[1]邱 瑛,杨玉洁,袁怀红.维持性血液透析患者皮肤瘙痒临床研究进展[J].陕西医学杂志,2023,52(6):775-封3.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.031]
 QIU Ying,YANG Yujie,YUAN Huaihong.Clinical research progress of pruritus in patients undergoing maintenance hemodialysis[J].,2023,52(6):775-封3.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.031]
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维持性血液透析患者皮肤瘙痒临床研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年6期
页码:
775-封3
栏目:
综 述
出版日期:
2023-06-05

文章信息/Info

Title:
Clinical research progress of pruritus in patients undergoing maintenance hemodialysis
作者:
邱 瑛杨玉洁袁怀红
(四川大学华西医院肾脏内科血液透析中心,四川 成都 610041)
Author(s):
QIU YingYANG YujieYUAN Huaihong
(Hemodialysis Center,Department of Nephrology,West China Hospital of Sichuan University,Chengdu 610041,China)
关键词:
维持性血液透析 皮肤瘙痒 发病机制 毒素蓄积 微炎症状态 高通量血液透析
Keywords:
Maintenance hemodialysis Pruritus Pathogenesis Toxin accumulation Micro-inflammatory state High-flux hemodialysis
分类号:
R 275.9
DOI:
DOI:10.3969/j.issn.1000-7377.2023.06.031
文献标志码:
A
摘要:
皮肤瘙痒是维持性血液透析(MHD)患者的常见合并症,其发生与发展涉及一系列复杂的生理病理变化,发病机制尚未阐明,目前发现与皮肤含水量、尿毒症毒素蓄积、离子代谢紊乱、内分泌失调、微炎症状态、免疫功能紊乱、组胺水平异常、周围神经病变等多因素有关。基于多种发病机制也衍生出多样化的治疗方案,如血液透析联合血液灌流、高通量血液透析、抗过敏治疗等。现对目前MHD患者皮肤瘙痒发病机制和治疗方案的研究进展进行阐述。
Abstract:
Pruritus is a common complication in patients undergoing maintenance hemodialysis(MHD).Its occurrence and development involve a series of complex physiological and pathological changes.The pathogenesis of pruritus has not been elucidated.At present,it is found to be related to skin water content,uremic toxin accumulation,ion metabolism disorder,endocrine disorder,micro-inflammatory state,immune dysfunction,abnormal histamine level,peripheral neuropathy and other factors.A variety of treatments have also been derived based on a variety of pathogenesis,such as hemodialysis combined with hemoperfusion,high-flux hemodialysis,anti-allergic therapy,etc.This article reviews the current research progress on the pathogenesis and treatment of pruritus in MHD patients.

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备注/Memo

备注/Memo:
基金项目:四川省卫生和计划生育委员会科研课题(18PJ363)
更新日期/Last Update: 2023-06-05