[1]刘 剑,陈 亮.Tau蛋白、胶质纤维酸性蛋白在创伤性颅脑损伤程度不同患者中的表达及其与患者认知障碍相关性研究[J].陕西医学杂志,2023,52(4):452-455.[doi:DOI:10.3969/j.issn.1000-7377.2023.04.020]
　LIU Jian,CHEN Liang.Expression of Tau and glial fibrillary acidic protein in patients with different degrees of traumatic brain injury and their correlation with cognitive impairment[J].,2023,52(4):452-455.[doi:DOI:10.3969/j.issn.1000-7377.2023.04.020]
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Tau蛋白、胶质纤维酸性蛋白在创伤性颅脑损伤程度不同患者中的表达及其与患者认知障碍相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年4期
页码:
452-455
栏目:
临床研究
出版日期:
2023-04-05

文章信息/Info

Title:
Expression of Tau and glial fibrillary acidic protein in patients with different degrees of traumatic brain injury and their correlation with cognitive impairment
作者:
刘 剑; 陈 亮
(商洛市中心医院急诊医学科,陕西 商洛 726000)
Author(s):
LIU Jian; CHEN Liang
(Department of Emergency Medicine,Shangluo Central Hospital,Shangluo 726000,China)
关键词:
Tau蛋白;  胶质纤维酸性蛋白;  创伤性颅脑损伤;  认知障碍;  洛文斯顿认知功能成套评估;  相关性
Keywords:
Tau protein;  Glial fibrillary acidic protein;  Traumatic brain injury;  Cognitive impairment;  LOTCA;  Correlation
分类号:
R 641
DOI:
DOI:10.3969/j.issn.1000-7377.2023.04.020
文献标志码:
A
摘要:
目的:分析Tau蛋白、胶质纤维酸性蛋白(GFAP)在创伤性颅脑损伤程度不同患者中的表达情况,并分析其与患者认知障碍的关联性,为临床诊疗提供理论依据。方法:研究对象选取就诊治疗的创伤性颅脑损伤(TBI)患者,其中包括轻度组、中度组、重度组患者各58例。比较各组患者不同时期Tau、GFAP水平,并采用洛文斯顿认知功能成套评估工具(LOTCA)对不同时期各组患者认知功能进行评估; 同时对Tau、GFAP 水平与各组患者LOTCA评分的相关性进行分析。结果:与轻度组患者相比,中度组及重度组患者不同时期Tau、GFAP水平显著升高(均P<0.05),LOTCA评分显著降低(P<0.05),且各组间比较存在统计学差异(均P<0.05)。与入院12 h相比,同组患者入院24 h及入院3 d Tau水平、GFAP水平及LOTCA评分显著升高(均P<0.05),且各组内存在统计学差异(均P<0.05)。对于轻度组、中度组及重度组TBI患者而言,Tau、GFAP表达水平与患者LOTCA评分呈负相关,差异有统计学意义(均P<0.05)。结论:Tau、GFAP 水平随着TBI患者病情严重程度的增加呈升高趋势,同时Tau、GFAP表达水平均与轻型、中型及重型TBI患者LOTCA评分呈显著负相关,提示Tau、GFAP水平对TBI患者病情评估具有积极意义,对患者Tau、GFAP水平进行动态监测,有助于及时对临床治疗进行调整,临床应用价值较高。
Abstract:
Objective:To analyze the expression of Tau protein and glial fibrillary acidic protein(GFAP)in patients with different degrees of traumatic brain injury(TBI),and analyze their correlation with cognitive impairment of patients,so as to provide theoretical basis for clinical diagnosis and treatment.Methods:Patients with TBI were selected,including 58 cases in mild group,58 cases in moderate group and 58 cases in severe group.The levels of Tau and GFAP in different periods were compared among the groups,and the Loewenstein Occupational Therapy Cognitive Assessment(LOTCA)was used to evaluate the cognitive function of the patients in different periods.At the same time,the correlation between Tau,GFAP levels and LOTCA scores in each group was analyzed.Results:Compared with the mild group,the levels of Tau and GFAP in the moderate group and the severe group were significantly increased,and the LOTCA score was significantly decreased(all P<0.05).Compared with 12 hours after admission,the Tau level,GFAP level and LOTCA score in the same group were significantly increased at 24 hour and 3 day after admission,and there were significant differences in each group(all P<0.05).For the mild,moderate and severe TBI patients,the expression levels of Tau and GFAP were negatively correlated with the LOTCA score(all P<0.05).Conclusion:The levels of Tau and GFAP increased with the severity of TBI patients.At the same time,the expression levels of Tau and GFAP were significantly negatively correlated with the LOTCA scores of mild,moderate and severe TBI patients,suggesting that the levels of Tau and GFAP have positive significance for the evaluation of TBI patients' condition.Dynamic monitoring of Tau and GFAP levels of patients is helpful for timely adjustment of clinical treatment,and has high clinical application value.

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备注/Memo

备注/Memo:
基金项目:陕西省社会发展科技攻关项目(2016SF-257)
更新日期/Last Update: 2023-04-06