[1]姚向飞,刘 华,蔡 东,等.铁蛋白、钙、磷、甲状旁腺激素水平与维持性血液透析患者预后关系研究[J].陕西医学杂志,2023,52(3):297-300,304.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.011]
　YAO Xiangfei,LIU Hua,CAI Dong,et al.Relationship between ferritin,calcium,phosphorus,parathyroid hormone levels and prognosis of patients with maintenance hemodialysis[J].,2023,52(3):297-300,304.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.011]
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铁蛋白、钙、磷、甲状旁腺激素水平与维持性血液透析患者预后关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年3期
页码:
297-300,304
栏目:
临床研究
出版日期:
2023-03-05

文章信息/Info

Title:
Relationship between ferritin,calcium,phosphorus,parathyroid hormone levels and prognosis of patients with maintenance hemodialysis
作者:
姚向飞1; 刘 华2; 蔡 东1; 权皎洁1; 韦巧宁2
(1.西安高新医院肾脏内科,陕西 西安 710075; 2.西安交通大学第一附属医院血液净化科,陕西 西安 710075)
Author(s):
YAO Xiangfei; LIU Hua; CAI Dong; QUAN Jiaojie; WEI Qiaoning
(Department of Nephrology,Xi'an Gaoxin Hospital,Xi'an 710075,China)
关键词:
维持性血液透析;  铁蛋白;  钙;  磷;  甲状旁腺激素;  预后
Keywords:
Maintenance hemodialysis;  Ferritin;  Calcium;  Phosphorus;  Parathyroid hormone;  Prognosis
分类号:
R 692.5
DOI:
DOI:10.3969/j.issn.1000-7377.2023.03.011
文献标志码:
A
摘要:
目的:探讨铁蛋白、钙、磷、甲状旁腺激素(PTH)水平与维持性血液透析(MHD)患者预后的关系。方法:回顾性分析130例MHD患者临床资料,检测外周血铁蛋白、血红蛋白、白蛋白、肌酐、尿酸、钙、磷、PTH、C-反应蛋白(CRP)水平。保持随访至2021年5月,记录患者生存情况,并对影响MHD患者预后的因素进行Cox回归分析。结果:130例MHD患者死亡51例,存活79例。生存组年龄、透析时间、CRP、铁蛋白、肌酐、尿酸、磷、PTH水平低于死亡组,钙水平高于死亡组(均P<0.05)。不同铁蛋白、钙、磷、PTH水平患者5年生存率比较差异有统计学意义(均P<0.05)。高龄、高铁蛋白、低钙、高磷、高PTH、高CRP水平是MHD患者预后的独立危险因素(均P<0.05)。结论:血清铁蛋白、钙、磷、PTH水平与MHD患者预后密切相关,是影响MHD患者预后的独立危险因素。
Abstract:
Objective:To explore the relationship between ferritin,calcium,phosphorus,parathyroid hormone(PTH)levels and the prognosis of maintenance hemodialysis(MHD)patients.Methods:The clinical data of 130 MHD patients were retrospectively analyzed.The levels of ferritin,hemoglobin,albumin,creatinine,uric acid,calcium,phosphorus,PTH,and CRP in peripheral blood were detected.The patients were followed up until May 2021,and the survival of patients was recorded.Cox regression analysis was used to analyze the factors affecting the prognosis of MHD patients.Results:Among 130 MHD patients,51 patients died and 79 patients survived.The age,dialysis time,CRP,ferritin,creatinine,uric acid,phosphorus and PTH levels of the survival group were lower than those of the death group,and the calcium level was higher than that of the death group(all P<0.05).There were significant differences in 5-year survival rates among patients with different levels of ferritin,calcium,phosphorus and PTH(all P<0.05).Age,high ferritin,low calcium,high phosphorus,high PTH and high CRP levels were independent risk factors for the prognosis of MHD patients(all P<0.05).Conclusion:Serum ferritin,calcium,phosphorus and PTH levels are closely related to the prognosis of MHD patients,and they are independent risk factors for the prognosis of MHD patients.

参考文献/References:

[1] 钱莉莉,鲍皓月,沈元丽,等.祛风汤加减治疗维持性血液透析皮肤瘙痒疗效及对患者肾功能、钙磷代谢的影响[J].陕西中医,2020,41(9):1273-1275.
[2] 张 媛,朱小静.维持性血液透析患者骨硬化蛋白、Klotho蛋白水平变化及与冠状动脉钙化相关性分析[J].陕西医学杂志,2021,50(10):1246-1249.
[3] 司倩楠,建 刚,刘新宇.维持性血液透析患者微炎症状态与铁缺乏的相关性分析[J].山东医药,2020,60(2):69-71.
[4] 朱旻霞,张伟明,倪兆慧,等.维持性血液透析患者透析期血压波动与透析相关并发症的相关性分析[J].上海交通大学学报,2020,40(4):484-488.
[5] 王莉莎,王 丽,谭蓓蓓,等.铁蛋白水平对维持性血液透析患者射血分数长期影响[J].现代预防医学,2019,46(5):130-134.
[6] 贺 丹,葛俭俭,万梓鸣,等.钙磷代谢紊乱对血液透析患者动静脉内瘘球囊扩张术的影响[J].广东医学,2019,40(8):1147-1150.
[7] 葛均波,徐永健.内科学[M].8版.北京:人民卫生出版社,2013:105-107.
[8] 李 丹,谷学梅.血液透析用于慢性肾功能衰竭合并急性心力衰竭临床治疗的价值评价[J].陕西医学杂志,2018,47(9):1161-1163.
[9] 顾 雪,樊英华,张 莉,等.慢性肾功能衰竭脾肾气虚证患者血液透析充分性临床观察[J].陕西中医,2015,36(9):1154-1155.
[10] 李 娜,黄显聪,陈忠坚,等.术前血清铁蛋白水平在评价食管鳞癌患者预后中的价值[J].中华普通外科杂志,2020,35(3):211-214.
[11] 张红梅,高 峰.血清铁蛋白、同型半胱氨酸、叶酸、维生素B12对老年高血压脑室出血患者预后的影响[J].中国老年学杂志,2019,39(7):1568-1571.
[12] 沈薇薇,李宗锋,卜秋宁,等.MPV、PDW、铁蛋白在评估狼疮性肾炎患者肾损伤程度中的价值[J].检验医学,2020,12(1):33-36.
[13] 王明莉,陈德政.维持性血液透析患者血清铁蛋白水平与预后的关系[J].临床肾脏病杂志,2019,19(4):256-260.
[14] Yamaguchi S,Hamano T,Oka T,et al.Electrocardiogram findings at the initiation of hemodialysis and types of subsequent cardiovascular events[J].Hypertens Res,2021,44(5):571-580.
[15] 吴 艳,李永超,钟 杰,等.维持性血液透析患者血清铁蛋白及CD4+T CD8+T细胞与腹主动脉钙化评分的关系[J].西部医学,2021,33(1):120-123,129.
[16] 闫奇奇,郝 丽,张 森.FGF23与CKD患者钙磷代谢及心血管疾病关系研究进展[J].安徽医科大学学报,2019,54(1):158-162.
[17] 李 京,王 怡,李 霞.血液透析联合血液灌流治疗对慢性肾病患者钙磷和脂质代谢的影响[J].重庆医学,2020,49(9):1409-1412.
[18] 于 茜,朱晗玉,龙玲玲,等.骨化三醇口服或静脉给药联合西那卡塞治疗维持性血液透析患者继发性甲状旁腺功能亢进症的疗效观察[J].中华实用诊断与治疗杂志,2020,34(7):678-682.
[19] 姚 晶,徐林芳,吴春蕾,等.饮食健康教育对维持性血液透析患者饮食管理行为、钙磷代谢及营养状况的影响[J].中国健康教育,2020,36(12):1141-1144.
[20] 姜瑞丰,施妙君,鄢巨振.维持性血液透析患者血清Sfrp5、Klotho水平变化及其与钙磷代谢的关系[J].广东医学,2020,41(2):152-155.
[21] 苗鹏伟,默秀婷,田津生,等.不同通量血液透析方式对维持性血液透析患者血中钙磷及全段甲状旁腺激素的影响[J].中国中西医结合急救杂志,2021,38(5):580-583.
[22] 周晓玲,郭一丹,张春霞,等.维持性血液透析患者主动脉弓钙化的相关风险因素及其对远期预后的影响[J].中华肾脏病杂志,2021,37(3):191-197.
[23] 薛亚辉,王 怡.维持性血液透析患者并发心脑血管病的危险因素及对患者近期预后的影响[J].河北医学,2019,25(6):1017-1020.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2019SF-006)
更新日期/Last Update: 2023-03-06