[1]徐梓凡,郑昊涵,谢田华,等.环状RNA功能及与眼科相关疾病关系研究进展[J].陕西医学杂志,2023,52(5):626-629,封3.[doi:DOI:10.3969/j.issn.1000-7377.2023.05.030]
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环状RNA功能及与眼科相关疾病关系研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年5期
页码:
626-629,封3
栏目:
综 述
出版日期:
2023-05-05

文章信息/Info

作者:
徐梓凡郑昊涵谢田华王晓露姚 勇
(南京医科大学附属无锡人民医院眼科,江苏 无锡 214023)
关键词:
环状RNA 糖尿病视网膜病变 年龄相关性黄斑变性 角膜疾病 青光眼 白内障
分类号:
R 77
DOI:
DOI:10.3969/j.issn.1000-7377.2023.05.030
文献标志码:
A
摘要:
环状RNA(circRNA)是一类单链封闭环状的内源性非编码RNA,其不具有5'端帽和3'poly-A尾结构,在许多生理和病理过程中起着重要的作用。circRNA具有稳定性、广泛性、保守性及组织特异性等特点,已成为多种疾病诊断和治疗的重要靶点。目前,已经发现circRNA在多种眼病的患者体内异常表达,如糖尿病视网膜病变、年龄相关性黄斑变性、青光眼、角膜新生血管性眼病、白内障等。现阐述circRNA的一般特征和功能,以及它们在眼科疾病中的作用,并探讨其在眼病治疗和诊断中的潜在应用价值。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81770941,81800845)
更新日期/Last Update: 2023-05-05