[1]董 勇,程 序,梁 晗,等.肝癌组织角蛋白23表达与患者临床病理特征及预后关系研究[J].陕西医学杂志,2023,52(6):756-759.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.026]
 DONG Yong,CHENG Xu,LIANG Han,et al.Relationship between keratin 23 expression and clinicopathological features and prognosis of patients with hepatocellular carcinoma[J].,2023,52(6):756-759.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.026]
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肝癌组织角蛋白23表达与患者临床病理特征及预后关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年6期
页码:
756-759
栏目:
临床病理
出版日期:
2023-06-05

文章信息/Info

Title:
Relationship between keratin 23 expression and clinicopathological features and prognosis of patients with hepatocellular carcinoma
作者:
董 勇程 序梁 晗华 静谭莉霞王航宇闫春晓魏书堂
(河南大学第一附属医院消化内科,河南 开封 475100)
Author(s):
DONG YongCHENG XuLIANG HanHUA JingTAN LixiaWANG HangyuYAN ChunxiaoWEI Shutang
(Department of Gastroenterology,the First Affiliated Hospital of Henan University,Kaifeng 475100,China)
关键词:
肝癌 角蛋白23 临床病理特征 预后 危险因素
Keywords:
Hepatocellular carcinoma Keratin 23 Clinicopathological features Prognosis Risk factors
分类号:
R 735.7
DOI:
DOI:10.3969/j.issn.1000-7377.2023.06.026
文献标志码:
A
摘要:
目的:分析肝癌组织中角蛋白23(KRT23)表达与患者临床病理特征及预后的关系。方法:收集接受手术治疗的肝癌患者86例。采用免疫组织化学和蛋白免疫印迹检测肝癌组织及癌旁正常组织(距离癌组织5 cm以上)KRT23表达水平并进行比较。分析KRT23表达与患者临床病理特征的关系。采用Kaplan-Meier法分析肝癌KRT23表达与肝癌患者预后的关系。采用Cox回归分析影响肝癌患者预后的因素。结果:蛋白免疫印迹结果显示,癌旁正常组织KRT23相对表达水平低于肝癌组织(P<0.05)。免疫组织化学检测结果显示,肝癌组织KRT23阳性表达率高于癌旁正常组织(P<0.05)。TNM分期Ⅲ期患者肝癌组织KRT23阳性表达水平显著高于Ⅰ-Ⅱ期肝癌患者(P<0.05)。多因素Cox回归分析表明,TNM分期Ⅲ期、KRT23阳性是肝癌患者预后不良的独立危险因素(均P<0.05)。KRT23阴性患者3年累积生存率高于KRT23阳性患者(P<0.05)。结论:肝癌组织KRT23呈高表达,与肝癌患者预后不良密切相关。
Abstract:
Objective:To analyze the relationship between keratin 23(KRT23)expression and clinicopathologic features and prognosis of patients with hepatocellular carcinoma.Methods:A total of 86 patients with hepatocellular carcinoma who received surgical treatment were collected.Immunohistochemistry and Western blot were used to detect the expression of KRT23 in cancer tissue and adjacent normal tissue(more than 5 cm from the cancer tissue).The relationship between KRT23 expression and clinicopathologic features of patients was analyzed.Kaplan-Meier method was used to analyze the relationship between KRT23 expression and prognosis of hepatocellular carcinoma patients.The factors influencing prognosis of patients with hepatocellular carcinoma were analyzed by Cox regression.Results:Western blot showed that the relative expression level of KRT23 in adjacent normal tissue was lower than that in cancer tissue(P<0.05).Immunohistochemical test results showed that the positive expression rate of KRT23 in cancer tissue was higher than that in adjacent normal tissue(P<0.05).The positive expression level of KRT23 in cancer tissue of patients with TNM stage Ⅲ was significantly higher than that of patients with TNM stage Ⅰ-Ⅱ(P<0.05).Multivariate Cox regression analysis showed that TNM stage Ⅲ and KRT23 positive were independent risk factors for poor prognosis in patients with hepatocellular carcinoma(all P<0.05).The 3-year cumulative survival rate of KRT23-negative patients was higher than that of KRT23-positive patients(P<0.05).Conclusion:High expression of KRT23 in liver cancer tissues is closely related to poor prognosis of patients with hepatocellular carcinoma.

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备注/Memo

备注/Memo:
基金项目:河南省医学科技攻关计划联合共建项目(LHGJ20200539)
更新日期/Last Update: 2023-06-05