[1]马 兵,张丽红,赵 丹,等.急性髓系白血病患者巨噬细胞移动抑制因子表达水平及其与疗效、预后相关性分析[J].陕西医学杂志,2021,50(12):1558-1561.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.023]
　MA Bing,ZHANG Lihong,ZHAO Dan,et al.Expression level of macrophage migration inhibitory factor in AML patients and its correlation with curative effect and prognosis[J].,2021,50(12):1558-1561.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.023]
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急性髓系白血病患者巨噬细胞移动抑制因子表达水平及其与疗效、预后相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1558-1561
栏目:
临床研究
出版日期:
2021-12-05

文章信息/Info

Title:
Expression level of macrophage migration inhibitory factor in AML patients and its correlation with curative effect and prognosis
作者:
马 兵; 张丽红; 赵 丹; 尹婉宜; 沈 扬; 董 雯; 刘清池
(河北医科大学第一医院血液内科,河北 石家庄 050031)
Author(s):
MA Bing; ZHANG Lihong; ZHAO Dan; YIN Wanyi; SHEN Yang; DONG Wen; LIU Qingchi
(Department of Hematology,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China)
关键词:
急性髓系白血病;  巨噬细胞移动抑制因子;  骨髓液;  外周血;  疗效;  预后;  相关性
Keywords:
Acute myeloid leukemia;  Macrophage migration inhibitory factor;  Bone marrow fluid;  Peripheral blood;  Curative effect;  Prognosis;  Correlation
分类号:
R 733.71
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.023
文献标志码:
A
摘要:
目的:检测急性髓系白血病(AML)患者巨噬细胞移动抑制因子(MIF)表达水平,分析其与疗效及预后的相关性。方法:选取AML初诊患者132例,检测骨髓液及外周血中标本MIF表达水平。比较不同临床特征及不同疗效AML患者MIF表达水平。比较不同MIF表达水平患者无病生存期(DFS)。分析AML患者MIF表达水平与疗效及预后的相关性。结果:不同性别及抗原类型的AML患者骨髓液和外周血中MIF表达水平比较,差异无统计学意义(均P>0.05)。≥45岁AML患者骨髓液及外周血中MIF表达水平高于<45岁患者,骨髓原始细胞数≥60%的AML患者骨髓液及外周血中MIF表达水平高于<60%的患者(均P<0.05)。治疗有效患者骨髓液及外周血中MIF表达水平均明显低于治疗无效患者(均P<0.05)。以所有患者入院初诊时MIF表达水平中位数为临界值分为高表达组及低表达组,发现高表达组患者DFS低于低表达组(P<0.05)。Spearman相关性分析显示,骨髓液及外周血中MIF表达水平与AML患者疗效及DFS呈负相关(均P<0.05)。结论:AML患者MIF表达水平显著升高,并与疗效及预后呈负相关。
Abstract:
Objective:To detect the expression level of macrophage migration inhibitory factor(MIF)in patients with acute myeloid leukemia(AML),and to analyze its correlation with curative effect and prognosis.Methods:A total of 132 initially diagnosed AML patients were selected,and MIF expression levels in bone marrow fluid and peripheral blood samples were detected.The expression levels of MIF in AML patients with different clinical characteristics and different curative effects were compared.The disease-free survival(DFS)of patients with different MIF expression levels was compared.The correlation between the expression level of MIF in AML patients and the curative effect and prognosis was analyzed.Results:There was no significant difference in the expression level of MIF in bone marrow fluid and peripheral blood of AML patients of different genders and antigen types(all P>0.05).MIF expression levels in bone marrow fluid and peripheral blood of AML patients with ≥45 years were higher than those of patients with <45 years,and MIF expression levels in bone marrow fluid and peripheral blood of AML patients with ≥60% bone marrow blast cells were higher than those in patients with <60%(all P<0.05).The expression level of MIF in bone marrow fluid and peripheral blood of patients with effective treatment was significantly lower than that of patients with treatment failure(all P<0.05).All patients were divided into high-expression group and low-expression group based on the median of MIF expression level when they were first admitted to the hospital,and it was found that the DFS of the high-expression group was lower than that of the low-expression group(P<0.05).Spearman correlation analysis showed that the expression level of MIF in bone marrow fluid and peripheral blood was negatively correlated with the curative effect and DFS of AML patients(all P<0.05).Conclusion:The expression level of macrophage migration inhibitory factor in acute myeloid leukemia patients is significantly increased and negatively correlated with curative effect and prognosis.

参考文献/References:

[1] 王雪梅,汤久慧,王茂生,等.参芪杀白汤为主联合化疗治疗急性白血病合并脾周围炎临床研究[J].陕西中医,2020,41(2):202-205.
[2] Rees-Punia E,Patel AV,Fallon EA,et al.Physical activity,sitting time,and risk of myelodysplastic syndromes,acute myeloid leukemia,and other myeloid malignancies[J].Cancer Epidemiology Biomarkers & Prevention,2019,28(9):1489-1494.
[3] 苗 朋,张 瑞,吴淑贞,等.急性白血病患者死亡焦虑与自尊、自我效能感的相关性[J].中国健康心理学杂志,2020,28(11):1609-1612.
[4] Estey EH.Acute myeloid leukemia:2019 update on risk-stratification and management[J].American Journal of Hematology,2018,93(10):1267-1291.
[5] Castro BA,Flanigan P,Jahangiri A,et al.Macrophage migration inhibitory factor downregulation:A novel mechanism of resistance to anti-angiogenic therapy[J].Oncogene,2017,36(26):3749-3759.
[6] Antar F,Ahmed HM,Salaheldeen HM,et al.Macrophage migration inhibitory factor as an incriminating agent in vitiligo[J].An Bras Dermatol,2018,93(2):191-196.
[7] 孙连桃,肖伟利.巨噬细胞移动抑制因子在肾癌中的表达及对肾癌细胞侵袭能力的影响[J].重庆医学,2017,46(35):4897-4900.
[8] 李 冰,杨元立,王美霞,等.巨噬细胞移动抑制因子在慢性阻塞性肺疾病患者肺组织中的表达及意义[J].中华急诊医学杂志,2019,28(9):1123-1127.
[9] 中华医学会血液学分会白血病淋巴瘤学组.成人急性髓系白血病(非急性早幼粒细胞白血病)中国诊疗指南(2017年版)[J].中华血液学杂志,2017,38(3):177-182.
[10] 张之南,沈 悌.血液病诊断及疗效标准[M].3版.北京:科学出版社,2007:139-144.
[11] 孙淑华,赵立双,刘恩君.白血病患者心理状况及医学应对方式的研究[J].中国健康心理学杂志,2008,16(8):948-949.
[12] 田 淼,晁 旭,何春玲,等.急性白血病患者血清PDGF、HMGB1及相关血管内皮生长因子表达水平研究[J].陕西医学杂志,2017,46(4):508-509.
[13] 刘兵华,王思尧,李 莉.血淸巨噬细胞迁移抑制因子在冠心病患者中表达水平及与病变严重程度的相关性研究[J].心肺血管病杂志,2019,38(2):137-141.
[14] 江晓珍,邓 葵,花美玲,等.巨噬细胞移动抑制因子影响胶质瘤细胞迁移,凋亡的机制[J].中华病理学杂志,2019,48(2):108-111.
[15] 李焕杰.p53蛋白和MDR表型在白血病中的共表达研究[J].基因组学与应用生物学,2019,38(12):5664-5670.
[16] 岑 岭,姜 玉,张修文,等.老年与非老年急性单核细胞白血病的细胞遗传学分析[J].中华医学遗传学杂志,2017,34(4):611-613.
[17] Salminen A,Kai K.Control of p53 and NF-κB signaling by WIP1 and MIF:Role in cellular senescence and organismal aging[J].Cellular Signalling,2011,23(5):747-752.
[18] 方 瑜,陈光伟,杨 洋,等.在宫颈癌治疗中对MIF、VEGF-C、P53表达及肿瘤生长的影响[J].基因组学与应用生物学,2018,37(9):4148-4154.
[19] 马颖光,韩云志,张自森,等.miR-451靶向巨噬细胞移动抑制因子对结直肠癌细胞增殖迁移的影响及其作用机制[J].中华肿瘤杂志,2020,42(4):312-318.
[20] 成荣杰,李 楠.CD74介导巨噬细胞移动抑制因子对宫颈癌细胞生物学行为的影响[J].中国实验诊断学,2020,24(10):1689-1693.
[21] 张娟娟,陈耐寒,左荣霞,等.急性髓系白血病巨噬细胞移动抑制因子表达及其对骨髓间充质干细胞白细胞介素8表达的影响[J].白血病?淋巴瘤,2020,29(8):465-470.

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备注/Memo

备注/Memo:
基金项目:河北省医学科学研究课题(20201165)
更新日期/Last Update: 2021-12-07