[1]谢家诚,马晓聪,罗伟生.长链非编码RNA在丙型肝炎病毒感染中的作用研究进展[J].陕西医学杂志,2022,51(3):378-381.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.027]
 XIE Jiacheng,MA Xiaocong,LUO Weisheng.Research progress on the role of long non-coding RNA in hepatitis C virus infection[J].,2022,51(3):378-381.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.027]
点击复制

长链非编码RNA在丙型肝炎病毒感染中的作用研究进展
分享到:

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年3期
页码:
378-381
栏目:
综 述
出版日期:
2022-03-05

文章信息/Info

Title:
Research progress on the role of long non-coding RNA in hepatitis C virus infection
作者:
谢家诚1马晓聪1罗伟生2
(1.广西中医药大学,广西 南宁 530001; 2.广西中医药大学附属瑞康医院,广西 南宁 530011)
Author(s):
XIE JiachengMA XiaocongLUO Weisheng
(Guangxi University of Chinese Medicine,Nanning 530001,China)
关键词:
长链非编码RNA 丙型肝炎病毒 病毒细胞生命周期 干扰素 干扰素刺激基因
Keywords:
Long non-coding RNA Hepatitis C virus Viral cell life cycle Interferon Interferon-stimulated gene
分类号:
R 512.63
DOI:
DOI:10.3969/j.issn.1000-7377.2022.03.027
文献标志码:
A
摘要:
长链非编码RNA(lncRNA)是一类含有200多个碱基的RNA分子,不具备编码蛋白质的功能。大多数lncRNA在丙型肝炎病毒(HCV)感染细胞中被解除调控,具有增强或阻断抗病毒反应的功能,从而影响HCV复制。现从影响病毒细胞生命周期、调控干扰素(IFN)应答、调控干扰素刺激基因(ISG)表达和转录几方面对HCV感染后lncRNA调节的作用进展进行阐述。
Abstract:
Long non-coding RNAs(lncRNA)are a class of RNA molecules containing more than 200 bases and do not have the function of encoding proteins.Most lncRNAs are deregulated in hepatitis C virus(HCV)-infected cells and have the function of enhancing or blocking antiviral responses,thus affecting HCV replication.In this paper,we discuss the role of lncRNA regulation after HCV infection in terms of affecting the viral cell life cycle,regulating interferon(IFN)response,and regulating interferon-stimulated gene(ISG)expression and transcription.

参考文献/References:

[1] Catanese MT,Uryu K,Kopp M,et al.Ultrastructural analysis of hepatitis C virus particles[J].Proc Natl Acad Sci USA,2013,110(23):9505-9510.
[2] Fortes P,Morris KV.Long noncoding RNAs in viral infections[J].Virus Res,2016,212:1-11.
[3] Polaris Observatory HCV Collaborators.Global prevalence and genotype distribution of hepatitis C virus infection in 2015:A modelling study[J].Lancet Gastroenterol Hepatol,2017,2(3):161-176.
[4] Llovet JM,Villanueva A.Liver cancer: Effect of HCV clearance with direct-acting antiviral agents on HCC[J].Nat Rev Gastroenterol Hepatol,2016,13(10):561-562.
[5] Stanaway JD,Flaxman AD,Naghavi M,et al.The global burden of viral hepatitis from 1990 to 2013: Findings from the Global Burden of Disease Study 2013[J].Lancet,2016,388(10049):1081-1088.
[6] Bassendine MF,Sheridan DA,Bridge SH,et al.Lipids and HCV[J].Semin Immunopathol,2013,35(1):87-100.
[7] Zeisel MB,Fofana I,Fafi-Kremer S,et al.Hepatitis C virus entry into hepatocytes:Molecular mechanisms and targets for antiviral therapies[J].J Hepatol,2011,54(3):566-576.
[8] Ploss A,Evans MJ,Gaysinskaya VA,et al.Human occludin is a hepatitis C virus entry factor required for infection of mouse cells[J].Nature,2009,457(7231):882-886.
[9] Khakoo SI,Thio CL,Martin MP,et al.HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection[J].Science,2004,305(5685):872-874.
[10] Valadkhan S,Fortes P.Regulation of the interferon response by lncRNAs in HCV infection[J].Front Microbiol,2018,9:181.
[11] Gerlach JT,Diepolder HM,Jung MC,et al.Recurrence of hepatitis C virus after loss of virus-specific CD4(+)T-cell response in acute hepatitis C[J].Gastroenterology,1999,117(4):933-941.
[12] Schulze ZWJ,Ciuffreda D,Lewis-Ximenez L,et al.Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection,but rapidly disappear from human blood with viral persistence[J].J Exp Med,2012,209(1):61-75.
[13] Day CL,Seth NP,Lucas M,et al.Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class Ⅱ tetramers[J].J Clin Invest,2003,112(6):831-842.
[14] Spizzo R,Almeida MI,Colombatti A,et al.Long non-coding RNAs and cancer: A new frontier of translational research?[J].Oncogene,2012,31(43):4577-4587.
[15] 罗国强,秦彦昌,张百平,等.长链非编码RNA-ATB在胶质瘤中的表达水平和临床意义[J].陕西医学杂志,2019,48(7):831-833,849.
[16] 胡晋平,何丽洁,王汉民.长链非编码RNA在人类疾病中的研究进展[J].陕西医学杂志,2016,45(4):503-504.
[17] Ponting CP,Oliver PL,Reik W.Evolution and functions of long noncoding RNAs[J].Cell,2009,136(4):629-641.
[18] He Y,Meng XM,Huang C,et al.Long noncoding RNAs: Novel insights into hepatocelluar carcinoma[J].Cancer Lett,2014,344(1):20-27.
[19] Derrien T,Johnson R,Bussotti G,et al.The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure,evolution,and expression[J].Genome Res,2012,22(9):1775-1789.
[20] Wang KC,Chang HY.Molecular mechanisms of long noncoding RNAs[J].Mol Cell,2011,43(6):904-914.
[21] 张春艳,颜羽昕,梁 洁,等.长链非编码RNA在肝纤维化中的作用研究进展[J].解放军医学杂志,2021,46(2):186-192.
[22] Heo MJ,Yun J,Kim SG.Role of non-coding RNAs in liver disease progression to hepatocellular carcinoma[J].Arch Pharm Res,2019,42(1):48-62.
[23] Unfried JP,Fortes P.LncRNAs in HCV infection and HCV-related liver disease[J].Int J Mol Sci,2020,21(6):2255.
[24] Qian X,Xu C,Zhao P,et al.Long non-coding RNA GAS5 inhibited hepatitis C virus replication by binding viral NS3 protein[J].Virology,2016,492:155-165.
[25] Murray CL,Jones CT,Rice CM.Architects of assembly: Roles of flaviviridae non-structural proteins in virion morphogenesis[J].Nat Rev Microbiol,2008,6(9):699-708.
[26] Scheel TK,Rice CM.Understanding the hepatitis C virus life cycle paves the way for highly effective therapies[J].Nat Med,2013,19(7):837-849.
[27] Gupta RA,Shah N,Wang KC,et al.Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J].Nature,2010,464(7291):1071-1076.
[28] Li ZQ,Gu XY,Hu JX,et al.Hepatitis C virus core protein impairs metabolic disorder of liver cell via HOTAIR-Sirt1 signalling[J].Biosci Rep,2016,36(3):e00336.
[29] Barriocanal M,Fortes P.Long non-coding RNAs in Hepatitis C virus-infected cells[J].Front Microbiol,2017,8:1833.
[30] Perreira JM,Chin CR,Feeley EM,et al.IFITMs restrict the replication of multiple pathogenic viruses[J].J Mol Biol,2013,425(24):4937-4955.
[31] Narayana SK,Helbig KJ,Mccartney EM,et al.The interferon-induced transmembrane proteins,IFITM1,IFITM2,and IFITM3 inhibit hepatitis C virus entry[J].J Biol Chem,2015,290(43):25946-25959.
[32] Hattlmann CJ,Kelly JN,Barr SD.TRIM22: A diverse and dynamic antiviral protein[J].Mol Biol Int,2012,2012:153415.
[33] Yang C,Zhao X,Sun D,et al.Interferon alpha(IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A[J].Cell Mol Immunol,2016,13(1):94-102.
[34] Hertzog PJ,Williams BR.Fine tuning type Ⅰ interferon responses[J].Cytokine Growth Factor Rev,2013,24(3):217-225.
[35] Ivashkiv LB,Donlin LT.Regulation of type I interferon responses[J].Nat Rev Immunol,2014,14(1):36-49.
[36] Schneider WM,Chevillotte MD,Rice CM.Interferon-stimulated genes: A complex web of host defenses[J].Annu Rev Immunol,2014,32:513-545.
[37] Xie Q,Chen S,Tian R,et al.Long noncoding RNA ITPRIP-1 positively regulates the innate immune response through promotion of oligomerization and activation of MDA5[J].J Virol,2018,92(17):e00507-e00518.
[38] Zhou Y,Li M,Xue Y,et al.Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation[J].Cell Res,2019,29(8):641-654.
[39] Jiang M,Zhang S,Yang Z,et al.Self-recognition of an inducible host lncRNA by RIG-I feedback restricts innate immune response[J].Cell,2018,173(4):906-919.
[40] Fan J,Cheng M,Chi X,et al.A human long non-coding RNA lncATV promotes virus replication through restricting RIG-I-mediated innate immunity[J].Front Immunol,2019,10:1711.
[41] Peng X,Gralinski L,Armour CD,et al.Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling[J].Mbio,2010,1(5):e00206-e00210.
[42] Josset L,Tchitchek N,Gralinski LE,et al.Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts[J].RNA Biol,2014,11(7):875-890.
[43] Kambara H,Niazi F,Kostadinova L,et al.Negative regulation of the interferon response by an interferon-induced long non-coding RNA[J].Nucleic Acids Res,2014,42(16):10668-10680.
[44] Carnero E,Barriocanal M,Segura V,et al.Type I interferon regulates the expression of long non-coding RNAs[J].Front Immunol,2014,5:548.
[45] Barriocanal M,Carnero E,Segura V,et al.Long non-coding RNA BST2/BISPR is induced by IFN and regulates the expression of the antiviral factor tetherin[J].Front Immunol,2014,5:655.
[46] Kambara H,Gunawardane L,Zebrowski E,et al.Regulation of interferon-stimulated gene BST2 by a lncRNA transcribed from a shared bidirectional promoter[J].Front Immunol,2014,5:676.
[47] Neil SJ,Zang T,Bieniasz PD.Tetherin inhibits retrovirus release and is antagonized by HIV-1 vpu[J].Nature,2008,451(7177):425-430.
[48] Dafa-Berger A,Kuzmina A,Fassler M,et al.Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin[J].Virology,2012,428(2):98-111.
[49] Ouyang J,Zhu X,Chen Y,et al.NRAV,a long noncoding RNA,modulates antiviral responses through suppression of interferon-stimulated gene transcription[J].Cell Host Microbe,2014,16(5):616-626.
[50] Carnero E,Barriocanal M,Prior C,et al.Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication[J].EMBO Rep,2016,17(7):1013-1028.

相似文献/References:

[1]罗国强,秦彦昌,张百平,等.长链非编码RNA-ATB在胶质瘤中的表达水平和临床意义[J].陕西医学杂志,2019,(7):831.
 LUO Guoqiang,QIN Yanchang,ZHANG Baiping,et al.Expression level and clinical significance of long non-coding RNA ATB in gastric cancer[J].,2019,(3):831.
[2]车 宇,梁 静△,杨怡萍,等.沉默TUG1基因对肝门部胆管癌QBC939细胞增殖、凋亡及周期的影响[J].陕西医学杂志,2020,49(5):538.
 CHE Yu,LIANG Jing,YANG Yiping,et al.Effects of silencing TUG1 on the proliferation,apoptosis and cell cycle of QBC939 cells[J].,2020,49(3):538.
[3]舒 放,王海峰,薛飞肖,等.乙型肝炎病毒S基因不同区域嵌合丙型肝炎病毒中和抗原表位病毒样颗粒实验研究[J].陕西医学杂志,2021,50(6):660.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.005]
 SHU Fang,WANG Haifeng,XUE Feixiao,et al.Comparison of chimeric virus-like particles of HCV neutralizing epitopes in different regions of HBV S gene[J].,2021,50(3):660.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.005]
[4]洪 甲,杨 洋,栾丽霞.lncRNA-p23154通过miR-375/KLF4途径对SKOV3细胞增殖、侵袭的影响[J].陕西医学杂志,2021,50(11):1336.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.004]
 HONG Jia,YANG Yang,LUAN Lixia.Effect of lncRNA-p23154 on proliferation and invasion of SKOV3 cells through miR-375/Krüppel-like factor 4 pathway[J].,2021,50(3):1336.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.004]
[5]刘 娟,康星星.人类免疫缺陷病毒感染/获得性免疫缺陷综合征患者476例乙型、丙型肝炎病毒及梅毒螺旋体感染情况调查研究[J].陕西医学杂志,2021,50(12):1598.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.033]
 LIU Juan,KANG Xingxing.Investigation on HBV,HCV and TP infection in 476 HIV/AIDS patients[J].,2021,50(3):1598.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.033]
[6]张 媛,马 媛,鲁 杨,等.长链非编码RNA-kcnq1重叠转录物1通过负性调控miR-19a表达对人脐静脉内皮细胞功能影响实验研究[J].陕西医学杂志,2022,51(8):939.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.008]
 ZHANG Yuan,MA Yuan,LU Yang,et al.Effect of long non-coding RNA-kcnq1ot1 on the function of human umbilical vein endothelial cells by negatively regulating miR-19a expression[J].,2022,51(3):939.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.008]
[7]张 璐,郭含梦,王庆义.长链非编码RNA母系表达基因8通过微小RNA-495-3p调控急性髓性白血病细胞高迁移率族蛋白A1表达及对细胞增殖、凋亡的作用机制研究[J].陕西医学杂志,2024,(7):895.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.006]
 ZHANG Lu,GUO Hanmeng,WANG Qingyi.LncRNA MEG8 regulates HMGA1 expression and the mechanism of cell proliferation and apoptosis in acute myeloid leukemia cells through miR-495-3p[J].,2024,(3):895.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.006]
[8]王兴健,周巧艳,颜伟健,等.长链非编码lnc-FAF通过调控微小RNA-302a-3p保护缺氧复氧诱导肾小管上皮细胞的损伤[J].陕西医学杂志,2025,54(4):452.[doi:DOI:10.3969/j.issn.1000-7377.2025.04.004]
 WANG Xingjian,ZHOU Qiaoyan,YAN Weijian,et al.Lnc-FAF protects renal tubular epithelial cells from hypoxia-reoxygenation-induced injury by regulating miR-302a-3p[J].,2025,54(3):452.[doi:DOI:10.3969/j.issn.1000-7377.2025.04.004]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82160834); 广西壮族自治区自然科学基金资助项目(2021GXNSFBAO75020); 中西医结合广西一流学科(培育)建设项目[桂教科研(2018)12号]
更新日期/Last Update: 2022-03-04