[1]马昱杭,韩昀屹,韩者艺.顶端钠依赖性胆酸转运体及其在相关疾病中的作用研究进展[J].陕西医学杂志,2022,51(9):1163-1166.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.028]
 MA Yuhang,HAN Yunyi,HAN Zheyi.Advances in apical sodium-dependent bile acid transporter and its role in related diseases[J].,2022,51(9):1163-1166.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.028]
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顶端钠依赖性胆酸转运体及其在相关疾病中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年9期
页码:
1163-1166
栏目:
综 述
出版日期:
2022-09-05

文章信息/Info

Title:
Advances in apical sodium-dependent bile acid transporter and its role in related diseases
作者:
马昱杭12韩昀屹12韩者艺2
(1.延安大学医学院,陕西 延安 716000; 2.空军军医大学,陕西 西安 710032)
Author(s):
MA YuhangHAN YunyiHAN Zheyi
(School of Medicine,Yan'an University,Yan'an 716000,China)
关键词:
根尖钠依赖胆汁酸转运体 胆汁酸循环 糖尿病 高胆固醇血症 非酒精性脂肪性肝病 原发性胆汁性胆管炎
Keywords:
Apical sodium-dependent bile acid transporter Bile acid cycle Diabetes mellitus Hypercholesterolemia Non-alcoholic fatty liver disease Primary biliary cholangitis
分类号:
R 57
DOI:
DOI:10.3969/j.issn.1000-7377.2022.09.028
文献标志码:
A
摘要:
胆汁酸(BA)的肠肝循环由肝脏和肠道中特定的信号分子控制,在机体代谢及消化系统中发挥重要作用。胆汁的分泌、转运和重吸收均受肠肝循环的调节。在此过程中,肝脏分泌的BA大部分通过顶端钠依赖性胆酸转运体(ASBT)被回肠末端肠上皮细胞吸收,然后转运至门静脉,对于维持机体胆汁酸循环稳态具有重要意义。ASBT的表达和功能异常可能导致一些与肠肝循环和代谢稳态紊乱相关的疾病,如糖尿病、高胆固醇血症、非酒精性脂肪性肝病(NAFLD)、原发性胆汁性胆管炎(PBC)等。现对ASBT及其在相关疾病中的作用研究进展进行综述。
Abstract:
The enterohepatic circulation of bile acid(BA)is controlled by specific signaling molecules in the liver and intestine,and plays an important role in metabolism and digestive system.Bile secretion,transport and reabsorption are regulated by enterohepatic circulation.During this process,most of the BA secreted by the liver is absorbed by the intestinal epithelial cells of the terminal ileum through the apical sodium-dependent bile acid transporter(ASBT)and then transported to the portal vein,which is important for maintaining the homeostasis of the body's bile acid cycle.Abnormal expression and function of ASBT may lead to some diseases related to disturbance of enterohepatic circulation and metabolic homeostasis,such as diabetes mellitus,hypercholesterolemia,nonalcoholic fatty liver disease(NAFLD),primary biliary cholangitis(PBC),and so on.This article reviews the research progress of ASBT and its role in related diseases.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81873562)
更新日期/Last Update: 2022-09-05