[1]何 芸,张卫卫,孔祥云.血清白细胞介素-6、肿瘤坏死因子-α、活性氧在食管癌术后并发心房颤动患者体内表达水平及检测意义[J].陕西医学杂志,2022,51(7):816-819.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.011]
　HE Yun,ZHANG Weiwei,KONG Xiangyun.Expression level and significance of serum IL-6,TNF-α and reactive oxygen species in patients with atrial fibrillation after esophageal cancer surgery[J].,2022,51(7):816-819.[doi:DOI:10.3969/j.issn.1000-7377.2022.07.011]
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血清白细胞介素-6、肿瘤坏死因子-α、活性氧在食管癌术后并发心房颤动患者体内表达水平及检测意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年7期
页码:
816-819
栏目:
临床研究
出版日期:
2022-07-05

文章信息/Info

Title:
Expression level and significance of serum IL-6,TNF-α and reactive oxygen species in patients with atrial fibrillation after esophageal cancer surgery
作者:
何 芸; 张卫卫; 孔祥云
(西安市第一医院,陕西 西安710002)
Author(s):
HE Yun; ZHANG Weiwei; KONG Xiangyun
(Xi'an No.1 Hospital,Xi'an 710002,China)
关键词:
食管癌;  并发症;  心房颤动;  白细胞介素-6;  肿瘤坏死因子-α;  活性氧
Keywords:
Esophageal cancer;  Complication;  Atrial fibrillation;  Interleukin-6;  Tumor necrosis factor-α;  Reactive oxygen species
分类号:
R 735.1
DOI:
DOI:10.3969/j.issn.1000-7377.2022.07.011
文献标志码:
A
摘要:
目的:探究血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、活性氧(ROS)在食管癌术后并发心房颤动患者体内表达水平及检测意义。方法: 收集接受术后治疗且并发术后房颤和无房颤发生的食管癌患者各50例分别为观察组和对照组。测定两组术前和术后血清IL-6、TNF-α和ROS水平,分析其表达水平与术后房颤发生的相关性。结果: 与治疗前比,两组治疗后血清IL-6、TNF-α和ROS水平均明显升高,且观察组明显高于对照组(均P<0.05)。二元回归分析显示,术后血清IL-6、TNF-α和ROS水平均是影响食管癌术后并发房颤的危险因素(均P<0.05); 受试者工作特征曲线(ROC)分析显示,术后次日血清IL-6、TNF-α和ROS水平均在预测食管癌术后并发房颤方面具有一定价值[AUC=0.837(95%CI:0.758～0.915)、0.873(95% CI:0.808～0.938)、0.906(95%CI:0.850～0.961)]。结论: 食管癌术后并发房颤者体内术后早期IL-6、TNF-α和ROS表达水平升高,临床可通过监测术后早期血清IL-6、TNF-α和ROS含量预测房颤发生风险,及时给予针对性干预。
Abstract:
Objective:To explore the expression level and significance of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and reactive oxygen species(ROS)in patients with atrial fibrillation(AF)after esophageal cancer surgery.Methods:Fifty cases of esophageal cancer patients with postoperative AF were collected as observation group,and another fifty cases of esophageal cancer patients without postoperative AF were collected as control group.The serum levels of IL-6,TNF-α and ROS were measured before and after surgery in the two groups,and the correlation between their expression levels and the occurrence of postoperative AF was analyzed.Results:The levels of serum IL-6,TNF-α and ROS in the two groups were significantly increased after treatment in comparison with those before treatment,and their levels in observation group were significantly higher than those in control group(all P<0.05).Binary regression analysis showed that serum IL-6,TNF-α and ROS levels were all risk factors for AF after esophageal cancer surgery(all P<0.05).Receiver operating characteristic(ROC)curve analysis showed that serum IL-6(AUC=0.837,95%CI:0.758 to 0.915),TNF-α(AUC=0.873,95%CI:0.808 to 0.938)and ROS(AUC=0.906,95%CI:0.850 to 0.961)levels at 1th day after esophageal cancer surgery were all valuable in predicting postoperative AF.Conclusion:The expression levels of IL-6,TNF-α and ROS in patients with postoperative AF are increased in the early postoperative period.Clinically,the risk of postoperative AF can be predicted by monitoring the serum levels of IL-6,TNF-α and ROS in the early postoperative period,and timely targeted intervention can be given.

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备注/Memo

备注/Memo:
基金项目:陕西省社会发展科技攻关项目(2015SF227); 西安市科技局科研项目(2021YB34)
更新日期/Last Update: 2022-07-05