[1]李 妍,张合成,王国锋,等.外周血中性粒细胞与淋巴细胞比值、淋巴细胞与单核细胞比值对患儿急性髓系白血病疗效及预后的评估价值[J].陕西医学杂志,2022,51(12):1516-1519.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.011]
　LI Yan,ZHANG Hecheng,WANG Guofeng,et al.Value of peripheral blood NLR and LMR in evaluating the efficacy and prognosis of children with acute myeloid leukemia[J].,2022,51(12):1516-1519.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.011]
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外周血中性粒细胞与淋巴细胞比值、淋巴细胞与单核细胞比值对患儿急性髓系白血病疗效及预后的评估价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年12期
页码:
1516-1519
栏目:
临床研究
出版日期:
2022-12-05

文章信息/Info

Title:
Value of peripheral blood NLR and LMR in evaluating the efficacy and prognosis of children with acute myeloid leukemia
作者:
李 妍1; 张合成2; 王国锋1; 范朋凯1
(1.郑州大学附属儿童医院血液病研究室,河南 郑州 450002; 2.郑州大学附属儿童医院烧伤整形科,河南 郑州 450002)
Author(s):
LI Yan; ZHANG Hecheng; WANG Guofeng; FAN Pengkai
(Blood Disease Laboratory,Children's Hospital Affiliated to Zhengzhou University,Zhengzhou 450002,China)
关键词:
急性髓系白血病;  中性粒细胞与淋巴细胞比值;  淋巴细胞与单核细胞比值;  完全缓解;  无复发生存率;  儿童
Keywords:
Acute myeloid leukemia;  Neutrophil to lymphocyte ratio;  Lymphocyte to monocyte ratio;  Complete remission;  Relapse-free survival rate;  Children
分类号:
R 557
DOI:
DOI:10.3969/j.issn.1000-7377.2022.12.011
文献标志码:
A
摘要:
目的:探讨外周血中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)对患儿急性髓系白血病(AML)疗效及预后的评估价值。方法:纳入97例AML患儿为AML组,并选取同期一般资料相匹配的体检健康儿童90例为对照组。根据血常规计算NLR、LMR水平。比较两组初诊时实验室指标,包括白细胞计数(WBC)、NLR、LMR、血红蛋白和血小板计数。比较AML患儿初诊时与治疗1个疗程后NLR、LMR水平。根据初诊时NLR、LMR水平将AML患儿分为NLR高表达组(46例)与NLR低表达组(51例)、LMR高表达组(53例)与LMR低表达组(44例),分析NLR、LMR水平与AML患儿临床特征及实验室指标的相关性,并比较不同NLR、LMR水平AML患儿短期疗效。采用Kaplan-Meier法分析NLR、LMR水平与AML患儿预后的关系。结果:与对照组相比,AML组患儿WBC、NLR水平升高,LMR、血红蛋白、血小板计数水平降低(均P<0.05)。与初诊时相比,治疗1个疗程后AML患儿NLR水平降低,LMR水平升高(均P<0.05)。NLR、LMR水平与AML患儿性别、年龄、WBC、血红蛋白、血小板计数无相关性(均P>0.05)。NLR低表达组完全缓解(CR)率高于NLR高表达组,LMR高表达组CR率高于LMR低表达组(均P<0.05)。NLR高表达组3年无复发生存率低于NLR低表达组,LMR高表达组3年无复发生存率高于LMR低表达组(均P<0.05)。结论:外周血NLR、LMR水平对AML患儿疗效及长期预后具有良好的评估价值。
Abstract:
Objective:To explore the value of peripheral blood neutrophil to lymphocyte ratio(NLR)and lymphocyte to monocyte ratio(LMR)in evaluating the efficacy and prognosis of children with acute myeloid leukemia(AML).Methods:A total of 97 children with AML were included as AML group,and another 90 healthy children who matched the general data were regarded as the control group.The NLR and LMR were calculated according to the blood routine.Laboratory parameters at the time of initial diagnosis,including WBC,NLR,LMR,hemoglobin and platelet count,were compared between two groups.The levels of NLR and LMR in children with AML at the time of initial diagnosis and after one course of treatment were compared.Children with AML were divided into high NLR expression group(46 cases)and low NLR expression group(51 cases),high LMR expression group(53 cases)and low LMR expression group(44 cases)according to NLR and LMR levels at the time of initial diagnosis,and the correlation between NLR,LMR levels and clinical characteristics and laboratory parameters of children with AML was analyzed,and the short-term efficacy of children with AML at different NLR and LMR levels was compared.The Kaplan-Meier method was used to analyze the relationship between NLR,LMR levels and the prognosis of children with AML.Results:Compared with the control group,the levels of WBC and NLR in AML group increased,and the levels of LMR,hemoglobin and platelet count decreased(all P<0.05).After one course of treatment,the level of NLR was decreased and the level of LMR was increased in children with AML compared with those at the time of initial diagnosis(all P<0.05).There was no correlation between NLR,LMR levels and sex,age,WBC,hemoglobin and platelet count in children with AML(all P>0.05).The rate of complete remission(CR)in low NLR expression group was higher than that in high NLR expression group,and the CR rate in high LMR expression group was higher than that in low LMR expression group(all P<0.05).The 3-year relapse-free survival rate in high NLR expression group was lower than that in low NLR expression group,and the 3-year relapse-free survival rate in high LMR expression group was higher than that in low LMR expression group(all P<0.05).Conclusion:The levels of NLR and LMR in peripheral blood have good evaluation value for the curative effect and long-term prognosis of children with AML.

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备注/Memo

备注/Memo:
基金项目:河南省医学科技攻关计划联合共建项目(LHGJ20210659)
更新日期/Last Update: 2022-12-05