[1]金鑫燚,康鸣竹,赖正够,等.牙周基础治疗对2型糖尿病伴牙周炎患者龈沟液瘦素水平及临床牙周指标的影响[J].陕西医学杂志,2022,51(5):582-585.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.016]
　JIN Xinyi,KANG Mingzhu,LAI Zhenggou,et al.Effect of basic periodontal therapy on leptin level in gingival crevicular fluid and clinical periodontal indexes in patients with type 2 diabetes mellitus and periodontitis[J].,2022,51(5):582-585.[doi:DOI:10.3969/j.issn.1000-7377.2022.05.016]
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牙周基础治疗对2型糖尿病伴牙周炎患者龈沟液瘦素水平及临床牙周指标的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年5期
页码:
582-585
栏目:
临床研究
出版日期:
2022-05-05

文章信息/Info

Title:
Effect of basic periodontal therapy on leptin level in gingival crevicular fluid and clinical periodontal indexes in patients with type 2 diabetes mellitus and periodontitis
作者:
金鑫燚1; 康鸣竹1; 赖正够1; 刘 迪1; 杨芳楠1; 吴芷芸2
(1.锦州医科大学,辽宁 锦州 121000; 2.锦州医科大学附属第三医院,辽宁 锦州 121000)
Author(s):
JIN Xinyi; KANG Mingzhu; LAI Zhenggou; LIU Di; YANG Fangnan; WU Zhiyun
(Jinzhou Medical University,Jinzhou 121000,China)
关键词:
2 型糖尿病;  牙周炎;  瘦素;  牙周基础治疗;  牙周临床指标;  糖化血红蛋白
Keywords:
Type 2 diabetes mellitus;  Periodontitis;  Leptin;  Basic periodontal therapy;  Clinical periodontal indexes;  HbA1c
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2022.05.016
文献标志码:
A
摘要:
目的:探讨牙周基础治疗对2型糖尿病伴牙周炎患者龈沟液中瘦素水平及临床牙周指标的影响。方法:选取2型糖尿病伴牙周炎患者30例进行牙周基础治疗,记录所有患者治疗前及治疗后1个月牙周袋探诊深度(PD)、牙周附着水平(AL)、菌斑指数(PLI)及探诊出血(BOP),并用高效液相层析法检测患者糖化血红蛋白(HbA1c)变化,用酶联免疫吸附法(ELISA)检测龈沟液中瘦素水平变化。结果:与治疗前相比,牙周基础治疗1个月后,2型糖尿病伴牙周炎患者牙周临床指标(PD、AL、PLI、BOP)均降低,差异有统计学意义(均P<0.05)。治疗后血清HbA1c水平及龈沟液瘦素水平均降低,差异有统计学意义(均P<0.05)。治疗前龈沟液瘦素水平与PD、AL、PLI、BOP指标值均呈正相关(r=0.770、0.798、0.818、0.866,P<0.01)。结论:牙周基础治疗后,2型糖尿病伴牙周炎患者牙周临床指标、HbA1c及龈沟液中瘦素水平均下降。
Abstract:
Objective:To explore the effect of basic periodontal therapy on leptin(LEP)level in gingival crevicular fluid and clinical periodontal parameters in patients with type 2 diabetes mellitus and periodontitis.Methods:A total of 30 patients with type 2 diabetes mellitus and periodontitis were selected for basic periodontal therapy.The probing depth(PD),periodontal attachment level(AL),plaque index(PLI)and probing bleeding(BOP)of all subjects were recorded at baseline and 1 months after treatment.High performance liquid chromatography detection was used to determine the expression of the glycated hemoglobin(HbA1c)in plasma samples.LEP level in gingival crevicular fluid was measured by ELISA.Results:After one month of basic periodontal treatment,the periodontal clinical indexes(PD,AL,PLI,BOP)of patients with type 2 diabetes mellitus and periodontitis decreased in comparison with those before treatment(all P<0.05).After treatment,the level of serum HbA1c and the level of LEP in gingival crevicular fluid decreased(all P<0.05).The level of LEP in gingival crevicular fluid before treatment was positively correlated with PD,AL,PLI and BOP(r=0.770,0.798,0.818 and 0.866,all P<0.01).Conclusion:Periodontal clinical parameters,HbA1c and LEP in gingival crevicular fluid of type 2 diabetic patients with periodontitis decreased after basic periodontal treatment.

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备注/Memo

备注/Memo:
基金项目:辽宁省自然科学基金资助项目(2013022024); 辽宁省教育厅基金资助面上项目(LJKZ0795); 辽宁省大学生创新创业课题(20201016021)
更新日期/Last Update: 2022-05-05