[1]杨 佳,卢玉容,刘玉雄,等.中性粒细胞/淋巴细胞比值联合降钙素原、白细胞计数检测在小儿急性阑尾炎诊断及病情评估中的价值[J].陕西医学杂志,2023,52(8):1081-1084.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.032]
　YANG Jia,LU Yurong,LIU Yuxiong,et al.Value of neutrophil-to-lymphocyte ratio combined with PCT and WBC in diagnosis and evaluation of acute appendicitis in children[J].,2023,52(8):1081-1084.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.032]
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中性粒细胞/淋巴细胞比值联合降钙素原、白细胞计数检测在小儿急性阑尾炎诊断及病情评估中的价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年8期
页码:
1081-1084
栏目:
临床检验
出版日期:
2023-08-05

文章信息/Info

Title:
Value of neutrophil-to-lymphocyte ratio combined with PCT and WBC in diagnosis and evaluation of acute appendicitis in children
作者:
杨 佳; 卢玉容; 刘玉雄; 蔡 强
(宜宾市第二人民医院儿科,四川 宜宾 644004)
Author(s):
YANG Jia; LU Yurong; LIU Yuxiong; CAI Qiang
(Department of Pediatrics,the Second People's Hospital of Yibin,Yibin 644004,China)
关键词:
急性阑尾炎;  儿童;  诊断;  中性粒细胞/淋巴细胞比值;  降钙素原;  白细胞计数
Keywords:
Acute appendicitis;  Child;  Diagnosis;  Neutrophils-to-lymphocyte ratio;  Procalcitonin;  White blood cell count
分类号:
R 726
DOI:
DOI:10.3969/j.issn.1000-7377.2023.08.032
文献标志码:
A
摘要:
目的:探究中性粒细胞/淋巴细胞比值(NLR)联合降钙素原(PCT)、白细胞计数(WBC)检测在小儿急性阑尾炎(AA)诊断及病情评估中的应用价值。方法:回顾性选取157例AA患儿为观察组,根据手术病理检查结果将患儿分为单纯AA组(n=35)、化脓性AA组(n=75)、穿孔坏疽性AA组(n=47),另选取同期于本院就诊的102例非AA腹痛患儿为对照组,比较各组一般资料、NLR、PCT和WBC水平,受试者工作特征(ROC)曲线评估NLR、PCT和WBC对小儿AA的诊断价值。结果:各组改良Alvarado评分比较,对照组<单纯AA组<化脓性AA组<穿孔坏疽性AA组(均P<0.05); 观察组患儿的NLR、PCT和WBC水平均明显高于对照组(均P<0.05),单纯AA组、化脓性AA组和穿孔坏疽性AA组患儿NLR、PCT和WBC水平比较,单纯AA组<化脓性AA组<穿孔坏疽性AA组(均P<0.05)。ROC曲线分析结果显示,NLR、PCT、WBC及其联合检测诊断AA的AUC分别为0.808、0.763、0.729和0.844,均有统计学意义(均P<0.05),联合检测诊断AA的AUC值、灵敏度和特异度明显高于单一指标检测。结论:NLR、PCT和WBC水平升高与小儿AA的发生相关,对于小儿AA的诊断及病情评估有重要意义,三者联合检测可进一步提高临床诊断价值。
Abstract:
Objective:To explore the application value of neutrophil-to-lymphocyte ratio(NLR)combined with procalcitonin(PCT)and white blood cell(WBC)in the diagnosis and evaluation of acute appendicitis(AA)in children.Methods:A total of 157 children with AA were selected as the observation group.According to the results of surgical pathology,they were divided into simple AA group(35 cases),suppurative AA group(75 cases),and perforated or gangrenous AA group(47 cases).Meanwhile,102 children with non-AA abdominal pain treated in the same hospital during the same period were selected as the control group.The general clinical data,NLR,PCT and WBC were compared among the groups.The diagnostic value of NLR,PCT and WBC for AA in children was evaluated by using ROC curve.Results:The modified Alvarado scores increased in sequence from the control group,the simple AA group,the suppurative AA group to the perforated or gangrenous AA group(all P<0.05).The NLR,PCT and WBC in observation group were significantly higher than those in the control group(all P<0.05).Besides,the three indicators increased in sequence from the simple AA group,the suppurative AA group to the perforated or gangrenous AA group(all P<0.05).ROC curve analysis showed that the AUC values of NLR,PCT,WBC alone and in combination to detect AA were 0.808,0.763,0.729 and 0.844,respectively(all P<0.05).The AUC value,sensitivity and specificity of combined diagnosis were significantly higher than those of single index diagnosis.Conclusion:Elevated NLR,PCT and WBC are related to the occurrence of AA in children,which indicates that the three are of great significance for the diagnosis and evaluation of AA in children.In addition,combined detection of the three can improve the clinical diagnostic value.

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备注/Memo

备注/Memo:
基金项目:四川省卫生和计划生育委员会科研课题(150253)
更新日期/Last Update: 2023-08-07