[1]周 平,蔡 敏,袁 平,等.马来酸氟伏沙明联合经颅直流电刺激对首发强迫症患者认知功能、焦虑症状及血清5-羟色胺、脑源性神经营养因子水平的影响[J].陕西医学杂志,2022,51(8):990-994.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.020]
　ZHOU Ping,CAI Min,YUAN Ping,et al.Effects of fluvoxamine combined with transcranial direct current stimulation on cognitive function,anxiety symptoms,serum BDNF and 5-HT levels in patients with first-episode obsessive-compulsive disorder[J].,2022,51(8):990-994.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.020]
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马来酸氟伏沙明联合经颅直流电刺激对首发强迫症患者认知功能、焦虑症状及血清5-羟色胺、脑源性神经营养因子水平的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年8期
页码:
990-994
栏目:
药物与临床
出版日期:
2022-08-05

文章信息/Info

Title:
Effects of fluvoxamine combined with transcranial direct current stimulation on cognitive function,anxiety symptoms,serum BDNF and 5-HT levels in patients with first-episode obsessive-compulsive disorder
作者:
周 平1; 蔡 敏1; 袁 平2; 杨少婷2; 席 敏2
(1.空军军医大学西京医院,陕西 西安710032; 2.西北工业大学,陕西 西安 710072)
Author(s):
ZHOU Ping; CAI Min; YUAN Ping; YANG Shaoting; XI Min
(Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
关键词:
强迫症;  氟伏沙明;  经颅直流电刺激;  认知功能;  5-羟色胺;  脑源性神经营养因子
Keywords:
Obsessive compulsive disorder;  Fluvoxamine;  Transcranial direct current stimulation;  Cognitive function;  5-hydroxy tryptamine;  Brain-derived neurotrophic factor
分类号:
R 749.7
DOI:
DOI:10.3969/j.issn.1000-7377.2022.08.020
文献标志码:
A
摘要:
目的:探索经颅直流电刺激(tDCS)是否可以作为强迫症患者治疗的安全、有效的增效策略。方法:选择强迫症患者126例,随机等分入马来酸氟伏沙明联合tDCS治疗组和马来酸氟伏沙明联合假刺激治疗组。使用耶鲁布朗强迫量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)在基线、治疗后2、4、8周进行疗效评估。同时,采用威斯康星卡片测试(WCST)、韦氏记忆测试(WMT)比较两组患者治疗前后的认知功能变化; 使用治疗不良反应量表(TESS)评估患者出现的不良反应; 检测基线及治疗后血清5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平变化。结果:8周时,治疗组与对照组的有效率分别是83.33%和65.52%,两组比较差异有统计学意义(P<0.05); 治疗组在第4、8周时Y-BOCS、HAMA评分低于对照组(均P<0.05); 治疗组WCST各项评分以及WMT短期记忆、记忆商评分方面得分高于对照组(均P<0.05)。在治疗后第4、8周,两组TESS评分比较差异无统计学意义(均P>0.05)。治疗后,两组患者血清中5-HT及BDNF水平均增加,治疗组升高情况较对照组更显著(均P<0.05)。结论:对强迫症患者采用马来酸氟伏沙明联合tDCS治疗的方法疗效更为显著,可有效缓解强迫、焦虑症状并改善认知功能,也能调节血清5-HT及BDNF水平。
Abstract:
Objective: To explore whether transcranial direct current stimulation(tDCS)can be a safe and effective synergistic strategy for the treatment of patients with obsessive-compulsive disorder(OCD). Methods: A total of 126 patients with OCD were randomly divided into treatment group(fluvoxamine maleate combined with tDCS)and control group(fluvoxamine maleate combined with sham tDCS). The efficacy was assessed at baseline,2,4,and 8 weeks after treatment by using the Y-BOCS and HAMA. At the same time,the WCST and WMT were used to assess the cognitive function before and after treatment in the two groups. The TESS was used to evaluate the adverse reactions of the patients. The changes of serum serotonin(5-HT)and brain-derived neurotrophic factor(BDNF)levels were also evaluated before and after treatment. Results: At the end of 8 weeks-treatment,the effective rates of the treatment group and the control group were 83.33% and 65.52% respectively,and the difference was statistically significant(P<0.05). The Y-BOCS and HAMA scores of the treatment group were lower than those of the control group at weeks 4 and 8(all P<0.05); the WCST scores,WMT short-term memory and memory quotient scores in the treatment group were higher than those in the control group(all P<0.05). At the 4th and 8th week after treatment,there was no significant difference in TESS score between the two groups(P>0.05). After treatment,the serum levels of 5-HT and BDNF in both groups were increased,and the increase in the treatment group was more significant than that in the control group(all P<0.05). Conclusion: Fluvoxamine combined with tDCS is more effective for OCD patients,which can effectively relieve obsessive-compulsive and anxiety symptoms,and improve cognitive function,and can also regulate serum 5-HT and BDNF levels.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(81974215)
更新日期/Last Update: 2022-08-04