[1]孙春晖,乐 原.川崎病合并冠状动脉病变患儿前白蛋白、胱抑素C、血小板四项变化及临床意义[J].陕西医学杂志,2021,50(12):1573-1576.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.027]
　SUN Chunhui,LE Yuan.Changes and clinical significance of prealbumin,cystatin C and four parameters of platelet in Kawasaki disease children with coronary arterial lesions[J].,2021,50(12):1573-1576.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.027]
点击复制

川崎病合并冠状动脉病变患儿前白蛋白、胱抑素C、血小板四项变化及临床意义
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1573-1576
栏目:
临床检验
出版日期:
2021-12-05

文章信息/Info

Title:
Changes and clinical significance of prealbumin,cystatin C and four parameters of platelet in Kawasaki disease children with coronary arterial lesions
作者:
孙春晖1; 2; 乐 原1
(1.锦州医科大学附属第一医院儿科,辽宁 锦州 121001; 2.朝阳市第二医院儿科,辽宁 朝阳 122000)
Author(s):
SUN Chunhui; LE Yuan
(Department of Pediatrics,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
关键词:
川崎病;  冠状动脉病变;  前白蛋白;  胱抑素C;  血小板四项
Keywords:
Kawasaki disease;  Coronary arterial lesions;  Prealbumin;  Cystatin C;  Four parameters of platelet
分类号:
R 725.4
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.027
文献标志码:
A
摘要:
目的:探讨川崎病(KD)合并冠状动脉病变(CAL)患儿前白蛋白(PA)、胱抑素C(CysC)、血小板四项变化及临床意义。方法:选取KD患儿38例作为KD组,KD合并CAL患儿42例作为KD合并CAL组。选取同期接受体检的健康儿童40例作为对照组。比较三组PA、CysC、血小板计数(PLT)、血小板平均体积(MPV)、血小板比容(PCT)、血小板分布宽度(PDW)水平。对KD组和KD合并CAL组患儿采用原田危险评分(Harada评分)和小林评分(Kobayashi评分)进行疾病风险评分,并分析PA、CysC、PLT、MPV、PCT、PDW水平与Harada评分、Kobayashi 评分的相关性。结果:KD合并CAL组和KD组患儿PA水平明显低于对照组,CysC水平明显高于对照组(均P<0.05)。KD合并CAL组患儿PA水平明显低于KD组,CysC水平明显高于KD组(均P<0.05)。KD合并CAL组和KD组患儿PLT、MPV、PCT、PDW水平高于对照组,且KD合并CAL组高于KD组(均P<0.05)。Pearson相关性分析结果显示,PA水平与Harada评分、Kobayashi 评分均呈负相关,CysC和血小板四项水平与Harada评分、Kobayashi评分均呈正相关(均P<0.05)。结论:KD合并CAL患儿CysC、血小板四项水平明显升高,PA水平明显降低,对PA、CysC、血小板四项的检测有助于评估患儿病情。
Abstract:
Objective:To investigate the changes and clinical significance of prealbumin(PA),cystatin C(CysC)and four parameters of platelet in Kawasaki disease(KD)children with coronary arterial lesions(CAL).Methods:38 KD children were selected as the KD group,and 42 KD children with CAL were selected as the KD combined CAL group.Forty healthy children who underwent physical examination during the same period were selected as the control group.The three groups of PA,CysC,platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT),platelet distribution width(PDW)levels were compared.The Harada score and Kobayashi score were used for disease risk scores for children in the KD group and the KD combined CAL group,and the correlation between the levels of PA,CysC,PLT,MPV,PCT,PDW and Harada score and Kobayashi score were analyzed.Results:The PA level of children in the KD combined CAL group and the KD group was significantly lower than that of the control group,and the CysC level was significantly higher than that of the control group(all P<0.05).The PA level of children in the KD combined CAL group was significantly lower than that of the KD group,and the CysC level was significantly higher than that of the KD group(all P<0.05).The levels of PLT,MPV,PCT and PDW in the KD combined CAL group and KD group were higher than those of the control group,and the KD combined CAL group was higher than the KD group(all P<0.05).Pearson correlation analysis showed that PA level was negatively correlated with Harada score and Kobayashi score,and the levels of CysC and four parameters of platelet were positively correlated with Harada score and Kobayashi score(all P<0.05).Conclusion:The levels of CysC and four parameters of platelet in KD children with CAL are significantly increased,and the level of PA is significantly reduced.The detection of PA,CysC and four parameters of platelet is helpful to assess the condition of the children.

参考文献/References:

[1] He L,Liu F,Huang GY,et al.Application of selective coronary angiography in children with Kawasaki disease complicated with severe coronary artery lesion[J].Chin J Pediatr,2019,57(2):108-112.
[2] Jakob A,Schachinger E,Klau S,et al.Von willebrand factor parameters as potential biomarkers for disease activity and coronary artery lesion in patients with Kawasaki disease[J].Eur J Pediatr,2020,179(3):377-384.
[3] 邢 前.血清白蛋白、血小板反应蛋白1及血小板反应蛋白2水平对川崎病患儿发生静脉注射免疫球蛋白抵抗的预测价值[J].广西医学,2019,41(16):2059-2062.
[4] 刘慧兰,李晓宁,付 帅,等.血清胱抑素C对急性冠脉综合征患者急性肾损伤发病和预后的预测价值[J].临床肾脏病杂志,2019,19(7):482-487.
[5] 杨艳章,王 莉,杨艳芳,等.川崎病患儿并发冠状动脉病变相关危险因素与治疗分析[J].中国妇幼保健,2019,34(14):3244-3246.
[6] 中华医学会儿科学分会心血管学组,中华儿科杂志编辑委员会.川崎病冠状动脉病变的临床处理建议(2020年修订版)[J].中华儿科杂志,2020,58(9):718-724.
[7] 刘 静,马金海,蒋立夏.Kobayashi、Harada两种评分体系预测川崎病冠状动脉损害的价值分析[J].中国妇幼保健,2019,34(24):5704-5707.
[8] Maccora I,Calabri GB,Favilli S,et al.Long-term follow-up of coronary artery lesions in children in Kawasaki syndrome[J].Eur J Pediatr,2021,180(1):271-275.
[9] Duan J,Jiang H,Lu M.Risk factors for coronary artery lesions in children with Kawasaki disease[J].Arch Argent Pediatr,2020,118(5):327-331.
[10] 李 垚,陈万林,杨 平,等.与冠心病患者冠状动脉病变及叶酸水平相关性研究[J].陕西医学杂志,2021,50(1):22-25.
[11] 龚 华,林 辉,刘 伟,等.术后早期肠内免疫营养对大肠癌患者营养状态、免疫功能和炎症反应的影响[J].陕西医学杂志,2019,48(5):575-577,580.
[12] 马红玲,宁立芬.血清C反应蛋白、B型脑钠肽、降钙素原和前白蛋白检测对小儿急性呼吸道感染病情诊断和疗效评估的价值[J].川北医学院学报,2020,35(1):52-56.
[13] 钟凯丽.胱抑素C、血肌酐联合尿肌酐、尿素氮检测对代谢综合征患者早期肾损害的诊断价值[J].检验医学与临床,2019,16(21):3204-3207.
[14] 庞连胜,赵万春.血清CysC、尿β2-MG、尿mAlb三项联合检测对肝癌及肝硬化继发早期肾功能损伤的诊断价值[J].肝脏,2019,24(6):649-652.
[15] 朱小川.血小板/淋巴细胞比值预测慢性阻塞性肺疾病急性加重期伴有早期肾功能损害临床价值[J].陕西医学杂志,2019,48(10):1352-1354,1392.
[16] 朱再富,范晓晨.川崎病患儿红细胞分布宽度变化及意义[J].临床儿科杂志,2020,38(3):182-185.
[17] 刘 倩,范晓晨.血浆前清蛋白对川崎病患儿冠状动脉病变的预测意义[J].安徽医学,2020,41(4):389-392.
[18] 王 建,刘晓红,陈若诗,等.血清胱抑素C与常见心血管疾病的关系[J].中国介入心脏病学杂志,2020,28(10):585-588.
[19] 吴 凡,汤卫红,叶 姗,等.川崎病急性期血清胱抑素C水平与冠脉病变的关系[J].中国妇幼健康研究,2020,31(6):717-721.
[20] 赖雪芹,赵 青,郭健秋,等.N端前脑钠肽与原田危险评分、小林评分对川崎病病儿冠状动脉病变风险预测价值的对比[J].安徽医药,2020,24(4):688-691.

相似文献/References:

[1]穆志龙,高 颖△,卫 丽,等.热休克蛋白60、70在川崎病冠状动脉病变中的表达及意义*[J].陕西医学杂志,2020,49(9):1117.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.016]
　MU Zhilong,GAO Ying,WEI Li,et al.Expression and significance of HSP60 and HSP70 in coronary artery disease of Kawasaki disease[J].,2020,49(12):1117.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.016]
[2]杨荣荣,马佳娜△.超声心动图和心肌酶学检测在患儿川崎病合并冠状动脉病变诊断中的应用*[J].陕西医学杂志,2020,49(10):1259.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.015]
　YANG Rongrong,MA Jiana..Application value analysis of echocardiography and myocardial enzyme indexes in children with Kawasaki disease complicated with coronary artery disease[J].,2020,49(12):1259.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.015]
[3]李佳娜,艾世宜,李 星.老年高血压合并冠心病患者血压晨峰与血清可溶性血管黏附因子1和干扰素γ相关性分析[J].陕西医学杂志,2021,50(7):825.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.014]
　LI Jia'na,AI Shiyi,LI Xing.Correlation between morning peak of blood pressure and serum sVCAM-1 and IFN-γ in elderly patients with hypertension and coronary heart disease[J].,2021,50(12):825.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.014]
[4]严晓华,王 娜,马 娟,等.阿托伐他汀对小鼠川崎病的治疗作用及机制研究[J].陕西医学杂志,2022,51(6):672.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.007]
　YAN Xiaohua,WANG Na,MA Juan,et al.Therapeutic effect and mechanism of atorvastatin on Kawasaki disease mice[J].,2022,51(12):672.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.007]
[5]寇志军,李 静,马亨曼,等.川崎病患儿心血管病变易感性与血清N末端B型脑钠肽原、前白蛋白及C-反应蛋白表达水平相关性研究[J].陕西医学杂志,2022,51(6):717.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.018]
　KOU Zhijun,LI Jing,MA Hengman,et al.Correlation between cardiovascular disease susceptibility and serum levels of NT-proBNP,PA and CRP in children with Kawasaki disease[J].,2022,51(12):717.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.018]
[6]张凤梅,蔡 颖,吴 迪,等.多不饱和脂肪酸ω-3/多不饱和脂肪酸ω-6与冠状动脉病变相关性研究[J].陕西医学杂志,2023,52(10):1326.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.009]
　ZHANG Fengmei,CAI Ying,WU Di,et al.Research on correlation of ω-3,ω-6 and their ratio with coronary artery disease[J].,2023,52(12):1326.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.009]
[7]赵 萌,杨轶童,李翰文,等.肠道微生物菌群与川崎病关系研究进展[J].陕西医学杂志,2024,(2):270.[doi:DOI:10.3969/j.issn.1000-7377.2024.02.027]
　ZHAO Meng,YANG Yitong,LI Hanwen,et al.Research progress on relationship between gut microbiota and Kawasaki disease[J].,2024,(12):270.[doi:DOI:10.3969/j.issn.1000-7377.2024.02.027]
[8]贾臣英,李建丽,袁帅朋,等.英国前瞻性糖尿病研究评分联合下肢动脉病变分级对2型糖尿病患者冠状动脉病变程度的预测价值[J].陕西医学杂志,2024,(9):1193.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.008]
　JIA Chenying,LI Jianli,YUAN Shuaipeng,et al.Predictive value of UKPDS score combined with lower extremity arterial disease classification in coronary artery lesion degree of T2DM patients[J].,2024,(12):1193.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.008]
[9]耿 鹃,周 耀,刘旭辉.微小RNA-492、红细胞微粒水平与ST段抬高型急性心肌梗死患者冠状动脉病变严重程度关系研究[J].陕西医学杂志,2024,(9):1249.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.021]
　GENG Juan,ZHOU Yao,LIU Xuhui.Relationship between level of miR-492,erythrocyte microparticles and severity of coronary artery lesions in STEMI patients[J].,2024,(12):1249.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.021]
[10]冷 俊,郁 淼,秦 兵,等.血清可溶性生长刺激表达基因2蛋白、胱抑素C、C反应蛋白与冠状动脉病变严重程度的相关性及预后影响因素分析[J].陕西医学杂志,2025,54(1):114.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.023]
　LENG Jun,YU Miao,QIN Bing,et al.Correlation between serum sST2,CysC,CRP and severity of coronary artery disease and prognostic factors[J].,2025,54(12):114.[doi:DOI:10.3969/j.issn.1000-7377.2025.01.023]
[11]冯千伟,王晓青,焦丽华,等.川崎病患儿血清血管生成素样蛋白8、生长分化因子-15水平与并发冠状动脉病变关系研究[J].陕西医学杂志,2025,54(3):364.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.015]
　FENG Qianwei,WANG Xiaoqing,JIAO Lihua,et al.Relationship between serum ANGPTL8,GDF-15 levels with concurrent coronary artery disease in children with Kawasaki disease[J].,2025,54(12):364.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.015]

备注/Memo

备注/Memo:
基金项目:辽宁省自然科学基金资助项目(20170540440)
更新日期/Last Update: 2021-12-07