[1]张 昕,赵 千,王丹丹,等.嗅觉受体家族2亚家族W成员3和增殖细胞核抗原在胶质瘤中的表达及相关性研究[J].陕西医学杂志,2023,52(2):196-199,221.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.018]
　ZHANG Xin,ZHAO Qian,WANG Dandan,et al.Expression and correlation of olfactory receptor family 2 subfamily W member 3 and proliferating cell nuclear antigen in gliomas[J].,2023,52(2):196-199,221.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.018]
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嗅觉受体家族2亚家族W成员3和增殖细胞核抗原在胶质瘤中的表达及相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年2期
页码:
196-199,221
栏目:
临床研究
出版日期:
2023-02-05

文章信息/Info

Title:
Expression and correlation of olfactory receptor family 2 subfamily W member 3 and proliferating cell nuclear antigen in gliomas
作者:
张 昕; 赵 千; 王丹丹; 杜 野
(锦州医科大学附属第一医院,辽宁 锦州 121001)
Author(s):
ZHANG Xin; ZHAO Qian; WANG Dandan; DU Ye
(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
关键词:
胶质瘤;  嗅觉受体家族2亚家族W成员3;  临床特征;  病理;  增殖;  预后
Keywords:
Glioma;  Olfactory receptor family 2 subfamily W member 3;  Clinical features;  Pathology;  Proliferation;  Prognosis
分类号:
R 739.41
DOI:
DOI:10.3969/j.issn.1000-7377.2023.02.018
文献标志码:
A
摘要:
目的:检测嗅觉受体家族2亚家族W成员3(OR2W3)和增殖细胞核抗原(PCNA)在胶质瘤中的表达,探讨其临床意义及相关性,分析其在胶质瘤预后判断中的价值。方法:收集行手术治疗的胶质瘤患者73例为观察组,留取术后组织,取同期因脑外伤行颅内减压患者73例切除边缘正常的脑组织作为对照组。免疫组化检测两组OR2W3和PCNA的表达。结果:免疫组化结果显示OR2W3和PCNA蛋白在观察组中的表达明显高于对照组(P<0.05); OR2W3蛋白在不同肿瘤最大径(71.05%与37.14%)、WHO分级(76.19% 与43.90%)中比较有统计学差异(均P<0.05),PCNA蛋白在不同最大径(94.74% 与 77.14%)、WHO分级(95.24%与 74.19%)中比较有统计学差异(均P<0.05)。OR2W3和PCNA的表达与胶质瘤患者生存时间有关。胶质瘤中OR2W3和PCNA具有正相关性(r=0.65,P=0.029)。结论:胶质瘤患者病变组织中OR2W3和PCNA的表达升高,参与病变的形成和进展。OR2W3与PCNA的表达具有正相关性。检测胶质瘤病变组织中OR2W3和PCNA的表达可预测患者的预后。
Abstract:
Objective:To detect the expression of olfactory receptor family 2 subfamily W member 3(OR2W3)and proliferating cell nuclear antigen(PCNA)in glioma,explore their clinical significance and correlation,and analyze their value in the prognosis of glioma.Methods:Seventy-three patients with glioma who underwent surgical treatment were collected as the observation group,and the postoperative tissues were collected.Seventy-three patients with brain trauma who underwent intracranial decompression during the same period were collected as the control group.The expression of OR2W3 and PCNA in the two groups was detected by immunohistochemistry.Results:The immunohistochemical results showed that OR2W3 and PCNA protein expressions in the observation group were significantly higher than those in the control group(all P<0.05).OR2W3 protein expression was significantly different in different tumor sizes(71.05% vs.37.14%)and WHO grades(76.19% vs.43.90%)(all P<0.05).There were significant differences in PCNA protein expression between patients with different maximum diameters(94.74% vs.77.14%)and WHO grades(95.24% vs.74.19%)(all P<0.05).The expression of OR2W3 and PCNA were related to the survival time of glioma patients.There was a positive correlation between OR2W3 and PCNA in glioma(r=0.65,P=0.029).Conclusion:OR2W3 and PCNA are highly expressed in glioma tissues,which may be involved in the formation and progression of glioma.OR2W3 expression is positively correlated with PCNA expression.Detection of OR2W3 and PCNA expression in glioma tissues can predict the prognosis of patients.

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备注/Memo

备注/Memo:
基金项目:辽宁省科学技术计划项目(20170540334)
更新日期/Last Update: 2023-02-06