[1]钟社兰,陈 星.多囊卵巢综合征与失眠症共病患者临床特征及相关因素分析[J].陕西医学杂志,2023,52(4):437-440.[doi:DOI:10.3969/j.issn.1000-7377.2023.04.016]
　ZHONG Shelan,CHEN Xing.Clinical characteristics and related factors of insomnia in patients with polycystic ovary syndrome[J].,2023,52(4):437-440.[doi:DOI:10.3969/j.issn.1000-7377.2023.04.016]
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多囊卵巢综合征与失眠症共病患者临床特征及相关因素分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年4期
页码:
437-440
栏目:
临床研究
出版日期:
2023-04-05

文章信息/Info

Title:
Clinical characteristics and related factors of insomnia in patients with polycystic ovary syndrome
作者:
钟社兰; 陈 星
(安康市人民医院妇科,陕西 安康 725000)
Author(s):
ZHONG Shelan; CHEN Xing
(Department of Gynecology,Ankang People's Hospital,Ankang 725000,China)
关键词:
多囊卵巢综合征;  失眠症;  临床特征;  相关因素;  肥胖;  胰岛素抵抗指数
Keywords:
Polycystic ovary syndrome;  Insomnia;  Clinical characteristic;  Related factor;  Obesity;  insulin resistance index
分类号:
711.6
DOI:
DOI:10.3969/j.issn.1000-7377.2023.04.016
文献标志码:
A
摘要:
目的:探讨多囊卵巢综合征(PCOS)与失眠症共病患者的临床特征及相关因素。方法:选取因睡眠维持困难就诊的271例PCOS患者,根据患者主诉、病史、匹兹堡睡眠质量指数(PSQI)结果分为单纯PCOS组(183例)与PCOS失眠共病组(88例)。对比分析两组患者临床特征,并分析影响PCOS患者失眠的相关因素。结果:PCOS组和PCOS失眠共病组患者在体重指数(BMI)水平、是否合并基础病(高血压、高脂血症)、是否不孕、Epworth嗜睡量表(ESS)评分及PSQI评分方面比较存在统计学差异(均P<0.05),PCOS失眠共病组患者血孕酮(P)、雌二醇(E2)性激素水平显著低于PCOS组患者,血睾酮(T)性激素水平显著高于PCOS组患者,空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平显著高于PCOS组患者,差异有统计学意义(均P<0.05)。多因素Logistic回归结果显示,肥胖、高T性激素水平、高HOMA-IR是影响PCOS患者合并失眠症的独立危险因素(均P<0.05),高P、E2性激素水平是PCOS患者不易发生失眠症的保护因素(均P<0.05)。结论:肥胖、高T性激素水平、高HOMA-IR是影响PCOS患者合并失眠症的独立危险因素,高P、E2性激素水平是PCOS患者不易发生失眠症的保护因素。
Abstract:
Objective:To explore the clinical characteristics and related factors of insomnia in patients with polycystic ovary syndrome(PCOS).Methods:A total of 271 PCOS patients with difficulty in maintaining sleep were selected.According to the results of chief complaints,medical history and Pittsburgh Sleep Quality Index(PSQI)score,they were divided into PCOS group(183 cases)and PCOS-insomnia group(88 cases).The clinical characteristics of the two groups were compared and analyzed,and the related factors affecting insomnia in PCOS patients were analyzed.Results:There were significant differences in BMI level,underlying diseases(hypertension,hyperlipidemia),infertility,Epworth Sleepiness Scale(ESS)and PSQI scores between the two groups(all P<0.05).The levels of serum progesterone(P)and estradiol(E2)in PCOS-insomnia group were significantly lower than those in PCOS group,and the level of serum T sex hormone was significantly higher than that in PCOS group,and the levels of fasting blood glucose(FBG),fasting insulin(FINS)and insulin resistance index(HOMA-IR)were significantly higher than those in PCOS group(all P<0.05).The results of multivariate Logistic regression analysis showed that obesity,high level of T-sex hormone and high HOMA-IR were independent risk factors of insomnia in PCOS patients,while high levels of P and E2 were protective factors against insomnia(all P<0.05).Conclusion:Obesity,high level of T-sex hormone and high HOMA-IR are independent risk factors of insomnia in PCOS patients,while high levels of P and E2 are protective factors against insomnia.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基础研究计划项目(S2020-JC-YB-1284)
更新日期/Last Update: 2023-04-06