[1]焦明娜,霍红艳.氢吗啡酮复合右美托咪啶对老年腹腔镜胃肠道手术患者血流动力学、镇痛效果和不良反应的影响[J].陕西医学杂志,2023,52(2):200-203,207.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.019]
　JIAO Mingna,HUO Hongyan.Effects of hydromorphone combined with dexmedetomidine on hemodynamics,analgesia and adverse reactions in elderly patients with laparoscopic gastrointestinal surgery[J].,2023,52(2):200-203,207.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.019]
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氢吗啡酮复合右美托咪啶对老年腹腔镜胃肠道手术患者血流动力学、镇痛效果和不良反应的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年2期
页码:
200-203,207
栏目:
药物与临床
出版日期:
2023-02-05

文章信息/Info

Title:
Effects of hydromorphone combined with dexmedetomidine on hemodynamics,analgesia and adverse reactions in elderly patients with laparoscopic gastrointestinal surgery
作者:
焦明娜1; 霍红艳2
(1.陕西中医药大学附属医院第一手术麻醉科,陕西 咸阳 712000; 2.西安高新医院麻醉科,陕西 西安 710075)
Author(s):
JIAO Mingna; HUO Hongyan
(The First Department of Surgery and Anesthesia,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
关键词:
腹腔镜手术;  右美托咪啶;  氢吗啡酮;  血流动力学;  术后恢复质量;  镇痛效果;  不良反应
Keywords:
Laparoscopic surgery;  Dexmedetomidine;  Hydromorphone;  Hemodynamic;  Postoperative recovery quality;  Analgesic effect;  Adverse reaction
分类号:
R 614.2
DOI:
DOI:10.3969/j.issn.1000-7377.2023.02.019
文献标志码:
A
摘要:
目的:探究氢吗啡酮复合右美托咪啶对老年腹腔镜胃肠道手术患者血流动力学、镇痛效果和不良反应的影响。目的:选取81例行腹腔镜下胃肠道手术的老年患者,随机分为三组,每组27例。右美托咪啶组静脉泵注0.5 μg/kg右美托咪定,氢吗啡酮组静脉注射15 μg/kg氢吗啡酮,联合用药组静脉注射0.5 μg/kg右美托咪定+15 μg/kg氢吗啡酮,观察各组患者血流动力学指标、术后恢复质量、镇痛效果和不良反应发生情况。结果:①三组患者T0时平均动脉压(MAP)、心率(HR)比较无统计学差异(均P>0.05); 与T0时相比,三组患者T1～T3时MAP、HR降低(均P<0.05),与右美托咪啶组和氢吗啡酮组相比,联合用药组在T1～T3时MAP、HR降低(均P<0.05)。②三组QoR-15评分和MMSE评分比较联合用药组>右美托咪啶组和>氢吗啡酮组(均P<0.05)。③术后不同时间段及同一时间段VAS评分比较联合用药组<氢吗啡酮组<右美托咪啶组(均P<0.05)。④三组循环波动、呼吸抑制、干呕恶心、嗜睡头晕和躁动等不良事件发生率比较联合用药组<右美托咪啶组<氢吗啡酮组(均P<0.05)。结论:氢吗啡酮复合右美托咪啶有利于维持腹腔镜手术患者的血流动力学,镇痛、术后恢复质量较好,VAS评分和不良反应发生率较低,值得临床推广。
Abstract:
Objective:To explore the effects of hydromorphone combined with dexmedetomidine on hemodynamics,analgesia and adverse reactions in elderly patients with laparoscopic gastrointestinal surgery.Methods:A total of 81 elderly patients with laparoscopic surgery of gastrointestinal tract were selected and randomly divided into 3 groups with 27 cases in each.The dexmedetomidine group received intravenous injection of 0.5 μg/kg dexmedetomidine,the hydromorphone group received intravenous injection of 15 μg/kg hydromorphone,and the combination group received intravenous injection of 0.5 μg/kg dexmedetomidine + 15 μg/kg hydromorphone.The hemodynamic indexes,postoperative recovery quality,analgesic effect and adverse reactions in each group were observed.Results:There was no difference in MAP and HR among the three groups at T0(all P>0.05).Compared with T0,the MAP and HR of the three groups decreased at T1 to T3(all P<0.05).Compared with the dexmedetomidine group and hydromorphone group,the MAP and HR of combination group decreased at T1 to T3(all P<0.05).QoR-15 and MMSE scores in combination group were higher than those in other groups,and those of dexmedetomidine group were higher than those of hydromorphone group(all P<0.05).The VAS scores in different time periods and the same time period after operation in combination group were lower than those in other groups,and those of hydromorphone group were lower than those of dexmedetomidine group(all P<0.05).The incidence of adverse events such as circulatory fluctuation,respiratory depression,retching,nausea,drowsiness,dizziness and agitation in combination group was lower than those in other groups,and those of dexmedetomidine group were lower than those of hydromorphone group(all P<0.05).Conclusion:Hydromorphone combined with dexmedetomidine is beneficial to maintain hemodynamics in patients with laparoscopic surgery,has better analgesia,postoperative recovery quality,lower VAS score and incidence of adverse reactions.

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备注/Memo

备注/Memo:
基金项目:西安市科技计划项目[20YXYJ0002(3)]
更新日期/Last Update: 2023-02-06