[1]戴松松,刘 昉.甲状腺素信号通路调控自噬机制研究进展[J].陕西医学杂志,2023,52(6):764-767.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.028]
 DAI Songsong,LIU Fang.Research progress on mechanism of thyroxine signaling pathway regulating autophagy[J].,2023,52(6):764-767.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.028]
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甲状腺素信号通路调控自噬机制研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年6期
页码:
764-767
栏目:
综 述
出版日期:
2023-06-05

文章信息/Info

Title:
Research progress on mechanism of thyroxine signaling pathway regulating autophagy
作者:
戴松松刘 昉
(桂林医学院基础医学院解剖学教研室,广西 桂林 541199)
Author(s):
DAI SongsongLIU Fang
(Department of Anatomy,Basic Medicine College,Guilin Medical University,Guilin 541199,China)
关键词:
甲状腺素 自噬 甲状腺素核受体 甲状腺激素反应元件 线粒体 溶酶体
Keywords:
Thyroid hormone Autophagy Thyroid hormone nuclear receptor Thyroid hormone response element Mitochondrion Lysosome
分类号:
R 34
DOI:
DOI:10.3969/j.issn.1000-7377.2023.06.028
文献标志码:
A
摘要:
甲状腺素是机体发育和维持正常生理活动不可缺少的激素之一,其通过与甲状腺素核受体(TRs)等相结合发挥作用,参与了机体大部分的生命活动。自噬作为一种在进化上相对保守的机制,广泛存在于不同类型的细胞中。在营养物质缺乏及面临外界压力的情况下,自噬发挥着清除受损细胞器并提供代谢底物的作用。虽然有大量文献分别对甲状腺素信号通路和自噬机制进行了深入的研究,但两者的关系尚不明确。现对近年来在不同系统性疾病中甲状腺素信号通路对自噬影响的研究进行总结,以阐明两者间复杂的作用关系。
Abstract:
Thyroid hormone is one of the indispensable hormones for body development and maintenance of normal physiological activities.It plays a role by combining with thyroid hormone nuclear receptors(TRs)and participates in most of the life activities of the body.As an evolutionarily relatively conserved mechanism,autophagy is widely present in different cell types.In the absence of nutrients and in the face of external stress,autophagy plays a role in removing damaged organelles and providing metabolic substrates.Although there are a large number of in-depth studies on thyroid hormone signaling pathway and autophagy mechanism,the relationship between them is still unclear.This article reviews recent studies on the effect of thyroxine signaling pathway on autophagy in different systemic diseases to clarify the complex relationship between them.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82160063)
更新日期/Last Update: 2023-06-05