[1]农金丽,杨培培,陈梓瑜,等.过氧化物酶体增殖物激活受体γ在膝骨关节炎中的作用研究进展[J].陕西医学杂志,2023,52(12):1770-1774.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.031]
 NONG Jinli,YANG Peipei,CHEN Ziyu,et al.Research progress on role of peroxisome proliferator-activated receptor γ in knee osteoarthritis[J].,2023,52(12):1770-1774.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.031]
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过氧化物酶体增殖物激活受体γ在膝骨关节炎中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年12期
页码:
1770-1774
栏目:
综 述
出版日期:
2023-12-05

文章信息/Info

Title:
Research progress on role of peroxisome proliferator-activated receptor γ in knee osteoarthritis
作者:
农金丽1杨培培2陈梓瑜1谭钦文1谭旭荣1张 也1崔洪运1王开龙2
(1.广西中医药大学,广西 南宁 530200; 2.广西中医药大学第一附属医院,广西 南宁 530022)
Author(s):
NONG JinliYANG PeipeiCHEN ZiyuTAN QinwenTAN XurongZHANG YeCUI HongyunWANG Kailong
(Guangxi University of Chinese Medicine,Nanning 530200,China)
关键词:
膝骨关节炎 过氧化物酶体增殖物激活受体γ 炎症因子 脂质代谢 细胞凋亡 自噬 血管生成
Keywords:
Knee osteoarthritis Peroxisome proliferator-activated receptor γ Inflammatory factors Lipid metabolism Cell apoptosis Autophagy Angiogenesis
分类号:
R 684.3
DOI:
DOI:10.3969/j.issn.1000-7377.2023.12.031
文献标志码:
A
摘要:
膝骨关节炎(KOA)是我国中老年人的常见病、高发病,致残率极高,其核心机制涉及炎症因子过度表达、软骨细胞凋亡、血管形成等多因素的相互作用。过氧化物酶体增殖激活性受体γ(PPARγ)是核激素受体家族中的配体诱导核受体中一个亚型,在抗KOA中具有抑制炎症因子、调控脂质代谢、抑制软骨细胞凋亡、抑制细胞自噬、抑制血管生成等关键作用。现从以上几个方面对PPARγ在KOA中的作用进行阐述。
Abstract:
Knee osteoarthritis(KOA)is a common disease in middle-aged and elderly people in China,with high incidence and high disability rate.Its core mechanism involves the interaction of multiple factors such as overexpression of inflammatory factors,apoptosis of chondrocytes and angiogenesis.Peroxisome proliferation-activated receptor γ(PPARγ)is a subtype of ligand-induced nuclear receptor in the nucleohormone receptor family,which plays a key role in anti-KOA,such as inhibiting inflammatory factors,regulating lipid metabolism,inhibiting chondrocyte apoptosis,inhibiting autophagy,and inhibiting angiogenesis.This article reviews the role of PPARγ in KOA from the above aspects.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82260961,82060902,81760887); 广西壮族自治区科技计划项目(桂科AB18126085)
更新日期/Last Update: 2023-12-05