[1]李文婷,赵 荣.前列环素、神经肽Y与子痫前期关系及对胎盘早剥的预测价值研究[J].陕西医学杂志,2023,52(2):145-148,175.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.006]
　LI Wenting,ZHAO Rong.Relationship between prostacyclin,neuropeptide Y and preeclampsia and their predictive value for placental abruption[J].,2023,52(2):145-148,175.[doi:DOI:10.3969/j.issn.1000-7377.2023.02.006]
点击复制

前列环素、神经肽Y与子痫前期关系及对胎盘早剥的预测价值研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年2期
页码:
145-148,175
栏目:
临床研究
出版日期:
2023-02-05

文章信息/Info

Title:
Relationship between prostacyclin,neuropeptide Y and preeclampsia and their predictive value for placental abruption
作者:
李文婷1; 赵 荣2
(1.陕西中医药大学第二附属医院产科,陕西 咸阳 712000; 2.安康市妇幼保健院妇产科,陕西 安康 725000)
Author(s):
LI Wenting; ZHAO Rong
(Department of Obstetrics,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
关键词:
子痫前期;  前列环素;  神经肽Y;  严重程度;  胎盘早剥;  预测价值
Keywords:
Preeclampsia;  Prostacyclin;  Neuropeptide Y;  Degree of severity;  Placental abruption;  Predictive value
分类号:
R 714.24
DOI:
DOI:10.3969/j.issn.1000-7377.2023.02.006
文献标志码:
A
摘要:
目的:探讨前列环素、神经肽Y与子痫前期的关系及对胎盘早剥的预测价值。方法:选择120例子痫前期孕妇作为观察组,另选同期的120例正常妊娠孕妇作为对照组。比较两组血清前列环素、神经肽Y水平,分析前列环素、神经肽Y在不同严重程度的子痫前期孕妇中差异性,使用受试者工作特征曲线(ROC)分析前列环素联合神经肽Y对胎盘早剥的预测价值。结果:观察组血清前列环素水平低于对照组,神经肽Y水平高于对照组,两组比较差异均有统计学意义(均P<0.05); 重度子痫前期组血清前列环素水平低于轻度子痫前期组,神经肽Y水平高于轻度子痫前期组,两组比较差异均有统计学意义(均P<0.05); 经Pearson相关性分析,子痫前期孕妇24 h尿蛋白定量、血液黏度、红细胞压积与前列环素呈负相关(均P<0.05),与神经肽Y呈正相关(均P<0.05),血红蛋白、血小板计数与前列环素呈正相关(均P<0.05),与神经肽Y呈负相关(均P<0.05); 经ROC曲线分析,血清前列环素联合神经肽Y预测子痫前期孕妇发生胎盘早剥的AUC为0.914。结论:子痫前期孕妇血清前列环素表达下调,神经肽Y表达上调,可能参与病情进展,两者联合预测胎盘早剥的效能较好。
Abstract:
Objective:To analyze the relationship between prostacyclin,neuropeptide Y and preeclampsia and their predictive value for placental abruption.Methods:A total of 120 pregnant women with preeclampsia were selected as the observation group,and 120 normal pregnant women in the same period were selected as the control group.The serum levels of prostacyclin and neuropeptide Y were compared between the two groups,and the differences of prostacyclin and neuropeptide Y in pregnant women with different severity of preeclampsia were analyzed.The predictive value of prostacyclin combined with neuropeptide Y in placental abruption was analyzed by receiver operating characteristic(ROC)curve.Results:The level of prostacyclin in the observation group was lower than that in the control group,and the level of neuropeptide Y was higher than that in the control group(all P<0.05).The level of serum prostacyclin in severe preeclampsia group was lower than that in mild preeclampsia group,and the level of neuropeptide Y was higher than that in mild preeclampsia group(all P<0.05).Pearson correlation analysis showed that 24-hour urine protein quantification,blood viscosity and hematocrit were negatively correlated with prostacyclin and positively correlated with neuropeptide Y(all P<0.05); hemoglobin and platelet count were positively correlated with prostacyclin,and negatively correlated with neuropeptide Y(all P<0.05).ROC curve analysis showed that the AUC of serum prostacyclin combined with neuropeptide Y in predicting placental abruption in preeclamptic women was 0.914.Conclusion:The down-regulation of prostacyclin and neuropeptide Y in preeclampsia may be involved in the progression of the disease,the combination of prostacyclin and neuropeptide Y is effective in predicting placental abruption.

参考文献/References:

[1] 贾雪芹,孙梅玲,郑加翠,等.子痫前期预测研究进展[J].陕西医学杂志,2020,49(8):1053-1057.
[2] 邓兴宇,杨 楠,薛宇廷,等.基于危险因素和常规实验室指标的子痫前期风险预测模型研究[J].临床检验杂志,2021,39(8):566-572.
[3] 黄丽琼,郑 波,张元珍,等.2-甲氧雌二醇在早发型子痫前期患者中的表达及临床意义[J].陕西医学杂志,2019,48(2):208-212.
[4] Klinjampa R,Sitticharoon C,Souvannavong-Vilivong X,et al.Placental neuropeptide Y(NPY)and NPY receptors expressions and serum NPY levels in preeclampsia[J].Experimental Biology & Medicine,2019,244(5):380-388.
[5] Lu D,Peng Q,Chen D,et al.Expression imbalance of IL-17/IL-35 in peripheral blood and placental tissue of pregnant women in preeclampsia[J].Taiwanese Journal of Obstetrics and Gynecology,2020,59(3):409-414.
[6] 中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2020)[J].中华妇产科杂志,2020,55(4):227-238.
[7] 谢 宁,李红岩,韩晓云.加味杞菊地黄汤联合西药治疗子痫前期疗效及对患者外周血sFlt/PIGF和妊娠结局的影响[J].陕西中医,2021,42(9):1189-1192.
[8] Cerdeira AS,Vatish M,Lecarpentier E.One step closer to a cure for preeclampsia:Boosting the natural affinity of VEGF to sFlt-1[J].Hypertension,2020,76(4):1081-1083.
[9] Cerdeira AS,Rana S,Karumanchi SA.Is prolonging gestation in preeclampsia for better or worse in preventing cardiovascular disease?[J].Hypertension,2021,78(5):1395-1397.
[10] Bakouei F,Delavar MA,Mashayekh-Amiri S,et al.Efficacy of n-3 fatty acids supplementation on the prevention of pregnancy induced-hypertension or preeclampsia:A systematic review and meta-analysis[J].Taiwanese Journal of Obstetrics and Gynecology,2020,59(1):8-15.
[11] Curtin K,Theilen LH,Fraser A,et al.Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life[J].Hypertension in Pregnancy,2019,38(3):141-148.
[12] 胡凤丽.子痫前期孕妇动脉弹性与氧化应激损伤、血管内皮功能的相关性[J].中国计划生育学杂志,2021,29(6):1282-1285.
[13] Makieieva N,Odynets Y,Yavorovych M,et al.Serum levels of monocyte chemotactic protein-1 and nitrogen oxide metabolites in henoch-schnlein purpura indicate the development of renal syndrome[J].The Indian Journal of Pediatrics,2020,87(10):863-864.
[14] Viktorinova A.Potential clinical utility of macrophage colony-stimulating factor,monocyte chemotactic protein-1 and myeloperoxidase in predicting atherosclerotic plaque instability[J].Discovery Medicine,2019,28(155):237-245.
[15] 王姊文,符 平.超声测定子痫前期孕妇心肌功能指数与子宫动脉血流搏动指数、子宫动脉阻力指数的相关性及联合预测胎盘早剥的价值[J].中国性科学,2021,30(10):91-95.
[16] 王娜娜,唐增军,于 璨,等.妊娠期高血压疾病患者发生胎盘早剥预测模型的建立与评价[J].现代妇产科进展,2020,29(10):752-755.
[17] 李俊良.子痫前期严重并发症的防治[J].中国药物经济学,2014,12(2):245-246.
[18] Han M,Liu D,Zeb S,et al.Are maternal and neonatal outcomes different in placental abruption between women with and without preeclampsia[J].Placenta,2019,85(15):69-73.
[19] 杨子月.血清D-二聚体、胎盘生长因子与重度子痫前期患者胎盘早剥的关系分析[J].现代诊断与治疗,2022,33(3):425-427.
[20] 刘 凤.重度子痫前期合并胎盘早剥的临床特征及其对母婴结局的影响[J].中国社区医师,2020,36(32):46-47.

相似文献/References:

[1]黄丽琼,郑 波△,张元珍,等.2甲氧雌二醇在早发型子痫前期患者中的表达及临床意义*[J].陕西医学杂志,2019,(2):208.
　HUANG Liqiong,ZHENG Bo,ZHANG Yuanzhen,et al.The expression and clinical significances of 2methoxyestradiol in earlyonset preeclampsia[J].,2019,(2):208.
[2]齐红燕,郭海燕,杨爱君.小剂量阿司匹林对子痫前期的预防作用及安全性研究*[J].陕西医学杂志,2019,(4):528.
[3]贾雪芹,孙梅玲△,郑加翠,等.子痫前期预测研究进展[J].陕西医学杂志,2020,49(8):1053.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.035]
[4]张 丽,赵莉娜,彭 静,等.子痫前期孕妇血清白细胞介素17、和肽素及血小板内皮细胞黏附分子1水平检测及临床意义[J].陕西医学杂志,2020,49(11):1515.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.038]
　ZHANG Li,ZHAO Lina,PENG Jing,et al.Detection and significance of serum IL-17,CPT and PECAM-1 in pregnant women with preeclampsia[J].,2020,49(2):1515.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.038]
[5]席翠萍,杨 洁.孕中期水通道蛋白1、白细胞介素37表达水平对高危孕妇发生子痫前期的预测价值[J].陕西医学杂志,2022,51(11):1364.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.010]
[6]崔 静,朱俊美,张 燕.血管内皮功能指标与子痫前期严重程度关系及对孕妇流产预测效能研究[J].陕西医学杂志,2023,52(5):608.[doi:DOI:10.3969/j.issn.1000-7377.2023.05.026]
　CUI Jing,ZHU Junmei,ZHANG Yan.Relationship between vascular endothelial function indexes and the severity of preeclampsia and its predictive efficacy for abortion[J].,2023,52(2):608.[doi:DOI:10.3969/j.issn.1000-7377.2023.05.026]
[7]连亚楠,贺同强,乔 媛,等.子痫前期患者发生视网膜脱离危险因素分析[J].陕西医学杂志,2024,(6):793.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.015]
　LIAN Yanan,HE Tongqiang,QIAO Yuan,et al.Analysis of risk factors for retinal detachment in patients with preeclampsia[J].,2024,(2):793.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.015]
[8]郭 瑜,周永红,魏 丹,等.子痫前期孕妇微小RNA-210-5p和整合素αM表达水平及检测意义[J].陕西医学杂志,2024,(11):1552.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.025]
　GUO Yu,ZHOU Yonghong,WEI Dan,et al.Expression levels and detection significance of miR-210-5p and integrin αM in pregnant women with preeclampsia[J].,2024,(2):1552.[doi:DOI:10.3969/j.issn.1000-7377.2024.11.025]
[9]赵丽红,王晨曦,赵 英,等.胎盘蛋白13在子痫前期发生中的作用及相关药物治疗研究进展[J].陕西医学杂志,2025,54(2):282.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.029]
　ZHAO Lihong,WANG Chenxi,ZHAO Ying,et al.Research progress on the role of placental protein 13 in the development of preeclampsia and related drug treatment[J].,2025,54(2):282.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.029]

备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2021SF-312)
更新日期/Last Update: 2023-02-06