[1]刘湘慧,斯 韬,梁 婷,等.铁死亡发生机制及其在肝细胞癌中的作用研究进展[J].陕西医学杂志,2023,52(3):354-357.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.025]
 LIU Xianghui,SI Tao,LIANG Ting,et al.Mechanism of ferroptosis and its role in hepatocellular carcinoma[J].,2023,52(3):354-357.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.025]
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铁死亡发生机制及其在肝细胞癌中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年3期
页码:
354-357
栏目:
综 述
出版日期:
2023-03-05

文章信息/Info

Title:
Mechanism of ferroptosis and its role in hepatocellular carcinoma
作者:
刘湘慧12斯 韬2梁 婷12覃正萍12
(1.广西中医药大学,广西 南宁 530299; 2.广西中医药大学第三附属医院肿瘤科,广西 柳州 545001)
Author(s):
LIU XianghuiSI TaoLIANG TingQIN Zhengping
(Guangxi University of Traditional Chinese Medicine,Nanning 530299,China)
关键词:
肝细胞癌 铁死亡 铁离子代谢 脂质代谢 氨基酸代谢 脂质过氧化 还原型谷胱甘肽/谷胱甘肽过氧化物酶4信号通路
Keywords:
Hepatocellular carcinoma Ferroptosis Iron metabolism Lipid metabolism Aminoacid metabolism Lipid peroxidation GSH/GPX4 signaling pathway
分类号:
R 735.7
DOI:
DOI:10.3969/j.issn.1000-7377.2023.03.025
文献标志码:
A
摘要:
铁死亡是新近鉴定出的具有铁依赖性的调节性细胞死亡(RCD)模式,依靠铁过载产生的活性氧损坏脂质、核酸和蛋白质,从而使细胞死亡。肝细胞癌(HCC)是中国乃至全球公认的恶性程度高、预后相对较差的恶性肿瘤之一。最近的研究发现细胞内铁代谢紊乱、脂质过氧化物积聚、氨基酸抗氧化系统失衡均是HCC细胞与正常细胞的生理性差异,而这些差异恰好是铁死亡的关键调控因素,因此铁死亡在HCC的发生与发展中具有重要作用。现对铁死亡发生机制及其在HCC中的作用研究进展进行综述,以期为该病提供新的干预靶点。
Abstract:
Ferroptosis is a newly identified iron dependent regulatory cell death(RCD)mode,which relies on reactive oxygen species produced by iron overload to damage lipids,nucleic acids and proteins,thereby causing cell death.Hepatocellular carcinoma(HCC)is recognized as one of the malignant tumors with high degree of malignancy and relatively poor prognosis in China and even the world.Recent studies have found that intracellular iron metabolism disorder,lipid peroxide accumulation,and imbalance of amino acid antioxidant system are all physiological differences between HCC cells and normal cells,and these differences happen to be the key regulatory factors of ferroptosis.Therefore,ferroptosis plays an important role in the occurrence and development of HCC.This article reviews the mechanism of ferroptosis and its role in HCC in order to provide a new intervention target for this disease.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82060856); 广西壮族自治区自然科学基金资助项目(2020JJA140194)
更新日期/Last Update: 2023-03-06