[1]焦向宁,董维平,路 璐,等.浅表性膀胱癌经尿道膀胱癌等离子电切术治疗后患者氧化应激反应水平与疼痛相关性研究[J].陕西医学杂志,2023,52(1):32-35.[doi:DOI:10.3969/j.issn.1000-7377.2023.01.007]
　JIAO Xiangning,DONG Weiping,LU Lu,et al.Correlation between oxidative stress and pain after transurethral resection of bladder cancer in patients with superficial bladder cancer[J].,2023,52(1):32-35.[doi:DOI:10.3969/j.issn.1000-7377.2023.01.007]
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浅表性膀胱癌经尿道膀胱癌等离子电切术治疗后患者氧化应激反应水平与疼痛相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
52
期数:
2023年1期
页码:
32-35
栏目:
临床研究
出版日期:
2023-01-05

文章信息/Info

Title:
Correlation between oxidative stress and pain after transurethral resection of bladder cancer in patients with superficial bladder cancer
作者:
焦向宁1; 董维平1; 路 璐1; 马 江1; 张璞暹1; 郅玲然2
(1.武警陕西省总队医院泌尿外科,陕西 西安 710054; 2.西安市人民医院 西安市第四医院病理诊断中心,陕西 西安710004)
Author(s):
JIAO Xiangning; DONG Weiping; LU Lu; MA Jiang; ZHANG Puxian; ZHI Lingran
(Department of Urology,Shaanxi Provincial Corps Hospital of the Armed Police,Xi'an 710054,China)
关键词:
浅表性膀胱癌;  手术疗法;  经尿道膀胱肿瘤电切术;  疼痛;  术后;  氧化应激
Keywords:
Superficial bladder cancer;  Surgical therapy;  Transurethral resection of bladder tumor;  Pain;  Postoperative;  Oxidative stress
分类号:
R 737.14
DOI:
DOI:10.3969/j.issn.1000-7377.2023.01.007
文献标志码:
A
摘要:
目的:探究浅表性膀胱癌患者经尿道膀胱癌等离子电切术(TURBT)后氧化应激水平与疼痛的相关性。方法:收集98例预接受TURBT治疗的浅表性膀胱癌患者为研究对象。评估患者术后疼痛视觉模拟量表评分(VAS),测定比较术前和术后血清疼痛介质[前列腺素E2(PGE2)、P物质(SP)]和氧化应激指标[丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)]水平。分析氧化应激指标与疼痛程度和疼痛介质水平的相关性。结果:患者均顺利完成手术治疗。术后24 h的VAS评分、血清PGE2、SP、MDA、ROS水平显著高于术前,术后72 h显著低于术后24 h,但高于术前(均P<0.01); 术后24 h的SOD水平显著低于术前,术后72 h高于术后24 h,但低于术前(均P<0.01)。术后不同疼痛程度患者血清PGE2、SP、MDA、ROS和SOD水平间比较,差异具有统计学意义(均P<0.01),术后24 h和72 h中重度疼痛者血清PGE2、SP、MDA、ROS水平>轻度疼痛者>舒适者,中重度疼痛者血清SOD<轻度疼痛者<舒适者(均P<0.01)。Pearson相关分析显示,术后患者血清MDA和ROS表达水平与PGE2、SP水平呈正相关,血清SOD与之呈负相关(均P<0.05)。结论:TURBT会刺激浅表性膀胱癌体内疼痛介质表达,引发术后早期不同程度痛感,且患者术后机体氧化应激状态与疼痛评分和疼痛介质表达水平密切相关。
Abstract:
Objective:To explore the relationship between oxidative stress and pain after transurethral resection of bladder cancer(TURBT)in patients with superficial bladder cancer.Methods:A total of 98 patients with superficial bladder cancer who were pretreated with TURBT were collected.The postoperative pain Visual Analog Scale(VAS)score was evaluated,and the preoperative and postoperative serum pain mediators [prostaglandin E2(PGE2),substance P(SP)]and oxidative stress indicators [malondialdehyde(MDA),reactive oxygen species(ROS),superoxide dismutase(SOD)]levels were measured and compared.The correlation between oxidative stress indicators and pain severity,pain mediator levels was analyzed.Results:All patients successfully completed the surgical treatment.The 24-hour postoperative VAS score,serum PGE2,SP,MDA and ROS levels were significantly higher than those before surgery,and those 72 hours after surgery were lower than those 24 hours after surgery,but higher than those before surgery(all P<0.01).The 24-hour postoperative SOD level was significantly lower than that before surgery,and that 72 hours after surgery were higher than that 24 hours after surgery,but lower than that before surgery(all P<0.01).There were significant differences in the levels of serum PGE2,SP,MDA,ROS and SOD in patients with different pain degrees after operation(all P<0.01),and the levels of serum PGE2,SP,MDA and ROS in patients with moderate to severe pain at 24 and 72 hours after operation> mild pain> comfortable,moderate to severe pain serum SOD < mild pain < comfortable(all P<0.01).Pearson correlation analysis showed that the expression levels of serum MDA and ROS in postoperative patients were positively correlated with the levels of PGE2 and SP,and serum SOD was negatively correlated with the levels of PGE2 and SP(all P<0.05).Conclusion:TURBT can stimulate the expression of pain mediators in superficial bladder cancer,cause different degrees of pain in the early postoperative period,and the postoperative oxidative stress state of patients is closely related to the pain score and the expression level of pain mediators.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基础研究计划-重大基础研究项目(2016ZDJC-12); 西安市第四医院科研孵化基金资助项目(FZ-17)
更新日期/Last Update: 2022-12-28