies have shown that the liver,as a central organ for energy metabolism,is closely related to selenium in its normal function and disease occurrence.Selenium exerts its biological functions through selenoproteins in the liver and is closely related to chronic hepatitis,liver fibrosis,metabolic-associated fatty liver disease,and hepatocellular carcinoma.There have been new developments in research on the trace element selenium both domestically and internationally.This article reviews the role of selenium in chronic liver disease,summarizes its characteristics and mechanisms,and provides new ideas and directions for the treatment of chronic liver disease.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81960841,82274434); 广西壮族自治区中医药多学科交叉创新团队建设项目(GZKJ2306); 广西中医药大学研究生教育创新计划项目(YCSY2022024,YCSW2023378)
更新日期/Last Update: 2023-12-05