[1]侯 广,邹循亮.Wnt/β-catenin信号通路在腹膜透析相关性腹膜纤维化中的作用研究进展[J].陕西医学杂志,2023,52(5):630-封3.[doi:DOI:10.3969/j.issn.1000-7377.2023.05.031]
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Wnt/β-catenin信号通路在腹膜透析相关性腹膜纤维化中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年5期
页码:
630-封3
栏目:
综 述
出版日期:
2023-05-05

文章信息/Info

作者:
侯 广邹循亮
[遵义医科大学第五附属(珠海)医院肾内科,广东 珠海 519000]
关键词:
腹膜透析 腹膜纤维化 Wnt/β-catenin信号通路 TGF-β/Smads信号通路 间皮细胞间充质转分化 巨噬细胞
分类号:
R 459.5
DOI:
DOI:10.3969/j.issn.1000-7377.2023.05.031
文献标志码:
A
摘要:
腹膜透析是慢性肾衰竭患者重要的替代治疗方法之一。腹膜纤维化是长期腹膜透析失败的主要原因,其发生机制仍不完全清楚,可能与间皮细胞间充质转分化、血管新生及慢性炎性反应等机制有关。目前研究发现Wnt/β-catenin信号通路参与调控腹膜透析相关性腹膜纤维化的发生发展。深入探讨Wnt/β-catenin通路在腹膜纤维化的作用机制有助于发现新的治疗靶点,为阻抑腹膜透析过程中腹膜纤维化的发生、发展提出新的治疗策略。

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相似文献/References:

[1]冯婷,梁衍,王晓明,等.终末期多囊肾患者行腹膜透析的疗效及安全性分析[J].陕西医学杂志,2016,(10):1361.
[2]袁江红.腹膜透析与血液透析治疗终末期糖尿病肾病患者疗效比较[J].陕西医学杂志,2016,(10):1365.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81860143); 广东省医学科学技术研究基金资助项目(A2019436); 贵州省卫生和计划生育委员会科学技术基金资助项目(GZWJKJ2018-1-014)
更新日期/Last Update: 2023-05-05