[1]李 瑛,陈张琴.胃食管反流病对慢性阻塞性肺疾病患者生活质量及肺功能的影响[J].陕西医学杂志,2022,51(6):702-705.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.014]
　LI Ying,CHEN Zhangqin.Effect of gastroesophageal reflux disease on quality of life and pulmonary function in patients with chronic obstructive pulmonary disease[J].,2022,51(6):702-705.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.014]
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胃食管反流病对慢性阻塞性肺疾病患者生活质量及肺功能的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年6期
页码:
702-705
栏目:
临床研究
出版日期:
2022-06-05

文章信息/Info

Title:
Effect of gastroesophageal reflux disease on quality of life and pulmonary function in patients with chronic obstructive pulmonary disease
作者:
李 瑛; 陈张琴
(陕西省第二人民医院呼吸与危重症医学科,陕西 西安 710005)
Author(s):
LI Ying; CHEN Zhangqin
(Department of Respiratory and Critical Care Medicine,Second People's Hospital of Shaanxi Province,Xi'an 710005,China)
关键词:
慢性阻塞性肺疾病;  胃食管反流病;  胃食管反流问卷;  圣乔治呼吸问卷;  肺功能;  生活质量
Keywords:
Chronic obstructive pulmonary disease;  Gastroesophageal reflux disease;  GerdQ;  SGRQ;  Pulmonary function;  Quality of life
分类号:
R 563.9
DOI:
DOI:10.3969/j.issn.1000-7377.2022.06.014
文献标志码:
A
摘要:
目的:探讨胃食管反流病(GERD)对慢性阻塞性肺疾病(COPD)患者生活质量及肺功能的影响。方法:纳入COPD急性加重(AECOPD)患者120例为研究对象。所有患者均进行胃食管反流病问卷(GerdQ)调查,按照是否合并GERD为GERD组(57例,GerdQ评分≥8分)和非GERD组(63例,GerdQ评分<8分)。记录两组患者的一般资料。待患者进入稳定期后,对所有患者进行圣乔治呼吸问卷(SGRQ)调查和肺功能指标[第一秒用力呼气容积(FEV1)、FEV1与用力肺活量(FVC)比值以及第一秒用力呼气容积占预计值百分比(FEV1%pred)]检测。比较两组患者SGRQ问卷中症状、活动能力、疾病影响评分及总评分。比较两组患者FEV1、FEV1/FVC、FEV1%pred以及AECOPD发作次数。结果:GERD组SGRQ问卷中症状、活动能力、疾病影响单项评分及总评分高于非GERD组(均P<0.05)。GERD组FEV1、FEV1/FVC及FEV1%pred低于非GERD组(均P<0.05)。GERD组AECOPD发作次数多于非GERD组(P<0.05)。结论:与不合并GERD的COPD患者相比,合并GERD的COPD患者生活质量更低,肺功能更差,急性发作次数更多。
Abstract:
Objective:To investigate the effect of gastroesophageal reflux disease(GERD)on quality of life and pulmonary function in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of 120 patients with acute exacerbation of COPD(AECOPD)were included.All patients were investigated with GerdQ and were divided into GERD group(57 cases,GerdQ score ≥ 8)and non-GERD group(63 cases,GerdQ score < 8)according to whether GERD was combined.General data of both groups of patients were recorded.After the patients entered the stable phase,the SGRQ and pulmonary function indexes(FEV1,FEV1/FVC,and FEV1%pred)measurements were performed on all patients.The score of symptoms,activity ability,disease influence and total score in the SGRQ were compared between the two groups.FEV1,FEV1/FVC,FEV1%pred and the number of AECOPD episode were compared between the two groups.Results:The scores of symptom,activity ability,disease influence and total scores in the SGRQ of GERD group were higher than those of non-GERD group(all P<0.05).The FEV1,FEV1/FVC,and FEV1%pred in the GERD group were lower than those in the non-GERD group(all P<0.05).The number of AECOPD episode was higher in the GERD group than that in the non-GERD group(P<0.05).Conclusion:Compared with COPD patients without GERD,COPD patients with GERD had lower quality of life,worse pulmonary function,and more exacerbations.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生和计划生育委员会科研项目(2016D084)
更新日期/Last Update: 2022-06-06