[1]李 超,熊 兰,卢元明.银杏叶提取物联合茴拉西坦治疗血管性痴呆疗效观察[J].陕西医学杂志,2023,52(6):737-740.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.022]
　LI Chao,XIONG Lan,LU Yuanming.Efficacy of ginkgo biloba extract combined with aniracetam in treatment of vascular dementia[J].,2023,52(6):737-740.[doi:DOI:10.3969/j.issn.1000-7377.2023.06.022]
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银杏叶提取物联合茴拉西坦治疗血管性痴呆疗效观察
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年6期
页码:
737-740
栏目:
药物与临床
出版日期:
2023-06-05

文章信息/Info

Title:
Efficacy of ginkgo biloba extract combined with aniracetam in treatment of vascular dementia
作者:
李 超; 熊 兰; 卢元明
(广元市第一人民医院神经内科,四川 广元 628017)
Author(s):
LI Chao; XIONG Lan; LU Yuanming
(Department of Neurology,the First People's Hospital of Guangyuan,Guangyuan 628017,China)
关键词:
血管性痴呆;  银杏叶提取物;  茴拉西坦;  认知功能;  行为能力;  血流动力学
Keywords:
Vascular dementia;  Ginkgo biloba extract;  Aniracetam;  Cognitive function;  Behavioral ability;  Hemodynamics
分类号:
R749.13
DOI:
DOI:10.3969/j.issn.1000-7377.2023.06.022
文献标志码:
A
摘要:
目的:探讨银杏叶提取物联合茴拉西坦治疗血管性痴呆(VD)的疗效。方法:选择VD患者96例,随机分为观察组(给予茴拉西坦+银杏叶提取物)与对照组(给予茴拉西坦),各48例,疗程为12周。比较两组临床疗效、认知功能、行为能力、血流动力学、血清学指标变化。结果:观察组总有效率高于对照组(P<0.05)。治疗后,两组简易精神状态量表(MMSE)评分、阿尔茨海默病评定量表认知部分(ADAS-Cog)评分、Blessed行为量表(BBS)评分和日常生活活动能力量表(BI)评分优于治疗前,且观察组优于对照组(均P<0.05)。治疗后,两组大脑中动脉(MCA)平均血流速度以及血清内皮素-1(ET-1)、丙二醛(MDA)、胰岛素样生长因子-1(IGF-1)水平优于治疗前,且观察组优于对照组(均P<0.05)。结论:银杏叶提取物联合茴拉西坦治疗VD疗效显著,可改善患者认知功能和行为能力,降低血清ET-1和MDA水平,提高IGF-1水平。
Abstract:
Objective:To explore the effect of ginkgo biloba extract combined with aniracetam on vascular dementia(VD).Methods:Ninety-six patients with VD were randomly divided into observation group(receiving aniracetam + ginkgo biloba extract)and control group(receiving aniracetam),48 cases in each group,and treatment course was 12 weeks.The clinical efficacy,cognitive function,behavioral ability,hemodynamics and serological indexes were compared between the two groups.Results:The observation group effective rate higher control group(P<0.05).After treatment,the scores of MMSE,ADAS-Cog,BBS and BI in two groups were better than those before treatment,and observation group was better than control group(all P<0.05).After treatment,the mean blood flow velocity of MCA,serum levels of ET-1,MDA and IGF-1 in two groups were better than those before treatment,and observation group was better than control group(all P<0.05).Conclusion:Ginkgo biloba extract combined with aniracetam is effective in the treatment of VD,which can improve cognitive function and behavioral ability,reduce serum ET-1 and MDA levels,and increase IGF-1 level.

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备注/Memo

备注/Memo:
基金项目:四川省科技计划项目(2019YJ0702)
更新日期/Last Update: 2023-06-05