[1]高 宾,王春花,李雅琪,等.长链非编码RNA在口腔鳞状细胞癌及其微环境中的作用研究进展[J].陕西医学杂志,2022,51(11):1458-1461.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.033]
点击复制

长链非编码RNA在口腔鳞状细胞癌及其微环境中的作用研究进展
分享到:

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年11期
页码:
1458-1461
栏目:
综 述
出版日期:
2022-11-05

文章信息/Info

作者:
高 宾12王春花2李雅琪2高伊飞2齐广莹2
(1.桂林医学院附属医院病理科,广西 桂林 541000; 2.桂林医学院 广西肿瘤免疫与微环境调控重点实验室,广西 桂林 541000)
关键词:
口腔鳞状细胞癌 长链非编码RNA 肿瘤微环境 基因表达调控 细胞增殖 细胞凋亡
分类号:
R 739.8
DOI:
DOI:10.3969/j.issn.1000-7377.2022.11.033
文献标志码:
A
摘要:
口腔鳞状细胞癌作为口腔癌中最常见、最高发的肿瘤类型,在全世界公共卫生范围内是一个令人头疼的问题。关于口腔鳞状细胞癌的许多研究都已经完成或者正在进行,但近些年口腔鳞状细胞癌的生存率、治愈率及预后却并没有得到明显改善。长链非编码RNA(lncRNA)指的是一类长链RNA,但其本身并不编码蛋白质,对其研究仍在不断深入。lncRNA可以影响表观遗传、调控相关基因转录激活、进行基因修饰等,与人类疾病发生发展有密切联系。目前有关口腔鳞状细胞癌与lncRNA之间的研究也在不断进行当中,现对长链非编码RNA与口腔鳞状细胞癌及其微环境之间的作用进行综述。

参考文献/References:

[1] Rivera C.Essentials of oral cancer[J].Int J Clin Exp Pathol,2015,8(9):11884-11894.
[2] 王 楠,席 锦.口腔癌发病危险因素分析[J].陕西医学杂志,2021,50(4):417-420.
[3] Almangush A,Makitie AA,Triantafyllou A,et al.Staging and grading of oral squamous cell carcinoma:An update[J].Oral Oncol,2020,107:104799.
[4] Huang SH,Sullivan B.Oral cancer:Current role of radiotherapy and chemotherapy[J].Med Oral Patol Oral Cir Bucal,2013,18(2):233-240.
[5] Ganly I,Patel S,Shah J.Early stage squamous cell cancer of the oral tongue-clinicopathologic features affecting outcome[J].Cancer Am Cancer Soc,2012,118(1):101-111.
[6] Alves AM,Diel LF,Lamers ML.Macrophages and prognosis of oral squamous cell carcinoma:A systematic review[J].J Oral Pathol Med,2018,47(5):460-467.
[7] Zanoni DK,Montero PH,Migliacci JC,et al.Survival outcomes after treatment of cancer of the oral cavity(1985-2015)[J].Oral Oncol,2019,90:115-121.
[8] Irfan M,Delgado R,Frias-Lopez J.The oral microbiome and cancer[J].Front Immunol,2020,11:591088.
[9] Sun Z,Yang S,Zhou Q,et al.Emerging role of exosome-derived long non-coding rnas in tumor microenvironment[J].Mol Cancer,2018,17(1):82-88.
[10] Wang KC,Chang HY.Molecular mechanisms of long noncoding rnas[J].Mol Cell,2011,43(6):904-914.
[11] Yang L,Froberg JE,Lee JT.Long noncoding RNAs:Fresh perspectives into the RNA world[J].Trends Biochem Sci,2014,39(1):35-43.
[12] Zhang L,Meng X,Zhu XW,et al.Long non-coding RNAs in oral squamous cell carcinoma:Biologic function,mechanisms and clinical implications[J].Mol Cancer,2019,18(1):102-108.
[13] Gomes CC,Sousa SF,Calin GA,et al.The emerging role of long noncoding RNAs in oral cancer[J].Oral Surg Oral Med Oral Pathol Oral Radiol,2017,123(2):235-241.
[14] Sasahira T,Kirita T.Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma[J].Int J Mol Sci,2018,19(8):346-422.
[15] Miller KD,Nogueira L,Mariotto AB,et al.Cancer treatment and survivorship statistics,2019[J].CA Cancer J Clin,2019,69(5):363-385.
[16] Bugshan A,Farooq I.Oral squamous cell carcinoma:Metastasis,potentially associated malignant disorders,etiology and recent advancements in diagnosis[J].F1000 Res,2020,9:229-237.
[17] 施 健,胡千慧,张雪杰.口腔鳞癌组织长链非编码RNA LINC01605表达与临床病理特征关系研究[J].陕西医学杂志,2022,51(5):617-620.
[18] Li J,Xu X,Zhang D,et al.lncRNA lhfpl3-as1 promotes oral squamous cell carcinoma growth and cisplatin resistance through targeting miR-362-5p/chsy1 pathway[J].Onco Targets Ther,2021,14:2293-2300.
[19] Wu K,Jiang Y,Zhou W,et al.Long noncoding RNA rc3h2 facilitates cell proliferation and invasion by targeting microRNA-101-3p/ezh2 axis in oscc[J].Mol Ther Nucleic Acids,2020,20:97-110.
[20] Fu SW,Zhang Y,Li S,et al.lncRNA ttn-as1 promotes the progression of oral squamous cell carcinoma via miR-411-3p/nfat5 axis[J].Cancer Cell Int,2020,20:415.
[21] Liu S,Liu LH,Hu WW,et al.Long noncoding RNA tug1 regulates the development of oral squamous cell carcinoma through sponging miR-524-5p to mediate dlx1 expression as a competitive endogenous RNA[J].J Cell Physiol,2019,234(11):20206-20216.
[22] Ai Y,Wei H,Wu S,et al.Exosomal lncRNA lbx1-as1 derived from rbpj overexpressed-macrophages inhibits oral squamous cell carcinoma progress via miR-182-5p/foxo3[J].Front Oncol,2021,11:605884.
[23] Zhuang Z,Huang J,Wang W,et al.Down-regulation of long non-coding RNA tincr induces cell dedifferentiation and predicts progression in oral squamous cell carcinoma[J].Front Oncol,2020,10:624752.
[24] Wu J,Li Y,Liu J,et al.Down-regulation of lncRNA hcg11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p[J].J Gene Med,2021,23(3):3293-3299.
[25] Lu T,Liu H,You G.Long non-coding RNA c5orf66-as1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis[J].Int J Mol Med,2018,42(6):3291-3299.
[26] Tan J,Xiang L,Xu G.lncRNA meg3 suppresses migration and promotes apoptosis by sponging miR-548d-3p to modulate jak-stat pathway in oral squamous cell carcinoma[J].Iubmb Life,2019,71(7):882-890.
[27] Lu TX,Rothenberg ME.microRNA[J].J Allergy Clin Immunol,2018,141(4):1202-1207.
[28] Murugan AK,Munirajan AK,Alzahrani AS.microRNA:Modulators of the ras oncogenes in oral cancer[J].J Cell Physiol,2016,231(7):1424-1431.
[29] Ganju A,Khan S,Hafeez BB,et al.microRNA nanotherapeutics for cancer[J].Drug Discov Today,2017,22(2):424-432.
[30] Du Y,Yang H,Li Y,et al.Long non-coding RNA linc01137 contributes to oral squamous cell carcinoma development and is negatively regulated by miR-22-3p[J].Cell Oncol(Dordr),2021,44(3):595-609.
[31] Yang J,Shi X,Yang M,et al.Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncrna h19/miR-675-5p/pfkfb3 signaling pathway[J].Int J Oral Sci,2021,13(1):12.
[32] Xiao Z,Li J,Jin Q,et al.Long non-coding RNA oip5-as1 contributes to cisplatin resistance of oral squamous cell carcinoma through the miR-27b-3p/trim14 axis[J].Exp Ther Med,2021,21(4):408.
[33] Zhang D,Song Y,Li D,et al.Cancer-associated fibroblasts promote tumor progression by lncrna-mediated runx2/gdf10 signaling in oral squamous cell carcinoma[J].Mol Oncol,2022,16(3):780-794.
[34] Wang Q,Han J,Xu P,et al.Silencing of lncRNA snhg16 downregulates cyclin d1(ccnd1)to abrogate malignant phenotypes in oral squamous cell carcinoma(oscc)through upregulating miR-17-5p[J].Cancer Manag Res,2021,13:1831-1841.
[35] Zhang N,Zeng L,Wang S,et al.lncRNA fer1l4 promotes oral squamous cell carcinoma progression via targeting miR-133a-5p/prx1 axis[J].Onco Targets Ther,2021,14:795-806.
[36] Jia H,Wang X,Sun Z.Screening and validation of plasma long non-coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma[J].Oncol Lett,2021,21(2):172.
[37] Chen S,Yang M,Wang C,et al.Forkhead box d1 promotes emt and chemoresistance by upregulating lncRNA cytor in oral squamous cell carcinoma[J].Cancer Lett,2021,503:43-53.
[38] Quail DF,Joyce JA.Microenvironmental regulation of tumor progression and metastasis[J].Nat Med,2013,19(11):1423-1437.
[39] Dutta A,Roy A,Chatterjee S.Long noncoding RNAs in cancer immunity:A new avenue in drug discovery[J].Drug Discov Today,2021,26(1):264-272.
[40] Tang J,Fang X,Chen J,et al.Long non-coding RNA(lncRNA)in oral squamous cell carcinoma:Biological function and clinical application[J].Cancers(Basel),2021,13(23):661-667.
[41] Wang M,Zhou L,Yu F,et al.The functional roles of exosomal long non-coding RNAs in cancer[J].Cell Mol Life Sci,2019,76(11):2059-2076.
[42] Ding L,Ren J,Zhang D,et al.A novel stromal lncRNA signature reprograms fibroblasts to promote the growth of oral squamous cell carcinoma via lncRNA-caf/interleukin-33[J].Carcinogenesis,2018,39(3):397-406.
[43] Ding L,Ren J,Zhang D,et al.The TLR3 agonist inhibit drug efflux and sequentially consolidates low-dose cisplatin-based chemoimmunotherapy while reducing side effects[J].Mol Cancer Ther,2017,16(6):1068-1079.
[44] Yao Y,Chen S,Lu N,et al.lncRNA jpx overexpressed in oral squamous cell carcinoma drives malignancy via miR-944/cdh2 axis[J].Oral Dis,2021,27(4):924-933.
[45] Yu L,Huo L,Shao X,et al.lncRNA snhg5 promotes cell proliferation,migration and invasion in oral squamous cell carcinoma by sponging miR-655-3p/fzd4 axis[J].Oncol Lett,2020,20(6):310-319.
[46] Huang G,He X,Wei XL.lncRNA neat1 promotes cell proliferation and invasion by regulating miR365/rgs20 in oral squamous cell carcinoma[J].Oncol Rep,2018,39(4):1948-1956.
[47] Huang W,Zhou R,Mao L,et al.Esophageal cancer related gene-4 inhibits the migration and proliferation of oral squamous cell carcinoma through bc200 lncRNA/mmp-9 and -13 signaling pathway[J].Cell Signal,2019,62:109327.
[48] Jiang Q,Xue D,Shi F,et al.Prognostic significance of an autophagy-related long non-coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma[J].Oncol Lett,2021,21(1):29.

相似文献/References:

[1]易亭伍,梁 睿,宿向东.长链非编码RNA SNHG15通过miR-141-3p /KLF9机制调控鼻咽癌细胞增殖的实验研究[J].陕西医学杂志,2021,50(1):10.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.003]
 YI Tingwu,LIANG Rui,SU Xiangdong.Study on long chain non-coding RNA SNHG15 regulating the proliferation of nasopharyngeal carcinoma cells through miR-141-3p/KLF9[J].,2021,50(11):10.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.003]
[2]林兴伟,戚新春.干扰TRIAP1表达增强口腔鳞状细胞癌细胞对顺铂敏感性实验研究[J].陕西医学杂志,2022,51(2):131.[doi:DOI:10.3969/j.issn.1000-7377.2022.02.001]
 LIN Xingwei,QI Xinchun.Interference with the expression of TRIAP1 enhances the sensitivity of oral squamous cell carcinoma cells to cisplatin[J].,2022,51(11):131.[doi:DOI:10.3969/j.issn.1000-7377.2022.02.001]
[3]李博文,张心宇,刘 洋,等.肺腺癌患者血清长链非编码RNA miR155HG表达及意义[J].陕西医学杂志,2022,51(4):492.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.026]
 LI Bowen,ZHANG Xinyu,LIU Yang,et al.Expression and significance of lncRNA miR155HG in serum of patients with lung adenocarcinoma[J].,2022,51(11):492.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.026]
[4]巩 娟,张 栋.血清长链非编码RNA 小核仁RNA宿主基因16和miR-147a在重症肺炎患者血清中的表达及临床意义[J].陕西医学杂志,2023,52(1):75.[doi:DOI:10.3969/j.issn.1000-7377.2023.01.017]
 GONG Juan,ZHANG Dong.Expression and clinical significance of serum lncRNA SNHG16 and miR-147a in patients with severe pneumonia[J].,2023,52(11):75.[doi:DOI:10.3969/j.issn.1000-7377.2023.01.017]
[5]刘彤崴,高丽利,蔡宏宇,等.长链非编码RNA牛磺酸上调基因1在糖尿病肾病中的表达及意义[J].陕西医学杂志,2023,52(3):340.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.022]
 LIU Tongwei,GAO Lili,CAI Hongyu,et al.Expression and significance of lncRNA TUG1 in diabetic nephropathy[J].,2023,52(11):340.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.022]
[6]刘 俊,曾 龙,高 云,等.长链非编码RNA YAF2-AS1通过调控微小RNA-141-3p表达抑制肝星状细胞活化实验研究[J].陕西医学杂志,2023,52(9):1120.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.002]
 LIU Jun,ZENG Long,GAO Yun,et al.Long-chain non-coding RNA YAF2-AS1 inhibits activation of hepatic stellate cells by regulating expression of microRNA-141-3p[J].,2023,52(11):1120.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.002]
[7]高晨峰,刘 斌,陈小凤,等.JS-K对口腔鳞状细胞癌H157和CAL-27细胞增殖与凋亡的影响及机制实验研究[J].陕西医学杂志,2023,52(12):1631.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.003]
 GAO Chenfeng,LIU Bin,CHEN Xiaofeng,et al.Effects and mechanism of JS-K on proliferation and apoptosis of oral squamous cell carcinoma H157 and CAL-27 cells[J].,2023,52(11):1631.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.003]
[8]布力布·吉力斯汉,赛福丁·柯尤木,刘春晖,等.长链非编码RNA核富集转录子1对胃癌SGC7901细胞迁移、侵袭、自噬的影响及机制研究[J].陕西医学杂志,2023,52(12):1749.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.027]
 JILISIHAN Bulibu,KEYOUMU Saifuding,LIU Chunhui,et al.Effects of lncRNA NEAT1 on migration,invasion and autophagy of gastric cancer SGC7901 cells and its mechanism[J].,2023,52(11):1749.[doi:DOI:10.3969/j.issn.1000-7377.2023.12.027]
[9]伍勇彬,黄 山,姚巧玲,等.长链非编码RNA RP11-497E19.1对胃癌细胞增殖和侵袭的影响及机制实验研究[J].陕西医学杂志,2024,(6):729.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.002]
 WU Yongbin,HUANG Shan,YAO Qiaoling,et al.Effect of long non-coding RNA RP11-497E19.1 on proliferation and invasion of gastric cancer cells and its mechanism[J].,2024,(11):729.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.002]
[10]濮忠建,杨 军,杨 帆,等.基于长链非编码RNA HOX转录反义RNA探讨次乌头原碱对人肝癌SK-Hep-1细胞自噬的影响实验研究[J].陕西医学杂志,2024,(6):754.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.007]
 PU Zhongjian,YANG Jun,YANG Fan,et al.Effect of protopine on autophagy in human liver cancer SK-Hep-1 cells based on lncRNA HOTAIR[J].,2024,(11):754.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.007]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(02020160023)
更新日期/Last Update: 2022-11-09