[1]高香转,邸 曼,李 楚,等.血栓弹力图参数与子宫肌瘤病情严重程度关系及对贫血风险的评估价值[J].陕西医学杂志,2023,52(3):278-281,286.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.007]
　GAO Xiangzhuan,DI Man,LI Chu,et al.Relationship between thrombelastography parameters and the severity of uterine fibroidsand its value in evaluating the risk of anemia[J].,2023,52(3):278-281,286.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.007]
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血栓弹力图参数与子宫肌瘤病情严重程度关系及对贫血风险的评估价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年3期
页码:
278-281,286
栏目:
临床研究
出版日期:
2023-03-05

文章信息/Info

Title:
Relationship between thrombelastography parameters and the severity of uterine fibroidsand its value in evaluating the risk of anemia
作者:
高香转1; 邸 曼2; 李 楚3; 任 洁1
(1.陕西省第四人民医院妇产科,陕西 西安 710043; 2.空军军医大学唐都医院妇产科,陕西 西安 710038; 3.陕西省第四人民医院检验科,陕西 西安 710043)
Author(s):
GAO Xiangzhuan; DI Man; LI Chu; REN Jie
(Department of Obstetrics and Gynecology,the Fourth People's Hospital of Shaanxi,Xi'an 710043,China)
关键词:
子宫肌瘤;  血栓弹力图;  凝血功能;  贫血;  相关性
Keywords:
Uterine myoma;  Thrombelastography;  Coagulation function;  Anemia;  Correlation
分类号:
R 737.33
DOI:
DOI:10.3969/j.issn.1000-7377.2023.03.007
文献标志码:
A
摘要:
目的:分析血栓弹力图参数与子宫肌瘤病情严重程度的关系及对贫血风险的评估价值。方法:选择子宫肌瘤患者146例为观察组,另选同期体检健康者146例为对照组。所有研究对象均检测血栓弹力图参数,包括凝血反应时间(R值)、凝血时间(K值)、血细胞凝集块形成速率(α角)、血栓最大弹力度(MA值)和凝血综合指数(CI值)。比较两组血栓弹力图参数,观察血栓弹力图参数在不同直径子宫肌瘤患者中的差异。分析血栓弹力图参数与子宫肌瘤症状严重程度问卷(UFS8)评分的相关性。采用受试者工作特征(ROC)曲线评价血栓弹力图参数对贫血风险的评估价值。结果:观察组R值、K值长于对照组,α角、MA值、CI值小于对照组(均P<0.05)。子宫肌瘤直径>6.0 cm患者R值、K值长于子宫肌瘤直径≤6.0 cm患者,α角、MA值、CI值小于子宫肌瘤直径≤6.0 cm患者(均P<0.05)。经Pearson相关性分析,子宫肌瘤患者UFS8评分与R值、K值呈正相关(r=0.451、0.508,均P<0.05),与α角、MA值、CI值呈负相关(r=-0.348、-0.415、-0.046,均P<0.05)。146例子宫肌瘤患者中发生贫血21例,多因素Logistic回归分析显示R值和K值是子宫肌瘤患者发生贫血的独立预测因素(均P<0.05)。ROC曲线分析显示,子宫肌瘤患者血栓弹力图R值、K值对贫血风险有一定的评估价值,两者联合的评估价值更高(均P<0.001)。结论:血栓弹力图参数与子宫肌瘤病情严重程度相关,其中R值联合K值对贫血风险的评估价值较好。
Abstract:
Objective:To analyze the relationship between thrombelastography parameters and the severity of uterine fibroids and its value in evaluating the risk of anemia.Methods:A total of 146 patients with uterine fibroids were selected as the observation group,and another 146 healthy subjects in the same period were selected as the control group.All subjects were tested for thromboelastography parameters,including coagulation reaction time(R value),coagulation time(K value),hemagglutination block formation rate(α angle),maximal thromboelastic force(MA value),and coagulation composite index(CI value).The parameters of thrombelastography were compared between the two groups,and the differences of the parameters of thrombelastography in uterine fibroids with different diameters were observed.Pearson correlation was used to analyze the correlation between the parameters of thrombelastography and UFS8 score.The ROC curve was used to evaluate the efficacy of thrombelastography parameters in evaluating the risk of anemia.Results:The R value and K value of the observation group were longer than those of the control group,and the α angle,MA value and CI value were lower than those of the control group(all P<0.05).The R and K values of patients with uterine myoma diameter >6.0 cm were longer than those of patients with uterine myoma diameter ≤6.0 cm,and the α angle,MA and CI values were lower than those of patients with uterine myoma diameter ≤6.0 cm(all P<0.05).Pearson correlation analysis showed that UFS8 score was positively correlated with R value and K value(r=0.451,0.508,all P<0.05),and negatively correlated with α angle,MA value and CI value(r=-0.348,-0.415,-0.046,all P<0.05).Among 146 patients with uterine fibroids,21 had anemia.Multivariate Logistic regression analysis showed that R value and K value were independent predictors of anemia in patients with uterine fibroids(all P<0.05).Analysis of ROC curve showed that thrombelastography parameters R and K values were of value in assessing anemia risk in patients with uterine fibroids,and the combination of two had higher value(all P<0.001).Conclusion:There is a strong correlation between thrombelastography parameters and the severity of uterine fibroids,and the R value combined with K value has a good evaluation value on the risk of anemia.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81871182)
更新日期/Last Update: 2023-03-06