[1]杨巍巍.中性粒细胞明胶酶相关脂质运载蛋白、核因子-κB、中性粒细胞/淋巴细胞比值、中性粒细胞/淋巴细胞和血小板比值、胱抑素C水平预测重症急性胰腺炎患者急性肾损伤的价值及临床检测意义[J].陕西医学杂志,2023,52(8):1055-1058,1084.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.026]
　YANG Weiwei.Value of levels of NGAL,NF-κB,NLR,N/LPR and Cys C in predicting SAP patients with acute kidney injury and its clinical monitoring significance[J].,2023,52(8):1055-1058,1084.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.026]
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中性粒细胞明胶酶相关脂质运载蛋白、核因子-κB、中性粒细胞/淋巴细胞比值、中性粒细胞/淋巴细胞和血小板比值、胱抑素C水平预测重症急性胰腺炎患者急性肾损伤的价值及临床检测意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年8期
页码:
1055-1058,1084
栏目:
临床研究
出版日期:
2023-08-05

文章信息/Info

Title:
Value of levels of NGAL,NF-κB,NLR,N/LPR and Cys C in predicting SAP patients with acute kidney injury and its clinical monitoring significance
作者:
杨巍巍
(大庆龙南医院检验科,黑龙江 大庆 163453)
Author(s):
YANG Weiwei
(Department of Laboratory Medicine,Daqing Longnan Hospital,Daqing 163453,China)
关键词:
重症急性胰腺炎;  急性肾损伤;  中性粒细胞明胶酶相关脂质运载蛋白;  核因子-κB;  中性粒细胞/淋巴细胞比值;  中性粒细胞/淋巴细胞和血小板比值
Keywords:
Severe acute pancreatitis;  Acute kidney injury;  Neutrophil gelatinase-associated lipocalin;  Nuclear factor-κB;  Neutrophil to lymphocyte ratio;  Neutrophil to lymphocyte and platelet count ratio
分类号:
R 576
DOI:
DOI:10.3969/j.issn.1000-7377.2023.08.026
文献标志码:
A
摘要:
目的:分析中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、核因子-κB(NF-κB)、中性粒细胞/淋巴细胞比值(NLR)、中性粒细胞/淋巴细胞和血小板比值(N/LPR)、胱抑素C(Cys C)水平预测重症急性胰腺炎(SAP)患者急性肾损伤的价值及临床检测意义。方法:选取SAP患者130例,根据急性肾损伤发生情况,将患者分为急性肾损伤组(56例)及非急性肾损伤组(74例)。回顾性收集研究对象的临床资料,比较两组临床资料与NGAL、NF-κB、NLR、N/LPR、Cys C水平,通过多因素Logistic回归分析法分析SAP患者急性肾损伤发生的危险因素,并构建回归模型,绘制受试者工作特征(ROC)曲线,分析NGAL、NF-κB、NLR、N/LPR、Cys C水平对急性肾损伤的预测价值。结果:多因素Logistic分析结果显示,休克、年龄升高、急性生理及慢性健康(APACHEⅡ)评分、血清NGAL、NF-κB、Cys C,全血NLR、N/LPR水平升高为SAP患者急性肾损伤发生的危险因素(均P<0.05)。以发生急性肾损伤组为阳性,以未发生急性肾损伤组为阴性,绘制ROC曲线,结果显示,NGAL、NF-κB、Cys C、NLR、N/LPR水平单独预测SAP患者伴急性肾损伤的曲线下面积(AUC)分别为0.796、0.755、0.886、0.836、0.726,以上指标联合预测急性肾损伤发生的AUC为0.939,明显高于各指标单独预测(P<0.05)。结论:休克、年龄升高、APACHEⅡ评分,血清NGAL、NF-κB、Cys C,全血NLR、N/LPR水平升高为SAP患者急性肾损伤发生的危险因素,且NGAL、NF-κB、NLR、N/LPR、Cys C水平预测SAP患者急性肾损伤的价值高。
Abstract:
Objective:To analyze levels of neutrophil gelatinase-associated lipocalin(NGAL),nuclear factor-κB(NF-κB),neutrophils to lymphocytes ratio(NLR),neutrophil to lymphocytes and platelets ratio(N/LPR)and cystatin C(Cys C)in predicting severe acute pancreatitis(SAP)patients with acute kidney injury and its clinical monitoring significance.Methods:A total of 130 patients with SAP were divided into acute renal injury group(56 cases)and non-acute renal injury group(74 cases)according to the occurrence of acute kidney injury,and clinical data of research subjects were retrospective collected.The clinical data and levels of NGAL,NF-κB,NLR,N/LPR,and Cys C were compared between the two groups,and the risk factors for acute kidney injury in SAP patients were analyzed by multivariate Logistic regression analysis,and the predictive value of NGAL,NF-κB,NLR,N/LPR for acute kidney injury were analyzed by ROC curve.Results:Multivariate Logistic analysis showed that shock,age,acute physiology chronichealth evaluation Ⅱ(APACHEⅡ),serum levels of NGAL,NF-κB,Cys C,and whole blood levels of NLR and N/LPR increased were the risk factors for acute kidney injury in SAP patients(all P<0.05).Taking the acute kidney injury group as positive and the non-acute kidney injury group as negative,the ROC curve was drawn,and the results showed that,the AUC of NGAL,NF-κB,Cys C,NLR,and N/LPR levels in predicting acute kidney injury in SAP patients were 0.796,0.755,0.886,0.836,0.726,and the AUC of the combined prediction of the above indicators for acute kidney injury was 0.939,which was significantly higher than that of each indicator alone(all P<0.05).Conclusion:Shock,increasing age,score of APACHE Ⅱ,serum levels of NGAL,NF-κB,Cys C,and whole blood levels of NLR,N/LPR were the risk factors for acute kidney injury in SAP patients,and levels of NGAL,NF-κB,NLR,N/LPR,Cys C had high predictive value in SAP patients with acute kidney injury.

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备注/Memo

备注/Memo:
基金项目:国家卫生健康委员会“十四五”规划全国重点课题(YYWS4149)
更新日期/Last Update: 2023-08-07