[1]耿海慧,曹爱华.卵巢癌患者多种血清肿瘤标志物表达水平及其对疾病的诊断价值研究[J].陕西医学杂志,2022,51(7):886-889.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.029]
　GENG Haihui,CAO Aihua.Expression levels of various serum tumor markers in ovarian cancer patients and their diagnostic value for the disease[J].,2022,51(7):886-889.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.029]
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卵巢癌患者多种血清肿瘤标志物表达水平及其对疾病的诊断价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年7期
页码:
886-889
栏目:
临床检验
出版日期:
2022-07-05

文章信息/Info

Title:
Expression levels of various serum tumor markers in ovarian cancer patients and their diagnostic value for the disease
作者:
耿海慧1; 曹爱华2
(1.北京市第六医院,北京100007; 2.北京华信医院,北京100016)
Author(s):
GENG Haihui; CAO Aihua
(Beijing No.6 Hospital,Beijing 100007,China)
关键词:
卵巢癌;  癌胚抗原;  糖类抗原199;  糖类抗原125;  甲胎蛋白;  良性
Keywords:
Ovarian cancer;  Carcinoembryonic antigen;  Carbohydrate antigen 199;  Carbohydrate antigen 125;  Alpha-fetoprotein;  Benign
分类号:
R 737.31
DOI:
DOI:10.3969/j.issn.1000-7377.2022.07.029
文献标志码:
A
摘要:
目的:探究癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)、甲胎蛋白(AFP)在卵巢癌患者中的表达水平及诊断价值。方法:选取92例卵巢良性疾病患者(卵巢良性疾病组),87例卵巢癌患者(卵巢癌组)及95例健康体检者(对照组)为研究对象。比较对照组、卵巢良性疾病组、卵巢癌组血清CEA、CA199、CA125、AFP水平,不同分期卵巢癌患者血清CEA、CA199、CA125、AFP水平,对照组、卵巢良性疾病组、卵巢癌组阳性率及CEA、CA199、CA125、AFP诊断卵巢癌的诊断效能。结果:卵巢癌组血清CEA、CA199、CA125、AFP水平均高于卵巢良性疾病组、对照组,且卵巢良性疾病组血清CA125水平高于对照组(均P<0.05); 卵巢癌Ⅲ期患者血清CEA、CA199、CA125、AFP水平均高于Ⅱ期、Ⅰ期患者,且Ⅱ期患者高于Ⅰ期患者(均P<0.05); 卵巢癌组CEA、CA199、CA125、AFP单项及联合检测阳性率高于卵巢良性疾病组、对照组,CEA、CA199、CA125、AFP四项联合检测卵巢癌的灵敏度、特异度、阳性预测值、阴性预测值、准确度分别为98.80%、75.00%、98.80%、75.00%、97.70%,均高于各项单独检测(均P<0.05)。结论: 卵巢癌患者血清CEA、CA199、CA125、AFP水平高于卵巢良性疾病患者,卵巢癌患者血清CEA、CA199、CA125、AFP水平与临床分期呈正相关,且CEA、CA199、CA125、AFP四项联合检测诊断效能高于单项检验。
Abstract:
Objective:To investigate the expression levels and diagnostic value of carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)and alpha-fetoprotein(AFP)in patients with ovarian cancer.Methods:A total of 92 patients with benign ovarian disease(benign ovarian disease group),87 ovarian cancer patients(ovarian cancer group)and 95 healthy patients were selected as the research objects.The serum levels of CEA,CA199,CA125 and AFP of three groups were compared.The serum levels of CEA,CA199,CA125 and AFP levels of ovarian cancer patients with different stages were compared.Positive rate of three groups and diagnostic efficacy of CEA,CA199,CA125,AFP in ovarian cancer were compared.Results:The serum levels of CEA,CA199,CA125 and AFP in ovarian cancer group were higher than those in benign ovarian disease group and the control group,and the serum level of CA125 in benign ovarian disease group was higher than that in control group(all P<0.05).The serum levels of CEA,CA199,CA125 and AFP in stage Ⅲ ovarian cancer patients were higher than those in stage Ⅰ and Ⅱ,and the levels in stage Ⅱ were higher than those in stage Ⅰ(all P<0.05).The positive rate of CEA,CA199,CA125 and AFP in single and combined tests in ovarian cancer group were higher than those in benign ovarian disease group and control group,and those in benign ovarian disease group were higher than those in control group(all P<0.05).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of CEA,CA199,CA125,and AFP in combined test for ovarian cancer were 98.80%,75.00%,and 98.80%,75.00% and 97.70%,which were higher than those in single test(all P<0.05).Conclusion:The serum levels of CEA,CA199,CA125,and AFP in ovarian cancer patients were higher than those in patients with benign ovarian diseases.The levels of serum CEA,CA199,CA125,and AFP in ovarian cancer patients were positively correlated with clinical stage,and the diagnostic efficiency of CEA,CA199,CA125 in combined test and AFP was higher than that in single test.

参考文献/References:

[1] 王 帅,程 锦.CT、阴道超声对卵巢良恶性肿瘤的诊断效能及与肿瘤标志物相关性分析[J].影像科学与光化学,2021,39(3):450-454.
[2] 刘亚娟,韩 瑜,郑 艳.卵巢癌患者血清甲胎蛋白、人绒毛膜促性腺激素、糖类抗原72-4水平预测淋巴结转移的受试者工作特征曲线分析[J].癌症进展,2021,19(3):294-297.
[3] 侯新霞,闫蓓蓓,刘 芸.血清HE4、AFP、CA125水平联合评价卵巢癌患者化疗近期疗效[J].热带医学杂志,2020,20(6):783-786.
[4] 韩 梅,马明杰,连 俊,等.血清AFP、CEA、CA199、CA125、HE4联合检测在卵巢癌诊断中的应用价值[J].河北医药,2022,44(1):76-78,82.
[5] 张善存,张江霞,王云龙.贝伐珠单抗联合TC方案治疗晚期卵巢癌患者血清AFP、CA125及远期预后的影响[J].实用癌症杂志,2021,36(6):1000-1003.
[6] Reed N,Millan D,Verheijen R,等.欧洲肿瘤内科协会对非上皮性卵巢癌的诊断、治疗和随访所制定的临床实践指南[J].国际妇产科学杂志,2011,38(4):339-342.
[7] 曹泽毅.妇科常见肿瘤诊治指南[M].北京:人民卫生出版社,2010:534-538.
[8] 陈艳梅,张春蕾,龚振英,等.卵巢癌患者四项血清肿瘤标志物水平的变化及意义[J].中国医药,2021,16(2):267-270.
[9] 邢华蕊,冯亚妮,黎小芳,等.血清肿瘤标志物水平与卵巢癌患者病理特征及预后的关系分析[J].河北医学,2020,26(8):1404-1408.
[10] 任小苗,赵 静.肿瘤减灭术后静脉腹腔联合化疗治疗晚期上皮性卵巢癌效果及对患者血清B7-H4蛋白、E-选择素水平的影响[J].陕西医学杂志,2021,50(10):1235-1238.
[11] 刘忠杰,赵 宁,宋永祯,等.血清肿瘤标志物CA153、CA125、CA72-4及FIB、IL-6水平用于卵巢癌检测的临床意义[J].海南医学院学报,2018,24(1):94-96,100.
[12] 杨 丽,孙孟雄,陈丽华.参芪扶正注射液联合TC方案化疗对晚期卵巢癌肿瘤标志物、肿瘤血管生成因子及免疫相关因子的影响[J].解放军医药杂志,2020,32(10):79-83.
[13] 王沈峰,金 迎,周禄荣,等.益气活血法治疗卵巢癌及对患者血清人附睾蛋白4、间皮素及肿瘤标记物的影响研究[J].陕西中医,2020,41(5):646-649.
[14] 靳桂红,王道军,马朝峰.氨磷汀联合化疗治疗卵巢癌的临床疗效及对患者血清肿瘤标志物、预后的影响[J].实用癌症杂志,2021,36(6):1004-1007.
[15] 郑 玲,张 坤,姚 田.贝伐单抗联合奥沙利铂对耐药卵巢癌患者生存期及血清miR-17-5p、人激肽释放酶10表达的影响[J].陕西医学杂志,2022,51(1):77-80.
[16] Guo B,Lian W,Liu S,et al.Comparison of iagnostic values between CA125 combined with CA199 and ultrasound combined with CT in ovarian cancer[J].Oncol Lett,2019,17(6):5523-5528.
[17] 陈 燕,郭玉格.多种肿瘤标志物联合检测对卵巢癌术后复发的早期诊断价值[J].医学临床研究,2021,38(8):1149-1151,1155.
[18] 李丹妍,刘 伟,钟 煊.卵巢恶性肿瘤患者腹腔积液中癌性血清标志物水平与化疗敏感相关性研究[J].实用癌症杂志,2020,35(8):1378-1381.
[19] 范艳佳,陈美红,颜林林.化学发光免疫法在肿瘤生物标志物检测中的应用价值[J].实用预防医学,2021,28(11):1397-1400.
[20] Asali A,Haj-Yehia N,Zehavi T,et al.High grade,advanced,serous ovarian cancer with low serum CA125 levels[J].J Obstet Gynaecol,2021,41(7):1107-1111.

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更新日期/Last Update: 2022-07-05