[1]蔺 洁,雷 烨,李晓苗,等.小泛素化修饰调控糖尿病心肌病发生与发展[J].陕西医学杂志,2023,52(7):929-933.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.035]
　LIN Jie,LEI Ye,LI Xiaomiao,et al.SUMO modification regulates occurrence and development of diabetic cardiomyopathy[J].,2023,52(7):929-933.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.035]
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小泛素化修饰调控糖尿病心肌病发生与发展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年7期
页码:
929-933
栏目:
综 述
出版日期:
2023-07-05

文章信息/Info

Title:
SUMO modification regulates occurrence and development of diabetic cardiomyopathy
作者:
蔺 洁1; 2; 雷 烨1; 李晓苗2; 周 洁2
(1.陕西中医药大学,陕西 咸阳 712046; 2.空军军医大学西京医院内分泌科, 陕西 西安 710032)
Author(s):
LIN Jie; LEI Ye; LI Xiaomiao; ZHOU Jie
(Shaanxi University of Chinese Medicine,Xianyang 712046,China)
关键词:
糖尿病心肌病;  翻译后修饰;  小泛素化修饰;  氧化应激;  线粒体;  炎症
Keywords:
Diabetic cardiomyopathy;  Post-translational modification;  SUMO;  Oxidative stress;  Mitochondria;  Inflammation
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7377.2023.07.035
文献标志码:
A
摘要:
糖尿病心肌病(DCM)是糖尿病最常见的大血管并发症之一,主要特点是心肌舒张和收缩功能障碍,末期出现心力衰竭,严重影响患者的生活质量。DCM的病理生理机制复杂,心肌葡萄糖和脂质代谢紊乱增强氧化应激,激活各种炎症途径,导致心肌重塑,严重影响患者心功能。近年来,随着研究者对表观遗传的深入认识,翻译后修饰(PTM)成为研究热点。小泛素化修饰(SUMO)作为PTM修饰的一种,其在DCM发生发展中的地位和作用引起了研究者的重点关注。现就SUMO化修饰与DCM最新研究进展进行综述。
Abstract:
Diabetic cardiomyopathy(DCM)is one of the most common macrovascular complications of diabetes mellitus.It is characterized by dysdiastolic and systolic dysfunction of the myocardium,leading to end-stage heart failure,which seriously affects the quality of life of patients.The pathophysiological mechanism of DCM is complex.The disorder of myocardial glucose and lipid metabolism enhances oxidative stress,activates various inflammatory pathways,so as to induce myocardial remodeling,which seriously affects the cardiac function of patients.In recent years,with the in-depth understanding of epigenetic inheritance,post-translational modification(PTM )has become a research hotspot.As a kind of PTM,SUMO modification has attracted the attention of researchers for its status and role in the occurrence and development of DCM.This article reviews the recent research progress of SUMO modification and DCM.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82070839)
更新日期/Last Update: 2023-07-05