[1]惠 盼,谯钰琪,董济民,等.葡萄糖调节蛋白78表达与非小细胞肺癌临床病理特征相关性Meta分析[J].陕西医学杂志,2023,52(4):481-486,491.[doi:DOI:10.3969/j.issn.1000-7377.2023.04.027]
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葡萄糖调节蛋白78表达与非小细胞肺癌临床病理特征相关性Meta分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年4期
页码:
481-486,491
栏目:
Meta分析
出版日期:
2023-04-05

文章信息/Info

作者:
惠 盼12谯钰琪12董济民3南岩东1
(1.空军军医大学唐都医院呼吸与危重症医学科,陕西 西安 710038; 2.延安大学医学院,陕西 延安 716000; 3.西安市中心医院肿瘤科,陕西 西安 710038)
关键词:
葡萄糖调节蛋白78 非小细胞肺癌 淋巴结转移 分化程度 临床分期 病理类型
分类号:
R 734.2
DOI:
DOI:10.3969/j.issn.1000-7377.2023.04.027
文献标志码:
A
摘要:
目的:应用Meta分析探讨葡萄糖调节蛋白78(GRP78)的表达与非小细胞肺癌(NSCLC)临床病理学特征的相关性。方法:检索考克兰图书馆(Cochrane Library)、中国知网(CNKI)、中国生物医学文献服务系统(Sino Med)、维普(VIP)、万方(Wanfang Data)、Pub Med数据库、Embase数据库中关于GRP78的表达与非小细胞肺癌临床病理学特征的相关性文献,根据纳入及排除标准筛选文献。采用 Rev Man5.4和Stata SE12.0软件分析纳入文献资料中GRP78蛋白的表达与非小细胞肺癌的年龄、性别、分化程度、淋巴结转移、临床分期及病理类型的相关性。结果:纳入的11篇文献中,将共计1177例非小细胞肺癌患者样本进行分析。结果显示:GRP78在非小细胞肺癌组织中的表达明显高于癌旁正常组织[OR=8.49,95%CI(3.50,20.59),Z=4.73,P<0.00001]; GRP78 的高表达与非小细胞肺癌组织低分化[OR=2.75,95%CI(1.69,2.37),Z=2.37,P= 0.02]、Ⅲ -Ⅳ期(TNM 分期)[OR=0.37,95%CI(0.25,0.55),P<0.00001]、淋巴结转移[OR=0.65,95%CI(0.45,0.94),Z=2.30,P= 0.02]有统计学意义; GRP78的表达与非小细胞肺癌的病理类型[OR=1.19,95%CI(0.86,1.65),Z=1.08,P=0.28]无统计学意义; GRP78的表达在不同性别[OR=1.02,95%CI(0.77,1.35),Z=0.11,P=0.91]和不同年龄段[OR=1.03,95%CI(0.57,1.88),Z=0.1,P=0.92]的非小细胞肺癌患者中的表达无统计学差异。结论:GRP78的高表达与非小细胞肺癌患者的临床病理特征密切相关,并且参与非小细胞肺癌的发生和发展。

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备注/Memo

备注/Memo:
基金项目:陕西省社会发展科技攻关项目(2016SF-318); 空军军医大学唐都医院创新发展基金资助项目(2017LCYJ016)
更新日期/Last Update: 2023-04-06