[1]杨元利,张永峰,李爱芳,等.脑脊液腺苷脱氨酶水平检测在结核性脑膜炎早期诊断中的价值[J].陕西医学杂志,2022,51(3):363-365,369.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.023]
　YANG Yuanli,ZHANG Yongfeng,LI Aifang,et al.Value of adenosine deaminase level in cerebrospinal fluid in early diagnosis of tuberculous meningitis[J].,2022,51(3):363-365,369.[doi:DOI:10.3969/j.issn.1000-7377.2022.03.023]
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脑脊液腺苷脱氨酶水平检测在结核性脑膜炎早期诊断中的价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
51
期数:
2022年3期
页码:
363-365,369
栏目:
临床检验
出版日期:
2022-03-05

文章信息/Info

Title:
Value of adenosine deaminase level in cerebrospinal fluid in early diagnosis of tuberculous meningitis
作者:
杨元利; 张永峰; 李爱芳; 杜苏丰; 任 斐; 党丽云; 杨 翰
(西安市胸科医院,陕西 西安 710100)
Author(s):
YANG Yuanli; ZHANG Yongfeng; LI Aifang; DU Sufeng; REN Fei; DANG Liyun; YANG Han
(Xi'an Chest Hospital,Xi'an 710100,China)
关键词:
结核性脑膜炎;  腺苷脱氨酶;  脑脊液;  早期诊断价值;  受试者工作特征曲线
Keywords:
Tuberculous meningitis;  Adenosine deaminase;  Cerebrospinal fluid;  Early diagnostic value;  Receiver operating characteristic curve
分类号:
R 529.3
DOI:
DOI:10.3969/j.issn.1000-7377.2022.03.023
文献标志码:
A
摘要:
目的:探讨脑脊液(CSF)中腺苷脱氨酶(ADA)水平检测在结核性脑膜炎(TBM)早期诊断中的价值。方法:收集以头痛、发热、精神状态改变和脑膜刺激征为特征的疑似TBM患者65例为研究对象。根据确诊结果将所有患者分为TBM组(45例)和非TBM组(20例)。所有患者在住院后2周内进行腰椎穿刺术,留取CSF,检测并比较两组患者CSF中ADA水平。采用受试者工作特征(ROC)曲线评估ADA对TBM的早期诊断价值。结果:TBM组CSF中ADA水平在3～26 U/L,中位数(四分位数间距)为8(6,10)U/L。非TBM组CSF中ADA水平在0～5 U/L,中位数(四分位数间距)为1(0,2.75)U/L。TBM组患者CSF中ADA水平高于非TBM组(Z=-6.176,P<0.05)。ROC曲线分析结果显示,当CSF中ADA水平为4.5 U/L时,其诊断TBM的曲线下面积(AUC)为0.98,敏感度为93.33%,特异度为90.00%。结论:TBM患者CSF中ADA水平升高,在TBM早期诊断中具有较高的敏感性和特异性。
Abstract:
Objective:To investigate the value of adenosine deaminase(ADA)level in cerebrospinal fluid(CSF)in the early diagnosis of tuberculous meningitis(TBM).Methods:A total of 65 patients with suspected TBM characterized by headache,fever,mental state changes and meningeal irritation signs were collected.All patients were divided into TBM group(45 cases)and non TBM group(20 cases).All patients underwent lumbar puncture within 2 weeks after hospitalization,CSF was retained,and the level of ADA in CSF was detected and compared between the two groups.The receiver operating characteristic(ROC)curve was used to evaluate the value of ADA in the early diagnosis of TBM.Results:The level of ADA in CSF of TBM group was 3 to 26 U/L,and the median(interquartile interval)was 8(6,10)U/L.The level of ADA in CSF of non TBM group was 0 to 5 U/L,and the median(interquartile interval)was 1(0,2.75)U/L.The level of ADA in CSF in TBM group was higher than that in non TBM group(Z=-6.176,P<0.05).ROC curve analysis showed that when the ADA level in CSF was 4.5 U/L,the area under the curve(AUC)for the diagnosis of TBM was 0.98,the sensitivity was 93.33%,and the specificity was 90.00%.Conclusion:The level of ADA in CSF of patients with TBM is increased,which has high sensitivity and specificity in the early diagnosis of TBM.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2020SF-109)
更新日期/Last Update: 2022-03-04