[1]刘 娟,康星星.人类免疫缺陷病毒感染/获得性免疫缺陷综合征患者476例乙型、丙型肝炎病毒及梅毒螺旋体感染情况调查研究[J].陕西医学杂志,2021,50(12):1598-1601.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.033]
　LIU Juan,KANG Xingxing.Investigation on HBV,HCV and TP infection in 476 HIV/AIDS patients[J].,2021,50(12):1598-1601.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.033]
点击复制

人类免疫缺陷病毒感染/获得性免疫缺陷综合征患者476例乙型、丙型肝炎病毒及梅毒螺旋体感染情况调查研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1598-1601
栏目:
调查研究
出版日期:
2021-12-05

文章信息/Info

Title:
Investigation on HBV,HCV and TP infection in 476 HIV/AIDS patients
作者:
刘 娟; 康星星
(榆林市中医医院检验科,陕西 榆林 719000)
Author(s):
LIU Juan; KANG Xingxing
(Department of Laboratory Medicine,Yulin Hospital of Traditional Chinese Medicine,Yulin 719000,China)
关键词:
获得性免疫缺陷综合征;  人类免疫缺陷病毒;  乙型肝炎病毒;  丙型肝炎病毒;  梅毒螺旋体;  危险因素
Keywords:
Acquired immunodeficiency syndrome;  Human immunodeficiency virus;  Hepatitis B virus;  Hepatitis C virus;  Treponema pallidum;  Risk factors
分类号:
R 512.91
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.033
文献标志码:
A
摘要:
目的:调查并分析476例人类免疫缺陷病毒感染/获得性免疫缺陷综合征(HIV/AIDS)患者乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、梅毒螺旋体(TP)感染情况。方法:选择HIV/AIDS患者476例为研究对象,调查其合并HBV、HCV及TP感染情况,分析HIV/AIDS患者合并HBV、HCV及TP感染与人口学特征的关系,以及双重感染、三重感染及四重感染的危险因素。结果:所有HIV/AIDS患者中,HBV、HCV及TP感染率分别为9.87%、17.44%、5.46%,HBV+HCV、HBV+TP、HCV+TP感染率分别为4.20%、2.73%、3.57%,HBV+HCV+TP感染率为3.15%。HIV/AIDS患者双重感染与患者文化程度、民族、感染途径有关(均P<0.05),三重感染与患者年龄、感染途径有关(均P<0.05),四重感染与患者感染途径有关(P<0.05)。小学及以下学历、性传播、吸毒是HIV/AIDS患者双重感染的危险因素(均P<0.05),吸毒是HIV/AIDS患者三重感染的危险因素(P<0.05),性传播是HIV/AIDS患者四重感染危险因素(均P<0.05)。结论:HIV/AIDS患者较易合并HBV、HCV及TP感染,双重感染、三重感染以及四重感染影响因素各不相同,需要及时进行评估。
Abstract:
Objective:To investigate and analyze the infection of HBV,HCV and TP in 476 patients with HIV/AIDS.Methods:476 HIV/AIDS patients were selected as the research objects.The infection of HBV,HCV and TP in HIV/AIDS patients were investigated.The relationship between HBV,HCV,TP infection and demographic characteristics,as well as the risk factors of double infection,triple infection and quadruple infection were analyzed.Results:Among all HIV/AIDS patients,the infection rates of HBV,HCV and TP were 9.87%,17.44% and 5.46% respectively,the infection rates of HBV+HCV,HBV+TP and HCV+TP were 4.20%,2.73% and 3.57% respectively,and the infection rate of HBV+HCV+TP was 3.15%.The double infection of HIV/AIDS patients was related to their educational level,nationality and route of infection(all P<0.05),the triple infection was related to their age and route of infection(all P<0.05),and the quadruple infection was related to their route of infection(P<0.05).Primary school education or below,sexual transmission and drug abuse were the risk factors of double infection in HIV/AIDS patients(all P<0.05),drug abuse was the risk factor of triple infection in HIV/AIDS patients(P<0.05),and sexual transmission was the risk factor of quadruple infection in HIV/AIDS patients(all P<0.05).Conclusion:HIV/AIDS patients are more likely to be complicated with HBV,HCV and TP infection.The influencing factors of double infection,triple infection and quadruple infection are different,which need to be evaluated in time.

参考文献/References:

[1] 邱邦东,徐全敏.抗HIV治疗艾滋病合并丙型肝炎对患者T淋巴细胞亚群、NK细胞及HIV载量的影响[J].陕西医学杂志,2019,48(12):1619-1621.
[2] 李政伟,金艳涛,李鹏宇,等.老年HIV/AIDS患者贫血及其影响因素分析[J].中国皮肤性病学杂志,2017,31(4):442-444.
[3] 王译葵,陈晓晨,王继宝,等.德宏傣族景颇族自治州2016年HIV/HCV合并感染者HCV分子传播簇分析[J].中华流行病学杂志,2019,40(2):191-195.
[4] 谭 婷,余惠芬,马艳玲,等.美沙酮维持治疗人群中HIV/HCV双重感染者的HCV治疗现状及影响因素[J].中国艾滋病性病,2018,24(7):683-686,717.
[5] 田 波,何利平,刘 俊,等.HIV合并HBV/HCV病人抗病毒治疗5年疗效及生存状况分析[J].中国艾滋病性病,2020,26(7):701-704.
[6] 邵一鸣,康来仪,汪 宁,等.艾滋病和艾滋病病毒感染诊断标准[J].中国艾滋病性病,2012,18(4):272-274.
[7] Franzetti M,Ricci E,Bonfanti P.The pattern of non-AIDS-defining cancers in the HIV population:Epidemiology,risk factors and prognosis.A review[J].Curr HIV Res,2019,17(1):1-12.
[8] Furukawa Y,Hamada H,Kamikawaji K,et al.Successful treatment of an AIDS patient with prolonged mycobacterium avium bacteremia,high HIV RNA,HBV infection,Kaposi's sarcoma and cytomegalovirus retinitis[J].J Infect Chemother,2020,26(2):279-281.
[9] Karic U,Milosevic I,Pesic-Pavlovic I,et al.The treatment outcome of chronic HBV infection among HBV/HIV co-infected and HBV mono-infected patients[J].Int J STD AIDS,2020,31(1):38-45.
[10] 倪修文,徐利强,李建华,等.嘉兴地区献血人群隐匿性乙肝病毒感染血清学及病毒学特征研究[J].中国输血杂志,2017,7(95):130-134.
[11] 徐 玲,戴国瑞,种雪静,等.HIV/AIDS病人HBV HCV梅毒感染率的调查分析[J].中国艾滋病性病,2017,23(2):138-141.
[12] 陆亭屹,王明祥,吴耀品,等.黔南地区艾滋病重叠丙型肝炎、梅毒感染现状及其相关性研究[J].中国卫生检验杂志,2016,26(9):1319-1321.
[13] Bailey H,Turkova A,Thorne C.Syphilis,hepatitis C and HIV in Eastern Europe[J].Curr Opin Infect Dis,2017,30(1):93-100.
[14] 朱晓娟,吴晓芳,徐德顺,等.HIV/AIDS病人合并梅毒感染及其对免疫功能的影响[J].中国艾滋病性病,2020,26(10):1066-1068.
[15] 刘 薇,刘建忠,阮连国,等.武汉市HIV/AIDS病人合并乙肝,丙肝感染情况分析[J].现代预防医学,2020,47(10):151-153,169.
[16] 穆金萍,宋 巍,王 路.2008-2017年沈阳市艾滋病疫情流行特征分析[J].现代预防医学,2018,45(16):2894-2897,2949.
[17] Audsley J,Avihingsanon A,Littlejohn M,et al.Long-term TDF-inclusive ART and progressive rates of HBsAg loss in HIV-HBV coinfection-lessons for functional HBV cure?[J].J Acquir Immune Defic Syndr,2020,84(5):527-533.
[18] Leoni MC,Ustianowski A,Farooq H,et al.HIV,HCV and HBV:A review of parallels and differences[J].Infect Dis Ther,2018,7(4):407-419.
[19] Kelly-Hedrick M,Gross MS.HIV-,HBV-,and HCV-related information on U.S.fertility clinic websites:A content analysis[J].Health Equity,2020,4(1):345-352.
[20] 霍 炜,李一苇,刘 芳,等.菏泽市2010-2016年艾滋病的流行病学特征分析[J].中国艾滋病性病,2018,24(2):186-188.

相似文献/References:

[1]石 英,徐苏丽△.男性艾滋病患者艾滋病相关病原体及血清指标检测价值分析[J].陕西医学杂志,2020,49(9):1175.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.031]
　SHI Ying,XU Suli..Detection value of AIDS-related pathogens and serum indicators in male AIDS patients[J].,2020,49(12):1175.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.031]

备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2020SF-220)
更新日期/Last Update: 2021-12-07