[1]张丽君,王 蓉,章 峰.左卡尼汀注射液对维持性血液透析患者微炎症状态、营养不良及氧化应激的影响[J].陕西医学杂志,2022,51(8):1004-1007.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.023]
　ZHANG Lijun,WANG Rong,ZHANG Feng.Effect of Levocanidine injection on microinflammatory state,malnutrition and oxidative stress in patients undergoing maintenance hemodialysis[J].,2022,51(8):1004-1007.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.023]
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左卡尼汀注射液对维持性血液透析患者微炎症状态、营养不良及氧化应激的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年8期
页码:
1004-1007
栏目:
药物与临床
出版日期:
2022-08-05

文章信息/Info

Title:
Effect of Levocanidine injection on microinflammatory state,malnutrition and oxidative stress in patients undergoing maintenance hemodialysis
作者:
张丽君; 王 蓉; 章 峰
(汉中市中心医院,陕西 汉中723000)
Author(s):
ZHANG Lijun; WANG Rong; ZHANG Feng
(Hanzhong Central Hospital,Hanzhong 723000,China)
关键词:
肾功能不全失代偿期;  维持性血液透析;  左卡尼汀注射液;  微炎症状态;  营养不良;  氧化应激
Keywords:
Decompensated stage of renal insufficiency;  Maintenance hemodialysis;  Levocanidine injection;  Microinflammatory state;  Malnutrition;  Oxidative stress
分类号:
R 625.9
DOI:
DOI:10.3969/j.issn.1000-7377.2022.08.023
文献标志码:
A
摘要:
目的:探讨左卡尼汀注射液对维持性血液透析患者机体微炎症状态、营养不良及氧化应激程度的影响,为肾功能不全失代偿期患者的透析治疗提供依据。方法:307例肾功能不全失代偿期维持性透析患者随机分为对照组153例、观察组154例,对照组接受常规治疗,观察组在常规治疗的基础上予以左卡尼汀注射液2 g,静脉注射,隔日1次,连续治疗3个月。比较两组患者治疗前后炎性因子、营养指标及氧化应激指标的变化。结果:两组治疗前血清炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、营养指标[白蛋白(Alb)、前白蛋白(PA)、血红蛋白(Hb)]水平以及氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)]水平比较均无统计学差异(均P>0.05); 治疗后两组炎性因子CRP、TNF-α及IL-6水平均降低,营养指标Alb、PA及Hb水平均升高,氧化应激指标GSH-Px、SOD水平均升高,MDA水平均降低,观察组各指标变化更为显著,与对照组治疗后各指标比较,差异均有统计学意义(均P<0.01)。结论:左卡尼汀在维持性血液透析治疗过程中能较好地改善患者微炎症状态、营养不良及机体的氧化应激状态,改善患者的生存质量。
Abstract:
Objective:To investigate the effect of Levocanidine injection on microinflammation,malnutrition and oxidative stress in patients undergoing maintenance hemodialysis,and to provide basis for dialysis treatment in patients with decompensated renal insufficiency.Methods:A total of 307 patients with decompensated renal insufficiency undergoing maintenance dialysis were randomly divided into control group(153 cases)and observation group(154 cases).The control group received conventional treatment,while the observation group received 2 g Levocanidine injection intravenously once every other day on the basis of conventional treatment for 3 months.The changes of inflammatory factors,nutritional indexes and oxidative stress indexes before and after treatment were compared between the two groups.Results:Before treatment,the levels of serum inflammatory factors [C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],nutritional indexes [albumin(Alb),prealbumin(PA),hemoglobin(Hb)]and oxidative stress indexes [glutathione peroxidase(GSH-Px),malondialdehyde(MDA),superoxide dismutase(SOD)] were not statistically different between the two groups(all P>0.05).After treatment,the levels of CRP,TNF-α and IL-6 in the two groups were decreased,the levels of Alb,PA and Hb were increased,the levels of GSH-Px and SOD were increased,and the level of MDA was decreased,and the changes of the above indexes in the observation group were more significant than those in the control group(all P<0.01).Conclusion:Levocanidine can improve the microinflammatory state,malnutrition and oxidative stress state of patients during maintenance hemodialysis treatment,and improve the quality of life of patients.

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备注/Memo

备注/Memo:
基金项目:陕西省科技计划项目(2014JQ4152)
更新日期/Last Update: 2022-08-04