[1]代 佳,韩卫军,贺 林,等.术前血清磷酸甘油酸激酶1、髓样相关蛋白8/14水平与前列腺癌根治术患者预后和生存情况相关性研究[J].陕西医学杂志,2022,51(11):1389-1392,1411.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.016]
　DAI Jia,HAN Weijun,HE Lin,et al.Correlation between preoperative serum phosphoglycerate kinase 1,myeloid-associated protein 8/14 levels and prognosis and survival of patients undergoing radical prostatectomy[J].,2022,51(11):1389-1392,1411.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.016]
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术前血清磷酸甘油酸激酶1、髓样相关蛋白8/14水平与前列腺癌根治术患者预后和生存情况相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年11期
页码:
1389-1392,1411
栏目:
临床研究
出版日期:
2022-11-05

文章信息/Info

Title:
Correlation between preoperative serum phosphoglycerate kinase 1,myeloid-associated protein 8/14 levels and prognosis and survival of patients undergoing radical prostatectomy
作者:
代 佳1; 韩卫军2; 贺 林1; 慕玉东1; 高红变3
(1.陕西省肿瘤医院检验科,陕西 西安 710061; 2.宝鸡市中医医院外三科,陕西 宝鸡 721001; 3.陕西省肿瘤医院病理科,陕西 西安 710061)
Author(s):
DAI Jia; HAN Weijun; HE Lin; MU Yudong; GAO Hongbian
(Department of Laboratory Medicine,Shaanxi Cancer Hospital,Xi'an 710061,China)
关键词:
前列腺癌;  前列腺根治术;  磷酸甘油酸激酶1;  髓样相关蛋白8/14;  预后;  生存状态
Keywords:
Prostate cancer;  Radical prostatectomy;  Phosphoglycerate kinase 1;  Myeloid-related protein 8/14;  Prognosis;  Survival state
分类号:
R 737.25
DOI:
DOI:10.3969/j.issn.1000-7377.2022.11.016
文献标志码:
A
摘要:
目的:探讨术前血清磷酸甘油酸激酶1(PGK-1)、髓样相关蛋白8/14(MRP8/14)水平与前列腺癌根治术患者预后以及术后生存情况的相关性。方法:选择80例前列腺癌根治术患者以及同期健康体检的100例健康者作为研究对象,所有研究对象均检测空腹血清中PGK-1和MRP8/14水平,其中前列腺癌患者于术前和术后1个月时检测。分析血清PGK-1和MRP8/14水平与前列腺癌根治术患者预后和总生存期(OS)、无进展生存期(PFS)的相关性。结果:前列腺癌组术前血清PGK-1和MRP8/14水平均显著高于健康组,术后1个月时血清PGK-1和MRP8/14水平均显著低于术前(均P<0.05)。复发患者术前血清PGK-1和MRP8/14水平均显著高于未复发患者(均P<0.05)。Log-Rank检验发现,血清PGK-1和MRP8/14低水平前列腺癌根治术患者PFS显著长于高水平患者(均P<0.01),血清PGK-1和MRP8/14低水平前列腺癌根治术患者OS也显著长于高水平患者(均P<0.01)。结论:术前血清PGK-1和MRP8/14水平均可能作为评估前列腺癌根治术患者预后和生存期的重要指标,高水平患者通常手术治疗预后较差。
Abstract:
Objective:To investigate the correlation between preoperative serum phosphoglycerate kinase 1(PGK-1),myeloid-related protein 8/14(MRP8/14)levels and prognosis and postoperative survival of patients with prostate cancer after radical prostatectomy.Methods:A total of 80 patients who underwent radical prostatectomy and 100 healthy people who underwent physical examination in the same period were selected as the research objects.The levels of PGK-1 and MRP 8/14 in fasting serum were detected in all studies,including prostate cancer patients before and one month after operation.The correlation between serum PGK-1,MRP 8/14 levels and the prognosis,overall survive(OS),progress-free survive(PFS)of patients undergoing radical prostatectomy was analyzed.Results:The levels of serum PGK-1 and MRP8/14 in prostate cancer group were significantly higher than those in healthy group before operation,and the levels of serum PGK-1 and MRP8/14 one month after operation were significantly lower than those before operation(all P<0.05).The levels of serum PGK-1 and MRP8/14 in patients with recurrence were significantly higher than those in patients without recurrence(all P<0.05).Log-Rank test showed that PFS of radical prostatectomy patients with low-level PGK-1 and MRP8/14 was significantly longer than that of patients with high-level,and OS of radical prostatectomy patients with low-level PGK-1 and MRP 8/14 was also significantly longer than that of patients with high-level(all P<0.01).Conclusion:Preoperative serum PGK-1 and MRP8/14 may be important indicators to evaluate the prognosis and survival of patients undergoing radical prostatectomy.Patients with high levels usually have poor prognosis after surgical treatment.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2020SF-D48)
更新日期/Last Update: 2022-11-09