[1]钟 倩,吴洪瀚,吴恒鹏,等.前列腺癌转基因动物模型研究进展[J].陕西医学杂志,2023,52(12):1778-1781.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.033]
 ZHONG Qian,WU Honghan,WU Hengpeng,et al.Research progress in transgenic animal models of prostate cancer[J].,2023,52(12):1778-1781.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.033]
点击复制

前列腺癌转基因动物模型研究进展
分享到:

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年12期
页码:
1778-1781
栏目:
综 述
出版日期:
2023-12-05

文章信息/Info

Title:
Research progress in transgenic animal models of prostate cancer
作者:
钟 倩吴洪瀚吴恒鹏陈 伟方 琴瓦庆德
(遵义医科大学第二附属医院,贵州 遵义 563000)
Author(s):
ZHONG QianWU HonghanWU HengpengCHEN WeiFANG QinWA Qingde
(The Second Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
关键词:
前列腺癌 转基因 动物模型 癌基因 抑癌基因
Keywords:
Prostate cancer Transgenic Animal model Oncogene Tumor suppressor gene
分类号:
R 737.25
DOI:
DOI:10.3969/j.issn.1000-7377.2023.12.033
文献标志码:
A
摘要:
前列腺癌的发病与基因异常变化密切相关,大量前列腺癌患者存在多种癌基因和抑癌基因突变。前列腺癌转基因动物模型的优势在于用重组DNA的方法导入外源基因后能自主调控基因表达,进而控制疾病特征。因此,该肿瘤模型与人体肿瘤的组织病理学及分子特征高度相似,其能模仿前列腺癌的发生、发展等病理过程,有望提高对前列腺癌的认识并为寻求新型治疗方法提供重要研究手段。现就常用的前列腺癌转基因动物模型进行介绍。
Abstract:
The occurrence of prostate cancer is closely related to abnormal gene changes.Numerous patients with prostate cancer have a variety of oncogene and tumor-suppressor gene mutations.The advantage of transgenic animal models of prostate cancer lies in that they can autonomously regulate gene expressions and thereby control disease characteristics after introducing exogenous genes with recombinant DNA.Therefore,such tumor models are highly similar to the histopathological and molecular characteristics of human tumors.They can simulate the occurrence and development of prostate cancer and are expected to improve the understanding of prostate cancer and provide an important research means for exploring novel treatment methods.This article reviews the commonly used transgenic animal models of prostate cancer.

参考文献/References:

[1] 雒向宁,王文娟,李 凯,等.去甲斑蝥素对雄激素非依赖型前列腺癌PC-3细胞增殖、凋亡的影响[J].陕西医学杂志,2020,8(4):928-931,939.
[2] 中国抗癌协会泌尿男生殖系肿瘤专业委员会,中国临床肿瘤学会前列腺癌专家委员会.中国前列腺癌患者基因检测专家共识(2020年版)[J].中国癌症杂志,2020,30(7):551-560.
[3] Civenni G,Carbone GM,Catapano CV.Overview of genetically engineered mouse models of prostate cancer and their applications in drug discovery[J].Current Protocols in Pharmacology,2018,81(1):e39.
[4] Nascimento-Goncalves E,Faustino-Rocha AI,Seixas F,et al.Modelling human prostate cancer:Rat models[J].Life Sciences,2018,203:210-224.
[5] Berish RB,Ali AN,Telmer PG,et al.Translational models of prostate cancer bone metastasis[J].Nature Reviews Urology,2018,15(7):403-421.
[6] Mai CW,Chin KY,Foong LC,et al.Modeling prostate cancer:What does it take to build an ideal tumor model?[J].Cancer Letters,2022,543:215794.
[7] Deborah LB,Katherine LM,Anjali VS,et al.The role of rb in prostate cancer progression[J].Adv Exp Med Biol,2019,1210:301-318.
[8] Chuan Y,Kevin H,Daniel N,et al.From genomics to functions:Preclinical mouse models for understanding oncogenic pathways in prostate cancer[J].Am J Cancer Res,2019,9(10):2079-2102.
[9] Adamiecki R,Hryniewicz-Jankowska A,Ortiz MA,et al.In vivo models for prostate cancer research[J].Cancers,2022,14(21):5321.
[10] Liu TT,Ewald JA,Ricke EA,et al.Modeling human prostate cancer progression in vitro[J].Carcinogenesis,2019,40(7):893-902.
[11] Kido LA,Almeida LC,Maróstica MR,et al.Transgenic adenocarcinoma of the mouse prostate(TRAMP)model:A good alternative to study PCa progression and chemoprevention approaches[J].Life Sciences,2019,217:141-147.
[12] Sun J,Bok RA,Delossantos J,et al.Resistance to androgen deprivation leads to altered metabolism in human and murine prostate cancer cell and tumor models[J].Metabolites,2021,11(3):139.
[13] Li W,Shen MM.Prostate cancer cell heterogeneity and plasticity:Insights from studies of genetically-engineered mouse models[J].Seminars in Cancer Biology,2022,82:60-67.
[14] Chen R,Liang X,Murray MM,et al.A simple quantitative PCR assay to determine TRAMP transgene zygosity[J].Prostate Cancer Prostatic Diseases,2021,24(2):358-361.
[15] Mateus PAM,Kido LA,Silva RS,et al.Association of anti-inflammatory and antiangiogenic therapies negatively influences prostate cancer progression in TRAMP mice[J].The Prostate,2019,79(5):515-535.
[16] Saranyutanon S,Deshmukh SK,Dasgupta S,et al.Cellular and molecular progression of prostate cancer:Models for basic and preclinical research[J].Cancers,2020,12(9):2651.
[17] Simons BW,Kothari V,Benzon B,et al.A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host[J].Oncotarget,2019,10(64):6845-6854.
[18] Juan MA,Cory AS.Genetically engineered mouse models of prostate cancer in the postgenomic era[J].Cold Spring Harb Perspect Med,2019,9(2):a030528.
[19] Unterberger CJ,Mcgregor SM,Kopchick JJ,et al.Mammary tumor growth and proliferation are dependent on growth hormone in female SV40 C3(1)T-antigen mice[J].Endocrinology,2023,164(2):174.
[20] Unterberger CJ,McIlwain SJ,Tsourkas PK,et al.Conditional gene regulation models demonstrate a pro-proliferative role for growth hormone receptor in prostate cancer[J].The Prostate,2023,83(5):416-429.
[21] Langston LD,Yuan Z,Georgescu R,et al.SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding[J].Proc Natl Acad Sci USA,2022,119(49):e2216240119.
[22] Moran NE,Thomas-Ahner JM,Wan L,et al.Tomatoes,lycopene,and prostate cancer:What have we learned from experimental models?[J].The Journal of Nutrition,2022,152(6):1381-1403.
[23] Zhang W,Weerden WM,Ridder CMA,et al.Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response[J].The Prostate,2019,79(4):390-402.
[24] Sedlack AJH,Saleh-Anaraki K,Kumar S,et al.Preclinical models of neuroendocrine neoplasia[J].Cancers,2022,14(22):5646.
[25] Okasho K,Mizuno K,Fukui T,et al.Establishment and characterization of a novel treatment-related neuroendocrine prostate cancer cell line KUCaP13[J].Cancer Science,2021,112(7):2781-2791.
[26] Arman T,Nelson PS.Endocrine and paracrine characteristics of neuroendocrine prostate cancer[J].Frontiers in Endocrinology,2022,13:1012005.
[27] Molter CW,Muszynski EF,Tao Y,et al.Prostate cancer cells of increasing metastatic potential exhibit diverse contractile forces,cell stiffness,and motility in a microenvironment stiffness-dependent manner[J].Frontiers in Cell and Developmental Biology,2022,10:932510.
[28] Khalil MI,Benedetti A.The TLK1-MK5 axis regulates motility,invasion,and metastasis of prostate cancer cells[J].Cancers,2022,14(23):5728.
[29] Anklesaria JH,Mhatre DR,Mahale SD.Structural and molecular biology of PSP94:Its significance in prostate pathophysiology[J].Frontiers in Bioscience(Landmark Edition),2018,23(3):535-562.
[30] Haughey CM,Mukherjee D,Steele RE,et al.Investigating radiotherapy response in a novel syngeneic model of prostate cancer[J].Cancers,2020,12(10):2804.
[31] Connelly ZM,Yang S,Chen F,et al.Foxa2 activates the transcription of androgen receptor target genes in castrate resistant prostatic tumors[J].American Journal of Clinical and Experimental Urology,2018,6(5):172-181.
[32] Elisia I,Yeung M,Wong J,et al.A low-carbohydrate diet containing soy protein and fish oil reduces breast but not prostate cancer in C3(1)/Tag mice[J].Carcinogenesis,2022,43(2):115-125.
[33] Varghese B,Lynch L,Vriend LE,et al.Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model[J].Cancer Immunol Immunother,2022,71(12):2943-2955.

相似文献/References:

[1]杜丽娜,康 峰△,苏燕胜,等.围术期常规干预联合下腹部局部热敷在前列腺癌电切术后排尿困难患者中的应用研究*[J].陕西医学杂志,2019,(6):784.
[2]雷 普,卢红梅,卜小斌,等.新型内分泌联合化疗治疗高危前列腺癌临床研究[J].陕西医学杂志,2021,50(4):454.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.018]
[3]贺 煜,常莉莉,潘治军.SPECT/CT联合血清游离前列腺特异性抗原/总前列腺特异性抗原检查对前列腺癌及骨转移的诊断价值[J].陕西医学杂志,2021,50(9):1102.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.015]
 HE Yu,CHANG Lili,PAN Zhijun.Diagnostic value of SPECT/CT combined with serum fPSA/tPSA in prostate cancer and bone metastasis[J].,2021,50(12):1102.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.015]
[4]代 佳,韩卫军,贺 林,等.术前血清磷酸甘油酸激酶1、髓样相关蛋白8/14水平与前列腺癌根治术患者预后和生存情况相关性研究[J].陕西医学杂志,2022,51(11):1389.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.016]
 DAI Jia,HAN Weijun,HE Lin,et al.Correlation between preoperative serum phosphoglycerate kinase 1,myeloid-associated protein 8/14 levels and prognosis and survival of patients undergoing radical prostatectomy[J].,2022,51(12):1389.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.016]
[5]王小禹,周 宁,黄 芩,等.蛋白精氨酸甲基转移酶5在前列腺癌组织中的表达及其与患者临床病理特征的关系[J].陕西医学杂志,2023,52(11):1602.[doi:DOI:10.3969/j.issn.1000-7377.2023.11.033]
 WANG Xiaoyu,ZHOU Ning,HUANG Qin,et al.Expression of arginine methyltransferase PRMT5 in prostate cancer tissues and its relationship with clinicopathological features of patients[J].,2023,52(12):1602.[doi:DOI:10.3969/j.issn.1000-7377.2023.11.033]
[6]马 俊,邵恩明,包 娟,等.长链非编码RNA LINC02587对前列腺癌细胞增殖和侵袭的影响及机制实验研究[J].陕西医学杂志,2024,(11):1443.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.001]
 MA Jun,SHAO Enming,BAO Juan,et al.Effect and mechanism of long non-coding RNA LINC02587 on the proliferation and invasion of prostate cancer cells[J].,2024,(12):1443.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.001]
[7]程树林,杜中波,黄 静,等.长链非编码RNA LINC00926调控微小RNA-331-3p对前列腺癌细胞增殖和迁移的影响[J].陕西医学杂志,2025,54(2):170.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.005]
 CHENG Shulin,DU Zhongbo,HUANG Jing,et al.Effect of lncRNA LINC00926 on the proliferation and migration of prostate cancer cells by regulating miR-331-3p[J].,2025,54(12):170.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.005]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82160577); 贵州省科技计划项目(黔科合基础-ZK[2021]重点007); 贵州省优秀青年科技人才培养项目(黔科合平台人才[2021]5613号)
更新日期/Last Update: 2023-12-05