[1]许 严,麦 刚.ω-3多不饱和脂肪酸强化的肠外营养对胰腺癌患者术后炎性介质及免疫功能的影响[J].陕西医学杂志,2023,52(7):862-866，888.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.020]
　XU Yan,MAI Gang.Effects of ω-3 polyunsaturated fatty acid-enhanced parenteral nutrition on postoperative inflammatory mediators and immune function in patients with pancreatic cancer[J].,2023,52(7):862-866，888.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.020]
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ω-3多不饱和脂肪酸强化的肠外营养对胰腺癌患者术后炎性介质及免疫功能的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年7期
页码:
862-866，888
栏目:
临床研究
出版日期:
2023-07-05

文章信息/Info

Title:
Effects of ω-3 polyunsaturated fatty acid-enhanced parenteral nutrition on postoperative inflammatory mediators and immune function in patients with pancreatic cancer
作者:
许 严1; 麦 刚1; 2
(1.西南医科大学,四川 泸州 646000; 2.德阳市人民医院普外科,四川 德阳 618000)
Author(s):
XU Yan; MAI Gang
(Southwest Medical University,Luzhou 646000,China)
关键词:
ω-3多不饱和脂肪酸;  肠外营养;  胰腺癌;  炎性介质;  免疫功能;  并发症
Keywords:
ω-3 Polyunsaturated fatty acid;  Parenteral nutrition;  Pancreatic cancer;  Inflammatory mediators;  Immune function;  Complications
分类号:
R 735.9
DOI:
DOI:10.3969/j.issn.1000-7377.2023.07.020
文献标志码:
A
摘要:
目的:探究经ω-3多不饱和脂肪酸强化的肠外营养对胰腺癌(PCA)根治术患者术后炎性介质及免疫功能的影响。方法:将接受胰十二指肠切除术的80例PCA患者随机分为常规组(n=40)和ω-3组(n=40),常规组术后给予常规肠外营养治疗,ω-3组给予ω-3多不饱和脂肪酸强化的肠外营养治疗,均治疗14 d。比较两组术前、术后1 d、术后7 d、术后14 d血常规指标[白细胞(WBC)、淋巴细胞百分率(LYMPH%)、中性粒细胞在白细胞中所占百分比(NEUT%)、红细胞(RBC)]、营养指标[总蛋白(TP)、白蛋白(ALB)、前白蛋白(PALB)]、炎性介质[白细胞介素-6(IL-6)、白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)]和免疫指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、成熟T淋巴细胞(CD3+)、诱导性T细胞(CD4+)]变化,并对比两组并发症情况、住院时间及住院费用。结果:术后,两组患者WBC、NEUT、RBC均呈先增加后下降趋势(均P<0.05),且ω-3组与常规组比较无统计学差异(P>0.05); 两组患者LYMPH呈先降低后增加趋势(P<0.05),ω-3组与常规组比较无统计学差异(P>0.05)。术后,两组患者TP、ALB、PALB、IgA、IgG、CD3+、CD4+均呈先降低后增加趋势(均P<0.05),且ω-3组大于常规组(P<0.05); 两组患者IL-6、IL-1、TNF-α均呈先降低后增加趋势(均P<0.05),且ω-3组小于常规组(P<0.05); 两组并发症发生、总住院天数和术后住院天数比较无统计学差异(均P>0.05); ω-3组总住院费用显著高于常规组(P<0.05)。结论:经ω-3多不饱和脂肪酸强化的肠外营养对胰腺癌患者术后效果理想,可有效改善营养水平,调节炎性介质和免疫功能,但花费较高。
Abstract:
Objective:To investigate the effects of ω-3(omega-3)polyunsaturated fatty acid-enhanced parenteral nutrition on postoperative inflammatory mediators and immune function in patients with radical resection of pancreatic cancer(PCA).Methods:A total of 80 patients with PCA who received pancreaticoduodenectomy were selected and randomly divided into conventional group(40 cases)and ω-3 group(40 cases).The conventional group was given conventional parenteral nutrition therapy after surgery,and the ω-3 group was given ω-3 polyunsaturated fatty acid-enhanced parenteral nutrition therapy,and both groups were treated for 14 days.Blood routine parameters [white blood cell(WBC),lymphocyte percentage(LYMPH%),neutrophil percentage in white blood cells(NEUT%),red blood cell(RBC)],nutritional parameters [total protein(TP),albumin(ALB),prealbumin(PALB)],inflammatory mediators [interleukin 6(IL-6),IL-1,tumor necrosis factor-α(TNF-α)] and immune indicators [immunoglobulin A(IgA),immunoglobulin G(IgG),mature T lymphocyte(CD3+),inducible T cell(CD4+)] were compared between the two groups before surgery and at 1,7,14 days after surgery.The complications,hospital stay and hospitalization cost were compared between the two groups.Results:After surgery,the WBC,NEUT and RBC were first increased and then decreased in both groups(all P<0.05),and there were no significant differences between ω-3 group and conventional group(all P>0.05).LYMPH in the two groups was decreased first and then increased(all P<0.05),but there was no significant difference between ω-3 group and conventional group(all P>0.05).After surgery,the TP,ALB,PALB,IgA,IgG,CD3+ and CD4+ in the two groups were first reduced and then risen(all P<0.05),and their levels in ω-3 group were higher than those in conventional group(all P<0.05).IL-6,IL-1 and TNF-α in both groups were first declined and then elevated(all P<0.05),and their levels in ω-3 group were lower than those in conventional group(all P<0.05).There were no significant differences in the occurrence of complications,total hospital stay and postoperative hospital stay between the two groups(all P>0.05).The total hospitalization cost in ω-3 group was significantly higher than that in conventional group(P<0.05).Conclusion:ω-3 polyunsaturated fatty acid-enhanced parenteral nutrition has ideal postoperative effect on patients with pancreatic cancer,and it can effectively improve the nutrition level,regulate inflammatory mediators and immune function,but its cost is high.

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备注/Memo

备注/Memo:
基金项目:四川省德阳市科技计划重点研发项目(2021SZZ053)
更新日期/Last Update: 2023-07-05