[1]吕瑜玫,陈 丹,朱 桥,等.宫颈癌患者血清微小核糖核酸-381、微小核糖核酸-145水平变化及与临床病理参数相关性分析[J].陕西医学杂志,2023,52(7):925-928.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.034]
　LYU Yumei,CHEN Dan,ZHU Qiao,et al.Changes of serum microRNA-381 and microRNA-145 levels and their correlation with clinicopathological parameters in patients with cervical cancer[J].,2023,52(7):925-928.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.034]
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宫颈癌患者血清微小核糖核酸-381、微小核糖核酸-145水平变化及与临床病理参数相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年7期
页码:
925-928
栏目:
临床病理
出版日期:
2023-07-05

文章信息/Info

Title:
Changes of serum microRNA-381 and microRNA-145 levels and their correlation with clinicopathological parameters in patients with cervical cancer
作者:
吕瑜玫; 陈 丹; 朱 桥; 王 丹
(解放军西部战区总医院妇产科,四川 成都 610083)
Author(s):
LYU Yumei; CHEN Dan; ZHU Qiao; WANG Dan
(Department of Obstetrics and Gynecology,General Hospital of PLA Western Theater Command,Chengdu 610083,China)
关键词:
宫颈癌;  微小核糖核酸-381;  微小核糖核酸-145;  定量聚合酶链反应法;  临床病理参数
Keywords:
Cervical cancer;  miRNA-381;  miRNA-145;  QRT-PCR;  Clinicopathologic parameter
分类号:
R 737.33
DOI:
DOI:10.3969/j.issn.1000-7377.2023.07.034
文献标志码:
A
摘要:
目的:探讨宫颈癌(CC)患者血清微小核糖核酸-381(miRNA-381)、微小核糖核酸-145(miRNA-145)水平的变化及与临床病理参数的关系。方法:选取CC患者80例作为观察组,并于同期健康女性体检者选取68例作为对照组。采用定量聚合酶链反应法(QRT-PCR)检测两组血清miRNA-381、miRNA-145表达水平,同时收集其临床病理资料,探究血清表达水平与临床病理参数的关系。结果:观察组血清miRNA-381、miRNA-145水平低于对照组(均P<0.05); CC患者血清miRNA-381、miRNA-145表达水平与患者年龄、乳头瘤病毒感染、肿瘤直径、病理分期等因素无关(均P>0.05); 与病理类型、组织分化程度、浸润深度、脉管浸润、淋巴结转移有关(均P<0.05)。结论:CC患者中血清miRNA-381、miRNA-145呈低表达,其表达水平与病理类型、组织分化程度、浸润深度、脉管浸润、淋巴结转移有关。
Abstract:
Objective:To explore the changes of serum microRNA-381(miRNA-381)and miRNA-145,and their relationship with clinicopathologic parameters in patients with cervical cancer(CC).Methods:A total of 80 patients with CC and 68 healthy females undergoing physical examination were enrolled as observation group and control group,respectively.The expression levels of serum miRNA-381 and miRNA-145 in the two groups were detected by quantitative reverse transcription polymerase chain reaction(QRT-PCR).The clinicopathologic data were collected to explore the relationship between serum indexes and clinicopathologic parameters.Methods:The levels of serum miRNA-381 and miRNA-145 in observation group were lower than those in control group(all P<0.05).The expression levels of serum miRNA-381 and miRNA-145 were not correlated with age,papillomavirus infection,tumor diameter or pathological staging in CC patients(all P>0.05),but were correlated with pathological types,tissue differentiation degree,invasion depth,vascular invasion and lymph node metastasis(all P<0.05).Results:The expressions of serum miRNA-381 and miRNA-145 are down-regulated in CC patients,which are related to pathological types,tissue differentiation degree,invasion depth,vascular invasion and lymph node metastasis.

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备注/Memo

备注/Memo:
基金项目:四川省科技计划项目(21YYJC3617)
更新日期/Last Update: 2023-07-05