[1]张 乐,陈 悦,陈姿伶,等.糖皮质激素与牙周健康关系研究进展[J].陕西医学杂志,2022,51(5):634-637,封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.028]
 ZHANG Le,CHEN Yue,CHEN Ziling,et al.Research progress on the relationship between glucocorticoids and periodontal health[J].,2022,51(5):634-637,封3.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.028]
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糖皮质激素与牙周健康关系研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年5期
页码:
634-637,封3
栏目:
综 述
出版日期:
2022-05-05

文章信息/Info

Title:
Research progress on the relationship between glucocorticoids and periodontal health
作者:
张 乐陈 悦陈姿伶钟梁秋月
(西安交通大学口腔医学院牙周病科,陕西 西安 710004)
Author(s):
ZHANG LeCHEN YueCHEN ZilingZHONG Liangqiuyue
(Department of Periodontology,School of Stomatology,Xi'an Jiaotong University,Xi'an 710004,China)
关键词:
糖皮质激素 糖皮质激素诱导的骨质疏松症 成骨细胞 牙周病 牙周组织 调控
Keywords:
Glucocorticoids Glucocorticoid-induced osteoporosis Osteoblast Periodontal disease Periodontal tissue Regulation
分类号:
R 781.4
DOI:
DOI:10.3969/j.issn.1000-7377.2022.05.028
文献标志码:
A
摘要:
糖皮质激素(GCs)是一种类固醇皮质激素,目前广泛应用于自身免疫性、炎症性和过敏性等疾病的治疗。但是长期应用GCs治疗的患者,会有出现一系列并发症的风险。现有研究从流行病学、组织化学、组织学等角度发现,GCs对牙周组织可能造成一定程度的破坏,影响牙周病的发生和发展以及与牙周组织相关的治疗(如种植、正畸等)。有学者针对该类问题提出了一些解决方案,从而为长期应用GCs治疗的患者更好地维护牙周健康提供了新的思路。现就GCs对牙周组织、牙周病和牙周相关治疗的影响,以及该类影响下必要的调控方式做一概述。
Abstract:
Glucocorticoids(GCs)are corticosteroids,which are currently widely used in the treatment of autoimmune,inflammatory and allergic diseases.However,patients who are treated with glucocorticoids for a long time are at risk of a series of complications.Existing studies have shown that from the perspectives of epidemiology,histochemistry and histology,GCs may cause a certain degree of damage to periodontal tissues,affecting the occurrence and development of periodontal disease and treatments related to periodontal tissues(such as implants,orthodontics,etc.).Some scholars have proposed some solutions to this type of problem,so as to provide new ideas for patients who have long-term application of GCs treatment to better maintain periodontal health.This article will give an overview of the effects of GCs on periodontal tissues,periodontal disease and periodontal-related treatments,and the necessary regulation methods under such influences.

参考文献/References:

[1] Vandewalle J,Luypaert A,De Bosscher K,et al.Therapeutic mechanisms of glucocorticoids[J].Trends in Endocrinology and Metabolism,2018,29(1):42-54.
[2] Burmester GR,Buttgereit F,Bernasconi C,等.糖皮质激素在低疾病活动度的类风湿关节炎患者中的应用:一项多中心、双盲、随机对照试验[J].中华医学杂志,2021,101(28):1-5.
[3] 杨 帆,沈俊逸,林彤彤,杨路昕,等.清瘟败毒饮联合糖皮质激素、环磷酰胺治疗系统性红斑狼疮气营热盛证临床研究[J].陕西中医,2020,41(9):1197-1199,1204.
[4] Orandi AB,Fotis L,Lai J,et al.Favorable outcomes with reduced steroid use in juvenile dermatomyositis[J].Pediatric Rheumatology Online Journal,2021,19(1):127.
[5] 王兰香,李卫红,周 瑾,等.消积豁痰汤加减联合糖皮质激素治疗老年支气管哮喘临床研究[J].陕西中医,2021,42(6):724-727.
[6] Compston J.Management of glucocorticoid-induced osteoporosis:What is new?[J].International Journal of Rheumatic Diseases,2019,22(9):1595-1597.
[7] 李生娇,曹志中,周中华.糖皮质激素对牙周炎发病作用的实验研究[J].临床口腔医学杂志,2002,23(4):253-255.
[8] Genco RJ,Borgnakke WS.Risk factors for periodontal disease[J].Periodontology,2000,62(1):59-94.
[9] Wang CJ,McCauley LK.Osteoporosis and periodontitis[J].Current Osteoporosis Reports,2016,14(6):284-291.
[10] 朱 洁,李建红,袁婷婷,等.绝经期女性骨质疏松与牙周重度附着丧失的相关性研究[J].中华口腔医学杂志,2020,55(3):6-10.
[11] Bouvard B,Gallois Y,Legrand E,et al.Glucocorticoids reduce alveolar and trabecular bone in mice[J].Joint Bone Spine,2013,80(1):77-81.
[12] Sousa LH,Moura EV,Queiroz AL,et al.Effects of glucocorticoid-induced osteoporosis on bone tissue of rats with experimental periodontitis[J].Archives of Oral Biology,2017,77:55-61.
[13] Piemontese M,Xiong J,Fujiwara Y,et al.Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice[J].American Journal of Physiology Endocrinology and Metabolism,2016,311(3):587-593.
[14] Glickman I,Stone IC,Chawla TN.The Effect of the systemic administration of cortisone upon the periodontium of white mice[J].Journal of Periodontology,2015,24(3):161-166.
[15] Garcia VG,Garcia VG,Fernandes LA,et al.Comparison between laser therapy and non-surgical therapy for periodontitis in rats treated with dexamethasone[J].Lasers in Medical Science,2010,25(2):197-206.
[16] Canalis E,Mazziotti G,Giustina A,et al.Glucocorticoid-induced osteoporosis:Pathophysiology and therapy[J].Osteoporosis International,2007,18(10):1319-1328.
[17] Sousa LH,Linhares EVM,Alexandre JT,et al.Effects of atorvastatin on periodontitis of rats subjected to glucocorticoid-induced osteoporosis[J].Journal of Periodontology,2016,87(10):1206-1216.
[18] 柏华民,吐苏娜依?吐拉克.糖皮质激素治疗风湿病引发骨质疏松56例临床分析[J].陕西医学杂志,2013,42(8):1034-1036.
[19] Walsh LJ,Wong CA,Oborne J,et al.Adverse effects of oral corticosteroids in relation to dose in patients with lung disease[J].Thorax,2001,56(4):279-284.
[20] Shen G,Ren H,Shang Q,et al.Autophagy as a target for glucocorticoid-induced osteoporosis therapy[J].Cellular and Molecular Life Sciences,2018,75(15):2683-2693.
[21] Kalia S,Melsen B,Verna C.Tissue reaction to orthodontic tooth movement in acute and chronic corticosteroid treatment[J].Orthodontics & Craniofacial Research,2004,7(1):26-34.
[22] Michelogiannakis D,Al-Shammery D,Rossouw PE,et al.Influence of corticosteroid therapy on orthodontic tooth movement:A narrative review of studies in animal-models[J].Orthodontics & Craniofacial Research,2018,21(4):216-224.
[23] Perinpanayagam H,Zaharias R,Stanford C,et al.Early cell adhesion events differ between osteoporotic and non-osteoporotic osteoblasts[J].J Orthop Res,2001,19(6):993-1000.
[24] Andreasen CM,Ding M,Andersen TL,et al.Effects of substitute coated with hyaluronic acid or poly-lactic acid on implant fixation:Experimental study in ovariectomized and glucocorticoid-treated sheep[J].Journal of Tissue Engineering and Regenerative Medicine,2018,12(2):1122-1130.
[25] 梁 爽,汪 鹏,高江红,等.四氟化钛对变形链球菌生长及产酸作用的初步研究[J].陕西医学杂志,2017,46(9):1165-1167.
[26] Lee M,Arikawa K,Nagahama F.Micromolar levels of sodium fluoride promote osteoblast differentiation through runx2 signaling[J].Biological Trace Element Research,2017,178(2):283-291.
[27] Bhawal UK,Lee H,Arikawa K,et al.Micromolar sodium fluoride mediates anti-osteoclastogenesis in porphyromonas gingivalis-induced alveolar bone loss[J].International Journal of Oral Science,2015,7(4):242-249.
[28] Vervaeke S,Collaert B,Vandeweghe S,et al.The effect of smoking on survival and bone loss of implants with a fluoride-modified surface:A 2-year retrospective analysis of 1106 implants placed in daily practice[J].Clinical Oral Implants Research,2012,23(6):758-766.
[29] Simon MJK,Beil FT,Riedel C,et al.Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure[J].Clinical Oral Investigations,2016,20(9):2361-2370.
[30] Isilay OA,Akca G,senel S.Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis[J].European Journal of Pharmaceutical Sciences,2018,124:208-216.
[31] Özdogan AI,Ilarslan YD,Kösemehmetoglu K,et al.In vivo evaluation of chitosan based local delivery systems for atorvastatin in treatment of periodontitis[J].International Journal of Pharmaceutics,2018,550(1-2):470-476.
[32] Petit C,Batool F,Stutz C,et al.Development of a thermosensitive statin loaded chitosan-based hydrogel promoting bone healing[J].International Journal of Pharmaceutics,2020,586:119534.
[33] Dalcico R,Menezes AMA,Deocleciano OB,et al.Protective mechanisms of simvastatin in experimental periodontal disease[J].Journal of Periodontology,2013,84(8):1145-1157.
[34] Araújo JRF,Souza TO,Moura LM,et al.Atorvastatin decreases bone loss,inflammation and oxidative stress in experimental periodontitis[J].PloS One,2013,8(10):75322.
[35] Dompe C,Moncrieff L,Matys J,et al.Photobiomodulation-underlying mechanism and clinical applications[J].Journal of Clinical Medicine,2020,9(6):1724.
[36] Migliario M,Pittarella P,Fanuli M,et al.Laser-induced osteoblast proliferation is mediated by ROS production[J].Lasers in Medical Science,2014,29(4):1463-1467.
[37] Agas D,Hanna R,Benedicenti S,et al.Photobiomodulation by near-infrared 980-nm wavelengths regulates pre-osteoblast proliferation and viability through the PI3K/Akt/Bcl-2 Pathway[J].International Journal of Molecular Sciences,2021,22(14):345-349.

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更新日期/Last Update: 2022-05-05