[1]康卫卫,黄剑磊,马 媛,等.子宫内膜息肉患者经宫腔镜子宫内膜息肉切除术后不同促排卵方案对体外受精/卵细胞质内单精子注射助孕后新鲜胚胎移植临床妊娠率的影响[J].陕西医学杂志,2022,51(12):1505-1510.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.009]
　KANG Weiwei,HUANG Jianlei,MA Yuan,et al.Effect of different controlled ovarian stimulation methods on clinical pregnancy rate of fresh cycle embryo transferafter IVF/ICSI for patients with EPs after TCRP[J].,2022,51(12):1505-1510.[doi:DOI:10.3969/j.issn.1000-7377.2022.12.009]
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子宫内膜息肉患者经宫腔镜子宫内膜息肉切除术后不同促排卵方案对体外受精/卵细胞质内单精子注射助孕后新鲜胚胎移植临床妊娠率的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年12期
页码:
1505-1510
栏目:
临床研究
出版日期:
2022-12-05

文章信息/Info

Title:
Effect of different controlled ovarian stimulation methods on clinical pregnancy rate of fresh cycle embryo transferafter IVF/ICSI for patients with EPs after TCRP
作者:
康卫卫; 黄剑磊; 马 媛; 贺 晓; 周 娟; 孙 丹; 王晓红
(空军军医大学唐都医院妇产科生殖医学中心,陕西 西安 710038)
Author(s):
KANG Weiwei; HUANG Jianlei; MA Yuan; HE Xiao; ZHOU Juan; SUN Dan; WANG Xiaohong
(Reproductive Medicine Center of Obstetrics and Gynecology,Tangdu Hospital,Air Force Medical University,Xi'an 710038,China)
关键词:
不孕症;  经宫腔镜子宫内膜息肉切除术;  促排卵方案;  体外受精;  卵细胞质内单精子注射;  临床妊娠率
Keywords:
Infertility;  Transcervical resection of polys;  Controlled ovarian stimulation methods;  In vitro fertilization;  Intra cytoplasmic sperm injection;  Clinical pregnancy rate
分类号:
R 271.14
DOI:
DOI:10.3969/j.issn.1000-7377.2022.12.009
文献标志码:
A
摘要:
目的:分析子宫内膜息肉(EPs)患者经宫腔镜子宫内膜息肉切除术(TCRP)后不同促排卵方案对体外受精(IVF)/卵细胞质内单精子注射(ICSI)助孕后新鲜周期胚胎移植临床妊娠率的影响。方法:选择TCRP术后行IVF/ICSI助孕并于新鲜周期行胚胎移植的EPs患者352例(366个周期),根据促不同排卵方案分为黄体期长方案组(198例,207个周期)和拮抗剂方案组(154例,159个周期)。比较两组一般资料和IVF/ICSI助孕指标。采用单因素及多因素回归分析方法探讨EPs患者TCRP术后不同促排卵方案对IVF/ICSI临床妊娠率的影响。结果:352例患者中,总体人绒毛膜促性腺激素(hCG)阳性率为56.28%,临床妊娠率为54.64%,早孕流产率为7.50%,异位妊娠率为1.00%。两组体重指数(BMI)、TCRP距胚胎移植时间间隔、息肉个数、胚胎移植周期次数、促性腺激素(Gn)用量、hCG日雌二醇(E<sup>2)水平、胚胎移植日子宫内膜形态比较,差异有统计学意义(均P<0.05)。单因素分析结果显示,年龄、BMI、息肉个数、息肉位置、受精方式为临床妊娠率的影响因素(均P<0.05)。在调整上述因素的影响后,多因素回归分析结果显示,不同促排卵方案的临床妊娠率比较差异无统计学意义(P>0.05)。结论:EPs患者TCRP术后不同促排卵方案对IVF/ICSI助孕后新鲜周期胚胎移植临床妊娠率无明显影响。
Abstract:
Objective:To analyze the effect of different controlled ovarian stimulation methods on the clinical pregnancy rate of fresh cycle embryo transfer after in vitro fertilization(IVF)/intra cytoplasmic sperm injection(ICSI)for patients with endometrial polyps(EPs)after hysteroscopic electroresection of endometrial polyps(TCRP).Methods:A total of 352 EPs patients(366 cycles)who underwent IVF/ICSI for pregnancy and embryo transfer in fresh cycle after TCRP were selected.According to different controlled ovarian stimulation methods,the patients were divided into luteal-phase long protocol group(198 cases,207 cycles)and antagonist protocol group(154 cases,159 cycles).The general data and IVF/ICSI indicators were compared between two groups.Univariate and multivariate regression analysis were used to investigate the effects of different controlled ovarian stimulation methods on the clinical pregnancy rate of fresh cycle embryo transfer after IVF/ICSI for EPs patients after TCRP.Results:Among the 352 patients,the overall hCG positive rate was 56.28%,the clinical pregnancy rate was 54.64%,the early pregnancy abortion rate was 7.50%,and the ectopic pregnancy rate was 1.00%.There were significant differences in BMI,the time interval between operation and embryo transfer,the number of polyps,the number of embryo transfer cycles,the dosage of Gn for ovulation induction,the E<sup>2 value on hCG day,and the morphology of intima on embryo transfer day between two groups(all P<0.05).The univariate analysis showed that age,BMI,number of polyps,polyp location and fertilization method had significant effects on clinical pregnancy rate(all P<0.05).After adjusting the influence of the above factors,the results of multivariate regression analysis showed that there was no significant difference in clinical pregnancy rate among different controlled ovarian stimulation methods(P>0.05).Conclusion:For EPs patients with infertility after TCRP,there was no significant effect of different controlled ovarian stimulation methods on the clinical pregnancy rate of fresh cycle embryo transfer after IVF/ICSI.

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备注/Memo

备注/Memo:
基金项目:北京健康促进会生殖医学中青年医生研究-基础研究项目(BJHPA-2022-SHZHYXZHQNYJ-JICH-009)
更新日期/Last Update: 2022-12-05