[1]朱绍华,何创业,赵 芯.圆柱瘤蛋白、白细胞介素-6、白细胞介素-8在结直肠癌及癌前病变中的表达差异及其与患者临床病理特征的关系[J].陕西医学杂志,2022,51(12):1602-1606.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.032]
　ZHU Shaohua,HE Chuangye,ZHAO Xin.Expression differences of cylindroma protein,IL-6 and IL-8 in colorectal cancer and precancerous lesions and their correlation with clinicopathological characteristics of patients[J].,2022,51(12):1602-1606.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.032]
点击复制

圆柱瘤蛋白、白细胞介素-6、白细胞介素-8在结直肠癌及癌前病变中的表达差异及其与患者临床病理特征的关系
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年12期
页码:
1602-1606
栏目:
临床病理
出版日期:
2022-12-05

文章信息/Info

Title:
Expression differences of cylindroma protein,IL-6 and IL-8 in colorectal cancer and precancerous lesions and their correlation with clinicopathological characteristics of patients
作者:
朱绍华; 何创业; 赵 芯
(空军军医大学西京医院消化内科,陕西 西安 710032)
Author(s):
ZHU Shaohua; HE Chuangye; ZHAO Xin
(Department of Gastroenterology,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
关键词:
结直肠癌;  圆柱瘤蛋白;  白细胞介素-6;  白细胞介素-8;  癌前病变;  临床病理特征
Keywords:
Colorectal cancer;  Cylindroma protein;  IL-6;  IL-8;  Precancerous lesions;  Clinicopathological characteristics
分类号:
R 735.34
DOI:
DOI:10.3969/j.issn.1000-7377.2022.12.032
文献标志码:
A
摘要:
目的:探究结直肠癌(CRC)及癌前病变患者组织标本中圆柱瘤蛋白(CYLD)、白细胞介素-6(IL-6)及IL-8的表达状况及其与患者临床病理特征的关系。方法:选取CRC患者70例、低级别上皮内瘤变(LGIN)患者35例和高级别上皮内瘤变(HGIN)患者35例,分别纳入CRC组、LGIN组和HGIN组,同时选取体检健康者70例纳入正常组(N组)。比较各组CYLD、IL-6、IL-8表达情况,分析CYLD、IL-6、IL-8与CRC患者临床病理特征的相关性以及CYLD与IL-6、IL-8表达的相关性。结果:四组CYLD、IL-6、IL-8阳性表达率比较,差异有统计学意义(均P<0.05)。CYLD、 IL-6、IL-8表达在CRC患者性别、年龄及肿瘤位置方面比较差异无统计学意义(均P>0.05),在临床分期、肿瘤浸润深度、淋巴结转移等方面比较差异有统计学意义(均P<0.05)。Spearman相关性分析结果显示,CRC患者CYLD与IL-6、IL-8表达呈现负相关(r=-0.765、-0.289,均P<0.05)。结论:随着结直肠病变程度的加深,CYLD 的表达呈现下调趋势,IL-6、IL-8的表达均呈上调趋势; 同时在CRC患者组织标本中,CYLD、IL-6、IL-8的表达均与临床分期、肿瘤浸润深度及淋巴结转移存在显著关联,且CYLD的表达受到抑制可能会上调IL-6、IL-8的表达,从而加速CRC的发展。
Abstract:
Objective:To investigate the expression of cylindroma protein(CYLD),IL-6 and IL-8 in colorectal cancer(CRC)and precancerous lesions and their correlation with clinicopathological characteristics of patients.Methods:Seventy patients with CRC,thirty-five patients with low-grade intraepithelial neoplasia(LGIN)and thirty-five patients with high-grade intraepithelial neoplasia(HGIN)were selected into CRC group,LGIN group and HGIN group respectively,and seventy healthy subjects were selected into normal group(group N).The expression of CYLD,IL-6 and IL-8 in each group was compared,and the correlation between CYLD,IL-6,IL-8 and clinicopathological characteristics of CRC patients and between CYLD and IL-6,IL-8 expression was analyzed.Results:The positive expression rates of CYLD,IL-6 and IL-8 in the four groups were significantly different(all P<0.05).There was no significant difference in the expression of CYLD,IL-6 and IL-8 in sex,age and tumor location of CRC patients(all P>0.05),but there was significant difference in clinical stage,tumor invasion depth and lymph node metastasis(all P<0.05).Spearman correlation analysis showed that CYLD was negatively correlated with IL-6 and IL-8 expression in CRC patients(r=-0.765,-0.289,all P<0.05).Conclusion:With the deepening of colorectal lesions,the expression of CYLD showed a downward trend,and the expressions of IL-6 and IL-8 showed an upward trend.At the same time,in tissue specimens of colorectal cancer patients,the expressions of CYLD,IL-6 and IL-8 were significantly correlated with clinical stage,tumor invasion depth and lymph node metastasis.In addition,the inhibition of CYLD expression may increase the expression of IL-6 and IL-8,thereby accelerating the development of colorectal cancer.

参考文献/References:

[1] Unterleuthner D,Neuhold P,Schwarz K,et al.Cancer-associated fibroblast-derived Wnt2 increases tumor angiogenesis in colon cancer[J].Angiogenesis,2020,23(2):159-177.
[2] 林增海,陆 军,王凯松.槲皮素对5-FU诱导的结直肠癌SW480细胞耐药及自噬调控机制研究[J].陕西中医,2021,42(10):1338-1343.
[3] Jeon J,Du M,Schoen RE,et al.Determining risk of colorectal cancer and starting age of screening based on lifestyle,environmental,and genetic factors[J].Gastroenterology,2018,154(8):2152-2164.
[4] 何 瑜,唐宽平,马晓颖.5-钙黏蛋白、基质金属蛋白酶9在结直肠癌组织中的表达及临床意义[J].陕西医学杂志,2021,50(5):618-621.
[5] 吴昭利,李成军,李仁廷,等.通麻汤联合穴位注射治疗结直肠癌奥沙利铂化疗相关外周神经毒性疗效研究[J].陕西中医,2019,40(9):1247-1250.
[6] 章玉玲,周 岳.结直肠癌患者血清循环肿瘤细胞、糖类抗原24-2、糖类抗原19-9水平及其与临床病理特征关系[J].陕西医学杂志,2022,51(3):322-324,329.
[7] 杨 校,安冬洁,高春辰,等.去泛素化酶圆柱瘤基因调控肝脏相关疾病的研究进展[J].中华肝脏病杂志,2019,27(6):477-480.
[8] Sun Q,Shang Y,Sun F,et al.Interleukin-6 promotes epithelial-mesenchymal transition and cell invasion through integrin β6 upregulation in colorectal cancer[J].Oxid Med Cell Longev,2020,2020:8032187.
[9] Zheng T,Ma G,Tang M,et al.IL-8 secreted from M2 macrophages promoted prostate tumorigenesis via STAT3/MALAT1 pathway[J].International Journal of Molecular Sciences,2018,20(1):98.
[10] 赵 旭,仝 聪,李 毅,等.微小RNA-10a联合甲胎蛋白、糖类抗原50、糖类抗原19-9检测在结直肠腺癌早期诊断中的价值[J].陕西医学杂志,2022,51(1):96-99.
[11] 李子银,习隽丽,吕志华,等.miR-130a调控肿瘤抑制因子对结直肠癌细胞生物学行为的影响[J].现代消化及介入诊疗,2021,26(4):454-459.
[12] Jo M,Kwon JH,Joo YH,et al.Sa1203-inhibitory effect of cancer stem cells by α-mangostin in colorectal cancer[J].Gastroenterology,2018,154(6):276.
[13] Yang X,Sun Y,Zhang Y,et al.Downregulation of miR-181b inhibits human colon cancer cell proliferation by targeting CYLD and inhibiting the NF-κB signaling pathway[J].International Journal of Molecular Medicine,2020,46(5):1755-1764.
[14] Xie S,Wu Y,Hao H,et al.CYLD deficiency promotes pancreatic cancer development by causing mitotic defects[J].Journal of Cellular Physiology,2019,234(6):9723-9732.
[15] 苗 瑞.CYLD及IL-6在结直肠癌及癌前病变中的表达及临床意义[D].佳木斯:佳木斯大学,2021.
[16] Heichler C,Scheibe K,Schmied A,et al.STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis[J].Gut,2020,69(7):1269-1282.
[17] 蔡东林,孙钟和,赵益庆.慢性阻塞性肺疾病稳定期BODE指数、IL-8、TNF-α水平与肺肾气虚证相关性研究[J].陕西中医,2020,41(11):1573-1575.
[18] 李 瑾.CYLD、IL-8在结直肠癌前病变与结直肠癌中的表达及临床意义的初步研究[D].开封:河南大学,2019.
[19] 唐淑丽,何匡邦,张纯慧,等.胃癌组织中miR-320a和CYLD的表达及与临床病理特征及预后的关系[J].实用肿瘤学杂志,2018,32(6):538-544.
[20] Zhang L,Zhou JJ,Luo C.CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-κB activation[J].Arthritis Research & Therapy,2018,20(1):219.

相似文献/References:

[1]柯东平,毛俊倩,刘 琪,等.TRIM21调控人结直肠癌细胞增殖分子机制研究*[J].陕西医学杂志,2019,(6):691.
　KE Dongping,MAO Junqian,LIU Qi,et al.Study on molecular mechanisms of TRIM21 in regulating proliferation of colorectal cancer[J].,2019,(12):691.
[2]张 慧,陈景志,陈建立△,等.DCC和MKK4基因在结直肠癌组织中的表达及临床意义*[J].陕西医学杂志,2019,(8):968.
　ZHANG Hui,CHEN Jingzhi,CHEN Jianli,et al.Expression and clinical significance of DDC and MKK4 genes in colorectal cancer tissue[J].,2019,(12):968.
[3]高怀军,余 伟.腹腔镜结直肠癌根治术治疗结直肠癌临床疗效及对患者胃肠功能的影响[J].陕西医学杂志,2019,(8):990.
　GAO Huaijun,YU Wei..Clinical study of laparoscopic radical resection in the treatment of colorectal cancer in and its influence on gastrointestinal function[J].,2019,(12):990.
[4]赵英旋,白玉勤.结直肠癌患者肿瘤出芽情况与临床病理特征、程序性死亡受体1及程序性死亡配体1表达相关性研究[J].陕西医学杂志,2021,50(6):747.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.027]
　ZHAO Yingxuan,BAI Yuqin.Correlation between tumor budding and clinicopathological characteristics,expression of PD-1 and PD-L1 in CRC[J].,2021,50(12):747.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.027]
[5]马 骞,朱 军,蔡梦珊,等.基于exoRBase外泌体数据库结直肠癌竞争性内源RNA网络构建及富集分析[J].陕西医学杂志,2021,50(7):797.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.007]
　MA Qian,ZHU Jun,CAI Mengshan,et al.Construction and enrichment analysis of competing endogenous RNA network for colorectal cancer based on the exoRBase database[J].,2021,50(12):797.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.007]
[6]章玉玲,周 岳.结直肠癌患者血清循环肿瘤细胞、糖类抗原24-2、糖类抗原19-9水平及其与临床病理特征关系[J].陕西医学杂志,2022,51(3):322.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.013]
　ZHANG Yuling,ZHOU Yue.Serum circulating tumor cells,carbohydrate antigen 24-2 and carbohydrate antigen 19-9 levels in patients with colorectal cancer and their relationship with clinicopathological features[J].,2022,51(12):322.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.013]
[7]张利伟,胡海燕.粪便硫酸类肝素蛋白多糖2与分泌型卷曲相关蛋白2基因甲基化检测在结直肠癌筛查中的应用价值[J].陕西医学杂志,2022,51(3):366.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.024]
　ZHANG Liwei,HU Haiyan.Application value of feces detection of syndecan-2 and secreted frizzled related protein 2 gene methylation in colorectal cancer screening[J].,2022,51(12):366.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.024]
[8]曹巍巍,郭修田.结直肠癌原位移植造模技术研究进展[J].陕西医学杂志,2022,51(6):764.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.029]
　CAO Weiwei,GUO Xiutian.Research progress of orthotopic transplantation technology for colorectal cancer[J].,2022,51(12):764.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.029]
[9]张言言,韩 刚,曹 羽,等.同源盒基因10调控胰岛素样生长因子结合蛋白3与肠癌细胞5-氟尿嘧啶抵抗的关系研究[J].陕西医学杂志,2022,51(7):771.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.001]
　ZHANG Yanyan,HAN Gang,CAO Yu,et al.Relationship between regulation of IGFBP3 by HOXD10 and 5-fluorouracil resistance in colorectal cancer cells[J].,2022,51(12):771.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.001]
[10]张晓峰,冯 景,季飞燕,等.结直肠癌术后辅助化疗患者肠内营养不耐受影响因素及小野寺预后营养指数预测价值分析[J].陕西医学杂志,2022,51(9):1114.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.016]

备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(S2020-YF-YBSF-1186)
更新日期/Last Update: 2022-12-05