[1]郭武辉,张 华.血清T淋巴细胞亚群检测在肝硬化合并真菌性血流感染中的诊断价值[J].陕西医学杂志,2021,50(12):1570-1572,1576.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.026]
　GUO Wuhui,ZHANG Hua.Diagnostic value of serum T lymphocyte subsets detection in liver cirrhosis complicated with fungal bloodstream infection[J].,2021,50(12):1570-1572,1576.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.026]
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血清T淋巴细胞亚群检测在肝硬化合并真菌性血流感染中的诊断价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1570-1572,1576
栏目:
临床检验
出版日期:
2021-12-05

文章信息/Info

Title:
Diagnostic value of serum T lymphocyte subsets detection in liver cirrhosis complicated with fungal bloodstream infection
作者:
郭武辉1; 张 华2
(1.榆林市第二医院医学检验科,陕西 榆林 719000; 2.西安市儿童医院儿童重症监护科,陕西 西安 710002)
Author(s):
GUO Wuhui; ZHANG Hua
(Department of Medical Laboratory Science,Yulin No.2 Hospital,Yulin 719000,China)
关键词:
肝硬化;  真菌性血流感染;  T淋巴细胞亚群;  联合检测;  诊断价值
Keywords:
Liver cirrhosis;  Fungal bloodstream infection;  T lymphocyte subsets;  Combined detection;  Diagnostic value
分类号:
R 657.31
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.026
文献标志码:
A
摘要:
目的:探究血清T淋巴细胞亚群检测在肝硬化合并真菌性血流感染中的诊断价值。方法:选择肝硬化合并真菌性血流感染患儿60例为研究组,选择同期接受治疗的肝硬化患儿50例为病例对照组,选择健康儿童50例为对照组。对比三组儿童血清T淋巴细胞亚群(CD4+、CD3+及CD4+/CD8+)以及炎症指标[降钙素原(PCT)、白细胞(WBC)及中性粒细胞(NE)]水平。绘制受试者工作特征(ROC)曲线,分析CD4+、CD3+及CD4+/CD8+对肝硬化合并真菌性血流感染的诊断价值。结果:研究组和病例对照组患儿CD4+、CD3+及CD4+/CD8+水平均显著低于对照组,且研究组患儿CD4+、CD3+及CD4+/CD8+明显低于病例对照组(均P<0.05)。研究组和病例对照组患儿PCT、WBC以及NE水平均明显高于对照组,且研究组患儿上述指标水平明显高于病例对照组(均P<0.05)。CD4+、CD3+、CD4+/CD8+单项、两项联合以及三项联合均对肝硬化合并真菌性血流感染具有较高的诊断价值,尤其是三项联合,曲线下面积(AUC)为0.951。结论:CD4+、CD3+及CD4+/CD8+联合检测对肝硬化合并真菌性血流感染具有较好的诊断价值,可以考虑将其作为该症的早期诊断指标。
Abstract:
Objective:To explore the diagnostic value of serum T lymphocyte subsets detection in liver cirrhosis complicated with fungal bloodstream infection.Methods:60 children with liver cirrhosis complicated with fungal bloodstream infection were selected as the study group,50 children with liver cirrhosis during the same period were selected as the case control group,and 50 healthy children were selected as the control group.The three groups of serum T lymphocyte subsets(CD4+,CD3+ and CD4+/CD8+)and inflammation indicators [procalcitonin(PCT),white blood cells(WBC)and neutrophils(NE)] levels were compared.ROC curve was used to analyze the diagnostic value of CD4+,CD3+ and CD4+/CD8+ in liver cirrhosis with fungal bloodstream infection.Results:The CD4+,CD3+ and CD4+/CD8+ levels of the study group and the case control group were significantly lower than those of the control group,and the CD4+,CD3+ and CD4+/CD8+ levels of the study group were significantly lower than those of the case control group(all P<0.05).The levels of PCT,WBC and NE in the study group and the case control group were significantly higher than those in the control group,and the levels of the above indicators in the study group were significantly higher than those in the case control group(all P<0.05).Among CD4+,CD3+ and CD4+/CD8+,the detection of single index,two indexes and three indexes have high diagnostic value for liver cirrhosis complicated with fungal bloodstream infection,especially the three combination,the AUC was 0.951.Conclusion:The combined detection of CD4+,CD3+ and CD4+/CD8+ has a good diagnostic value for liver cirrhosis complicated with fungal bloodstream infection,which can be considered as early diagnosis indexes for this disease.

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备注/Memo

备注/Memo:
基金项目:国家重点研发计划项目(2019YFF0216502)
更新日期/Last Update: 2021-12-07