[1]宁利佳,任晓红.辅助性T细胞亚群、超敏C-反应蛋白和免疫球蛋白E对患儿哮喘急性发作合并呼吸道病毒感染的诊断价值[J].陕西医学杂志,2022,51(10):1267-1269,1273.[doi:DOI:10.3969/j.issn.1000-7377.2022.10.022]
　NING Lijia,REN Xiaohong.Diagnostic value of helper T cell subsets,hs-CRP and IgE in children with acute asthma attack and respiratory virus infection[J].,2022,51(10):1267-1269,1273.[doi:DOI:10.3969/j.issn.1000-7377.2022.10.022]
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辅助性T细胞亚群、超敏C-反应蛋白和免疫球蛋白E对患儿哮喘急性发作合并呼吸道病毒感染的诊断价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年10期
页码:
1267-1269,1273
栏目:
临床研究
出版日期:
2022-10-05

文章信息/Info

Title:
Diagnostic value of helper T cell subsets,hs-CRP and IgE in children with acute asthma attack and respiratory virus infection
作者:
宁利佳1; 任晓红2
(1.杨凌示范区医院儿科,陕西 杨凌 712100; 2.宝鸡市妇幼保健院儿童呼吸科,陕西 宝鸡 721000)
Author(s):
NING Lijia; REN Xiaohong
(Department of Pediatrics,Yangling Demonstration Zone Hospital,Yangling 712100,China)
关键词:
辅助性T细胞亚群;  超敏C-反应蛋白;  免疫球蛋白E;  哮喘;  呼吸道病毒感染;  相关性
Keywords:
Helper T cell subset;  High-sensitivity C-reactive protein;  Immunoglobulin E;  Asthma;  Respiratory virus infection;  Correlation
分类号:
R 562.2
DOI:
DOI:10.3969/j.issn.1000-7377.2022.10.022
文献标志码:
A
摘要:
目的:探讨辅助性T细胞亚群、超敏C-反应蛋白(hs-CRP)和免疫球蛋白E(IgE)在哮喘急性发作合并呼吸道病毒感染患儿中的诊断及预后价值。方法:选择哮喘急性发作合并呼吸道病毒感染患儿72例作为合并组,同期选择单纯哮喘急性发作患儿72例作为对照组。检测合并组和对照组患儿CD4+辅助性T细胞、hs-CRP、IgE含量并进行相关性分析,随访合并组患儿的预后。结果:合并组的CD4+辅助性T细胞比例和IgE含量均显著低于对照组,血清hs-CRP含量显著高于对照组(均P<0.05)。在合并组与对照组患儿中,Pearson分析显示CD4+辅助性T细胞比例、hs-CRP、IgE含量与呼吸道病毒感染存在相关性(均P<0.05)。受试者工作特征(ROC)曲线显示CD4+辅助性T细胞比例、hs-CRP、IgE单项与联合检测预测复发的曲线下总面积为0.742、0.766、0.797、0.876。结论:CD4+辅助性T细胞、hs-CRP和IgE在哮喘急性发作合并呼吸道病毒感染患儿中呈现异常表达情况,与呼吸道病毒感染的发生显著相关。
Abstract:
Objective:To investigate the diagnostic and prognostic value of T helper cell subsets,high sensitivity C-reactive protein(hs-CRP)and immunoglobulin E(IgE)in children with acute asthma attack and respiratory virus infection.Methods:A total of 72 cases of children with acute asthma attack and respiratory virus infection were selected as the combined group,while 72 children with simple acute asthma attack were selected as the control group.The contents of CD4+ helper T cells,hs-CRP and IgE in two groups were detected and correlated,and the prognosis of the combined group was followed up.Results:The proportion of CD4+ helper T cells and IgE content in the combined group were significantly lower than those in the control group,and the serum hs-CRP content was significantly higher than that in the control group(all P<0.05).Pearson analysis showed that the proportion of CD4+ helper T cells,hs-CRP and IgE levels were correlated with respiratory virus infection(all P<0.05).ROC curve analysis showed that the total area under the curve of the proportion of CD4+ helper T cells,hs-CRP,IgE and combined detection for predicting recurrence was 0.742,0.766,0.797 and 0.876.Conclusion:CD4+ helper T cells,hs-CRP and IgE are abnormally expressed in children with acute asthma attack and respiratory virus infection,which is significantly related to the occurrence of respiratory virus infection.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生健康科研基金资助项目(2021E005)
更新日期/Last Update: 2022-10-07