[1]罗孔认,陈梦诗,陈珊娜.甲壳质酶蛋白40、中性粒细胞载脂蛋白及基质金属蛋白酶-9水平与尿毒症维持性血液透析患者感染相关性研究[J].陕西医学杂志,2023,52(10):1362-1366.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.017]
　LUO Kongren,CHEN Mengshi,CHEN Shanna.Correlation of YKL-40,NGAL and MMP-9 levels with infection in uremic patients undergoing maintenance hemodialysis[J].,2023,52(10):1362-1366.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.017]
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甲壳质酶蛋白40、中性粒细胞载脂蛋白及基质金属蛋白酶-9水平与尿毒症维持性血液透析患者感染相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年10期
页码:
1362-1366
栏目:
临床研究
出版日期:
2023-10-05

文章信息/Info

Title:
Correlation of YKL-40,NGAL and MMP-9 levels with infection in uremic patients undergoing maintenance hemodialysis
作者:
罗孔认; 陈梦诗; 陈珊娜
(海南医学院第一附属医院血液内科,海南 海口 570102)
Author(s):
LUO Kongren; CHEN Mengshi; CHEN Shanna
(Department of Hematology,First Affiliated Hospital of Hainan Medical College,Haikou 570102,China)
关键词:
尿毒症;  维持性血液透析;  感染;  甲壳质酶蛋白40;  中性粒细胞载脂蛋白;  基质金属蛋白酶-9
Keywords:
Uremia;  Maintenance hemodialysis;  Infection;  YKL-40;  NGAL;  MMP-9
分类号:
R 459.5
DOI:
DOI:10.3969/j.issn.1000-7377.2023.10.017
文献标志码:
A
摘要:
目的:探究血清甲壳质酶蛋白40(YKL-40)、中性粒细胞载脂蛋白(NGAL)、基质金属蛋白酶-9(MMP-9)水平与尿毒症维持性血液透析(MHD)患者感染的相关性。方法:选取尿毒症MHD患者120例,根据是否发生院内感染分为两组,感染组34例,非感染组86例,比较感染组感染部位及病原菌分布情况,比较两组一般临床资料及血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、YKL-40、NGAL、MMP-9表达水平,并分析YKL-40、NGAL、MMP-9在MHD患者感染中的应用价值。结果:感染组年龄、透析时间及血清CRP、IL-6、YKL-40、NGAL、MMP-9水平显著高于非感染组(均P<0.05); 经Logistic回归分析显示,YKL-40、NGAL、MMP-9水平是预测MHD感染的独立因素(均P<0.05)。YKL-40、NGAL、MMP-9诊断MHD感染的受试工作者特征曲线(ROC)的AUC分别为0.924、0.964、0.814,三者联合诊断MHD感染的AUC值为0.993,优于各单项指标。结论: YKL-40、NGAL、MMP-9水平升高是尿毒症MHD患者感染的独立危险因素,三者联合检测可提高MHD患者感染的诊断价值。
Abstract:
Objective:To analyze the correlation of serum levels of chitinase protein 40(YKL-40),neutrophil lipocalin(NGAL)and matrix metalloproteinase-9(MMP-9)with infection in patients with uremia maintenance hemodialysis(MHD).Methods:A total of 120 uremic MHD patients were selected and divided into two groups according to whether nosocomial infection occurred,34 cases in the infection group and 86 cases in the non-infection group.The infection site and pathogenic bacteria distribution of the infection group were analyzed.The general clinical data and serum levels of C-reactive protein(CRP),interleukin-6(IL-6),YKL-40,NGAL and MMP-9 were compared between the two groups.The application value of YKL-40,NGAL and MMP-9 in the infection of MHD patients was analyzed.Results:The age,dialysis time and serum levels of CRP,IL-6,YKL-40,NGAL and MMP-9 in infection group were significantly higher than those in non-infection group(all P<0.05).Logistic regression analysis showed that YKL-40,NGAL and MMP-9 levels were independent factors for predicting MHD infection(all P<0.05).The AUCs of receiver operating characteristic(ROC)curves of YKL-40,NGAL,and MMP-9 in the diagnosis of MHD infection were 0.924,0.964,and 0.814,respectively.The AUC value of the combined diagnosis of MHD infection was 0.993,which was better than each single indicator.Conclusion:The elevated levels of YKL-40,NGAL and MMP-9 are independent risk factors for infection in uremic MHD patients.The combined detection of YKL-40,NGAL and MMP-9 can improve the diagnostic value of infection in MHD patients.

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备注/Memo

备注/Memo:
基金项目:海南省卫生健康行业科研项目(22A200239)
更新日期/Last Update: 2023-10-07