[1]刘逢逢,马贺骥.胃癌CT纹理分析在TNM分期中的应用研究[J].陕西医学杂志,2022,51(4):474-477.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.021]
　LIU Fengfeng,MA Heji.Application of CT texture analysis in TNM staging of gastric cancer[J].,2022,51(4):474-477.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.021]
点击复制

胃癌CT纹理分析在TNM分期中的应用研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年4期
页码:
474-477
栏目:
临床研究
出版日期:
2022-04-05

文章信息/Info

Title:
Application of CT texture analysis in TNM staging of gastric cancer
作者:
刘逢逢; 马贺骥
(锦州医科大学附属第一医院,辽宁 锦州 121000)
Author(s):
LIU Fengfeng; MA Heji
(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China)
关键词:
胃癌;  计算机断层扫描;  纹理分析;  TNM分期;  动脉期;  静脉期
Keywords:
Gastric cancer;  Computed tomography;  Texture analysis;  TNM staging;  Arterial phase;  Venous phase
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2022.04.021
文献标志码:
A
摘要:
目的:探讨并分析胃癌计算机断层扫描(CT)纹理分析在TNM分期中的应用。方法:回顾性分析确诊的153例胃腺癌患者,所有患者术前均行CT检查,利用纹理分析软件测量提取动脉期和静脉期CT图像的纹理参数,并比较动脉期和静脉期中TNM分期的平均CT值、最大频率、偏度值、峰度值及熵值变化,采用Pearson相关性分析T分期与CT纹理参数的关系; 采用受试者工作曲线(ROC)评价CT纹理参数对N分期的评估效能。结果:动脉期中T1组的最大频率显著低于T2-4组,偏度值高于T2-4组(均P<0.05); 静脉期中T1组的最大频率及峰度值均显著低于T2-4组,偏度值高于T2-4组(均P<0.05); Pearson相关性分析显示,T分期与动脉期最大频率、静脉期最大频率及峰度值呈正相关关系,与动脉期偏度值、静脉期偏度值呈负相关关系(均P<0.05); 动脉期中N0组的最大频率显著低于N1-3组,偏度值及峰度值高于N1-3组(均P<0.05); 静脉期中N0组的最大频率及峰度值均显著低于N1-3组,偏度值高于N1-3组(均P<0.05),动脉期最大频率、偏度值及峰度值评估N分期的AUC分别为0.737、0.726及0.718; 静脉期最大频率、偏度值及峰度值的AUC分别为0.735、0.711及0.720(均P<0.05)。结论:CT纹理分析可有效评估胃癌TNM分期,指导临床治疗。
Abstract:
Objective:To explore and analyze the application of computed tomography(CT)texture analysis in TNM staging of gastric cancer.Methods:A retrospective analysis was performed on the 153 patients with gastric adenocarcinoma.All patients underwent CT examination before surgery.The texture parameters of CT images in the arterial and venous phases were measured by texture analysis software.The changes in mean CT value,the maximum frequency,skewness,kurtosis and entropy of TNM staging in arterial and venous stages were compared.The relationship between T staging and CT texture parameters was analyzed by Pearson correlation analysis.The evaluation efficiency of CT texture parameters for N staging was assessed by receiver operating characteristic(ROC)curve.Results:In arterial phase,the maximum frequency in T1 group was significantly lower than that in T2-4 group,while skewness value was greater than that in T2-4 group(all P<0.05).In venous phase,the maximum frequency and kurtosis in T1 group were significantly lower than those in T2-4 group,while skewness value was greater than that in T2-4 group(all P<0.05).Pearson correlation analysis showed that T staging was positively correlated with the maximum frequency in arterial phase and venous phase,kurtosis in venous phase,while negatively correlated with skewness values in arterial and venous phases(all P<0.05).In arterial phase,the maximum frequency in N0 group was significantly lower than that in N1-3 group,while skewness and kurtosis values were greater than those in N1-3 group(all P<0.05).In venous phase,the maximum frequency and kurtosis in N0 group were significantly lower than those in N1-3 group,while skewness value was greater than that in N1-3 group(all P<0.05).AUC values of the maximum frequency,skewness and kurtosis in arterial phase for assessing N staging were 0.737,0.726 and 0.718 respectively,and AUC values of the maximum frequency,skewness and kurtosis in venous phase for assessing N staging were 0.735,0.711 and 0.720,respectively(all P<0.05).Conclusion:CT texture analysis can effectively assess TNM staging of gastric cancer and guide clinical treatment.

参考文献/References:

[1] Waldum HL,Fossmark R.Types of gastric carcinomas[J].Int J Mol Sci,2018,19(12):4109.
[2] 余 明,王 博,张亚飞,等.癌前病变及胃癌与幽门螺杆菌感染的关系探讨[J].陕西医学杂志,2018,47(11):1424-1426.
[3] Sutton P,Boag JM.Status of vaccine research and development for helicobacter pylori[J].Vaccine,2019,37(50):7295-7299.
[4] Oh DY,Bang YJ.Adjuvant and neoadjuvant therapy for gastric cancer[J].Curr Treat Options Oncol,2019,14(3):311-320.
[5] Yan C,Zhu ZG,Yan M,et al.Value of multidetector-row computed tomography in the preoperative T and N staging of gastric carcinoma:A large-scale Chinese study[J].J Surg Oncol,2019,100(3):205-214.
[6] Ng F,Ganeshan B,Kozarski R,et al.Assessment of primary colorectal cancer heterogeneity by using whole-tumour texture analysis:Contrast-enhanced CT texture as a biomarker of 5-year survival[J].Radiology,2020,266(1):177-184.
[7] Bayanati H,ETR,Souza CA,et al.Quantitative CT texture and shape analysis:Can it differentiate benign and malignant mediastinal lymph nodes in patients with primary lung cancer?[J].Eur Radiol,2020,25(2):480-487.
[8] 中华医学会消化内镜学分会,中国抗癌协会肿瘤内镜专业委员会.中国早期胃癌筛查及内镜诊治共识意见(2014年,长沙)[J].中华消化杂志,2014,34(7):361-377.
[9] Kim HJ,Kim AY,Oh ST,et al.Gastric cancer staging at multi-detector row CT gastrography:Comparison of transverse and volumetric CT scanning[J].Radiology,2020,236(3):879-885.
[10] Gullo I,Grillo F,Mastracci L,et al.Precancerous lesions of the stomach,gastric cancer and hereditary gastric cancer syndromes[J].Pathologica,2020,112(3):166-185.
[11] Smyth EC,Nilsson M,Grabsch HI,et al.Gastric cancer[J].Lancet,2020,396(10251):635-648.
[12] Deng Y,Soule E,Samuel A,et al.CT texture analysis in the differentiation of major renal cell carcinoma subtypes and correlation with Fuhrman grade[J].Eur Radiol,2019,29(12):6922-6929.
[13] Liu S,Shi H,Ji C,et al.CT textural analysis of gastric cancer:Correlations with immunohistochemical biomarkers[J].Sci Rep,2018,8(1):11844.
[14] 张汝森,李 伟,李 雯,等.基于99m Tc-MDP高摄取的骨转移瘤的SPECT色阶分布特点分析及与骨外伤性病灶的对比[J].广东医学,2018,39(23):79-83.
[15] Chen XH,Ren K,Liang P,et al.Spectral computed tomography in advanced gastric cancer:Can iodine concentration non-invasively assess angiogenesis?[J].World J Gastroenterol,2017,23(9):1666-1675.
[16] Liu JJ,Liu W,Jin ZY,et al.Improved visualization of gastric cancer and increased diagnostic performance in lesion depiction and depth identification using monoenergetic reconstructions from a novel dual-layer spectral detector CT[J].Acad Radiol,2020,27(6):e140-e147.
[17] 唐彩银,张 继,田为中.CT纹理分析在量化食管鳞状细胞癌T、N分期方面的评价[J].中国医疗设备,2018,33(11):4-5.
[18] Giganti F,Antunes S,Salerno A,et al.Gastric cancer:Texture analysis from multidetector computed tomography as a potential preoperative prognostic biomarker[J].Eur Radiol,2017,27(5):1831-1839.

相似文献/References:

[1]侯洁心 ,郭萍△.免疫组化标志物Her2和肿瘤标志物在胃癌诊断中的价值分析*[J].陕西医学杂志,2019,(1):121.
　HOU Jiexin,GUO Ping..The value of immunohistochemical marker Her2 andtumor markers in the diagnosis of gastric cancer[J].,2019,(4):121.
[2]唐亚荣.循环热灌注化疗联合替吉奥及热疗治疗老年胃癌癌性腹水临床研究*[J].陕西医学杂志,2019,(4):435.
　TANG Yarong..Clinical effect analysis of combined therapy with tiago and hyperthermia in the treatment of malignant ascites in elderly patients with gastric cancer[J].,2019,(4):435.
[3]刘国庆,闫 龙△,高 任.1.5T磁共振扩散加权成像在胃癌淋巴结转移诊断中的应用价值*[J].陕西医学杂志,2019,(4):456.
　LIU Guoqing,YAN Long,GAO Ren..1.5T magnetic resonance diffusion weighted imaging in the diagnosis of lymph node metastasis of gastric cancer[J].,2019,(4):456.
[4]胡乃军,王海龙.胃腺癌组织中MMP11、MMP12和VEGFD的表达及临床意义[J].陕西医学杂志,2019,(5):554.
[5]米志宽,赵菊梅.抑癌基因甲基化与胃癌关系研究进展*[J].陕西医学杂志,2019,(5):679.
　MI Zhikuan,ZHAO Jumei..Research progress of relationships between tumor suppressor gene methylation and gastric cancer[J].,2019,(4):679.
[6]石颖鹏,王敏娟,李程亮.肠化生相关分子与胃癌的发生和进展研究概况[J].陕西医学杂志,2019,(7):958.
　SHI Yingpeng,WANG Minjuan,LI Chengliang,et al.Intestinal metaplasia-related molecules and the occurrence and progress of gastric cancer[J].,2019,(4):958.
[7]郭小艳,于桂萍.抗幽门螺杆菌疗法联合新辅助化疗对胃癌术后疗效及患者血清VEGF、bFGF的影响[J].陕西医学杂志,2019,(8):1010.
　GUO Xiaoyan,YU Guiping..Effect of anti-Helicobacter pylori therapy combined with neoadjuvant chemotherapy on serum VEGF and bFGF in postoperative patients with gastric cancer[J].,2019,(4):1010.
[8]柯东平,毛俊倩,郭甲民,等.SCNN1B与胃癌细胞上皮间质转化相关性实验研究*[J].陕西医学杂志,2019,(9):1115.
　KE Dongping,MAO Junqian,GUO Jiamin,et al.Research on the correlation between SCNN1B and〖JZ〗 epithelialmesenchymal transformation in gastric cancer cells[J].,2019,(4):1115.
[9]王小林,马任远,张 哲.腹腔镜手术治疗老年进展期胃癌50例临床疗效分析[J].陕西医学杂志,2019,(10):1360.
[10]刘维帅,郭晓宁,杨 洋,等.胃癌病理类型及临床预后与血清miR-133a和DKK-1相关性分析[J].陕西医学杂志,2020,49(6):751.[doi:DOI:10.3969/j.issn.10007377.2020.06.028]
　LIU Weishuai,GUO Xiaoning,YANG Yang,et al.Correlation of pathological types and clinical prognosis of gastric cancer with serum miR-133a and DKK-1[J].,2020,49(4):751.[doi:DOI:10.3969/j.issn.10007377.2020.06.028]

更新日期/Last Update: 2022-04-07