[1]刘 锋,杨 涛,程 钰,等.人脑胶质瘤中硒蛋白P表达及临床意义[J].陕西医学杂志,2022,51(10):1179-1182,1195.[doi:DOI:10.3969/j.issn.1000-7377.2022.10.001]
　LIU Feng,YANG Tao,CHENG Yu,et al.Expression and clinical significance of selenoprotein P in human glioma[J].,2022,51(10):1179-1182,1195.[doi:DOI:10.3969/j.issn.1000-7377.2022.10.001]
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人脑胶质瘤中硒蛋白P表达及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年10期
页码:
1179-1182,1195
栏目:
基础研究
出版日期:
2022-10-05

文章信息/Info

Title:
Expression and clinical significance of selenoprotein P in human glioma
作者:
刘 锋1; 杨 涛1; 程 钰2; 李永来2; 赵子龙2; 李东波1; 张淳华1; 罗长稳1
(1.安康市中心医院神经外科,陕西 安康 725000; 2.安康市中心医院病理科,陕西 安康 725000)
Author(s):
LIU Feng; YANG Tao; CHENG Yu; LI Yonglai; ZHAO Zilong; LI Dongbo; ZHANG Chunhua; LUO Changwen
(Department of Neurosurgery,Ankang Central Hospital,Ankang 725000,China)
关键词:
硒蛋白P;  胶质瘤;  免疫组织化学;  胶质瘤病理级别;  相关性
Keywords:
Selenoprotein P;  Glioma;  Immunohistochemistry;  Pathological grade of glioma;  Correlation
分类号:
R 739.41
DOI:
DOI:10.3969/j.issn.1000-7377.2022.10.001
文献标志码:
A
摘要:
目的:探讨人脑胶质瘤中硒蛋白P的表达水平与肿瘤级别之间的相关性及临床意义。方法: 应用免疫组织化学法检测51例胶质瘤组织和9例正常脑组织中硒蛋白P的表达情况,分析硒蛋白P的表达差异性与病理级别之间的关系。结果:免疫组织化学染色显示硒蛋白P在正常脑组织和胶质瘤组织中均有表达,着色部位主要位于细胞质内。进一步分析发现硒蛋白P在正常脑组织和恶性程度相对较低的WHOⅠ级胶质瘤组织中表达均呈强阳性,组间比较无统计学差异(均P>0.05)。而硒蛋白P在恶性程度较高的WHO Ⅱ、Ⅲ、Ⅳ级胶质瘤中表达程度下降呈弱阳性,组间比较无统计学差异(均P>0.05),其表达强度与正常脑组织和WHO Ⅰ级胶质瘤比较有统计学差异(均P<0.05)。硒蛋白P的表达水平与年龄、性别及胶质瘤病理级别无相关性。结论:本研究发现硒蛋白P在恶性程度较高的WHO Ⅱ、Ⅲ、Ⅳ级胶质瘤组织中硒蛋白P表达程度下降,我们推测硒蛋白P在胶质瘤中可能发挥抗肿瘤作用。
Abstract:
Objective:To investigate the correlation between the expression of selenoprotein P and tumor grade in human glioma and its clinical significance.Methods:Immunohistochemistry was used to detect the expression of selenoprotein P in 51 glioma tissues and 9 normal brain tissues.T The relationship between the expression difference of selenoprotein P and pathological grade was analyzed.Results:The result of immunohistochemical staining showed that selenoprotein P was expressed in both normal brain tissues and glioma tissues,and the staining sites of selenoprotein P were mainly located in the cytoplasm.Further analysis revealed that the expression of selenoprotein P in normal brain tissues and the relatively low malignant WHO grade Ⅰ glioma tissues was strongly positive,and there was no statistical difference between the groups(all P>0.05).However,the expression of selenoprotein P in the highly malignant WHO grade Ⅱ,Ⅲ,and Ⅳ gliomas decreased and were weakly positive,and there was no statistical difference between groups(all P>0.05),and the expression intensity of selenoprotein P was significantly different from that in normal brain tissues and WHO grade Ⅰ gliomas(all P<0.05).The expression level of selenoprotein P was not significantly correlated with age,sex or grade of glioma.Conclusion:The expression of selenoprotein P was decreased in WHO grade Ⅱ,Ⅲ,and Ⅳ gliomas.We speculated that selenoprotein P may play an inhibitory role during the development of glioma.

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备注/Memo

备注/Memo:
基金项目:中国专项科技计划项目(2018FXZX04-14)
更新日期/Last Update: 2022-10-07