[1]乔 敏,马春宁,王艳莉.双源CT标准化碘浓度、能谱曲线斜率与肺腺癌分化程度和淋巴结转移的关系[J].陕西医学杂志,2021,50(12):1539-1541,1545.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.018]
　QIAO Min,MA Chunning,WANG Yanli.Relationship between iodine concentration,normalized iodine concentration,energy spectrum curve slope detected by dual-source CT and differentiation degree,lymph node metastasis of lung adenocarcinoma[J].,2021,50(12):1539-1541,1545.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.018]
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双源CT标准化碘浓度、能谱曲线斜率与肺腺癌分化程度和淋巴结转移的关系
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1539-1541,1545
栏目:
临床研究
出版日期:
2021-12-05

文章信息/Info

Title:
Relationship between iodine concentration,normalized iodine concentration,energy spectrum curve slope detected by dual-source CT and differentiation degree,lymph node metastasis of lung adenocarcinoma
作者:
乔 敏1; 马春宁2; 王艳莉3
(1.商洛市中心医院CT室,陕西 商洛 726000; 2.咸阳市中心医院CT室,陕西 咸阳 712000; 3.咸阳市第一人民医院急危重症科,陕西 咸阳 712000)
Author(s):
QIAO Min; MA Chunning; WANG Yanli
(CT Room,Shangluo Central Hospital,Shangluo 726000,China)
关键词:
肺腺癌;  淋巴结转移;  分化程度;  双源CT;  标准化碘浓度;  相关性
Keywords:
Lung adenocarcinoma;  Lymph node metastasis;  Differentiation degree;  Dual-source CT;  Normalized iodine concentration;  Correlation
分类号:
R 734.2
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.018
文献标志码:
A
摘要:
目的:分析双源CT标准化碘浓度(NIC)、能谱曲线斜率(k)与肺腺癌分化程度和淋巴结转移的关系。方法:回顾性分析297例肺腺癌患者临床资料,其中高分化71例,中分化132例,低分化组94例; 有淋巴结转移164例,无淋巴结转移133例。所有患者术前均接受双源CT检查,术后经病理学检查确诊。比较不同分化程度及有无淋巴结转移患者双源CT指标(肿瘤大小、碘浓度、NIC、k值)的差异,分析碘浓度、NIC、k值与微血管密度(MVD)的相关性。结果:不同分化程度患者肿瘤大小比较差异无统计学意义(P>0.05)。高分化患者碘浓度、NIC、k值、MVD明显高于低分化患者(均P<0.05)。无淋巴结转移患者肿瘤大小、碘浓度、NIC、k值及MVD均低于有淋巴结转移患者(均P<0.05)。Spearman相关性分析结果显示,碘浓度、NIC、k值与MVD及肺腺癌分化程度呈正相关(均P<0.05)。结论:双源CT标准化碘浓度、能谱曲线斜率与肺腺癌分化程度和淋巴结转移呈正相关,可作为术前判断肺腺癌分化程度及淋巴结转移的重要预测指标。
Abstract:
Objective:To analyze the relationship between dine concentration,Normalized iodine concentration(NIC),energy spectrum curve slope(k)detected by dual-source CT and differentiation degree,lymph node metastasis of lung adenocarcinoma.Methods:The clinical data of 297 patients with lung adenocarcinoma were retrospectively analyzed.Among them,71 were highly differentiated,132 were moderately differentiated,and 94 were in the poorly differentiated group; 164 had lymph node metastasis and 133 had no lymph node metastasis.All patients received dual-source CT examination before surgery and were confirmed by pathological examination after surgery.The differences of dual-source CT indicators(tumor size,iodine concentration,NIC,k value)in patients with different differentiation degree and lymph node metastasis were compared,and the correlation between iodine concentration,NIC,k value and microvessel density(MVD)was analyzed.Results:There was no statistically significant difference in tumor size among patients with different differentiation degree(P>0.05).The iodine concentration,NIC,k value,and MVD of well-differentiated patients were significantly higher than those of poorly-differentiated patients(all P<0.05).The tumor size,iodine concentration,NIC,k value and MVD of patients without lymph node metastasis were lower than those of patients with lymph node metastasis(all P<0.05).Spearman correlation analysis showed that iodine concentration,NIC,and k value were positively correlated with MVD and differentiation degree of lung adenocarcinoma(all P<0.05).Conclusion:The iodine concentration,NIC,and k value detected by dual-source CT are positively correlated with differentiation degree and lymph node metastasis of lung adenocarcinoma,and can be used as important predictors for judging differentiation degree and lymph node metastasis of lung adenocarcinoma before surgery.

参考文献/References:

[1] Sun GZ,Zhao TW.Lung adenocarcinoma pathology stages related gene identification[J].Math Biosci Eng,2019,17(1):737-746.
[2] 刘怡君,高 妍,李宝生.肺腺癌患者预后风险免疫信号识别TCGA数据资料分析[J].中华肿瘤防治杂志,2020,27(10):18-25.
[3] 郭油油,李咏梅,王静杰,等.双源CT能谱参数定性诊断甲状腺乳头状癌术后颈部转移淋巴结[J].中国医学影像技术,2019,35(5):669-672.
[4] 胡起立,宋黎涛,张 萍.双源CT检测的碘基值与肺癌疾病病理分型及临床疗效的关系研究[J].中国医学装备,2020,17(6):81-84.
[5] 陆 舜,虞永峰,纪文翔.2015年肺癌诊疗指南:共识和争议[J].解放军医学杂志,2016,41(1):1-6.
[6] 任东峰,孙国芳.六君祛痰解毒汤联合化疗治疗非小细胞肺癌疗效及对患者血管内皮生长因子的影响[J].陕西中医,2020,41(1):65-67.
[7] 王翠翠,耿利民.血清癌胚抗原对表皮生长因子受体基因突变非小细胞肺癌分子靶向治疗疗效的预测价值[J].陕西医学杂志,2020,49(7):834-837.
[8] Wang Q,Li M,Yang M,et al.Analysis of immune-related signatures of lung adenocarcinoma identified two distinct subtypes:Implications for immune checkpoint blockade therapy[J].Aging(Albany NY),2020,12(4):3312-3339.
[9] 陈志彪,王 东,刘 杰,等.早期肺腺癌患者预后及早期复发病理特征的研究[J].重庆医学,2019,48(2):186-190.
[10] 杨振宇,韦诗友,夏 粱,等.手术切除的N2期非小细胞肺癌预后影响因素探究[J].中国肺癌杂志,2020,23(1):21-26.
[11] 陆 运,马 腾,王 雷,等.早期非小细胞肺癌淋巴结转移规律及清扫方式研究进展[J].中国肺癌杂志,2019,22(8):50-55.
[12] 朱 攀,雷 蜜,高 波.肿瘤标志物及血管新生因子与结直肠癌患者临床分期及肿瘤转移相关[J].基础医学与临床,2019,39(1):59-62.
[13] 林国享,朱小东.肿瘤血管生成的促进因素及其在肿瘤发生发展中的作用研究进展[J].广西医学,2020,42(3):95-98,107.
[14] 顾 艳,苗重昌,袁 刚,等.肺癌双能量成像、微血管密度和血管内皮生长因子与淋巴结转移的关系[J].实用医学杂志,2018,34(6):151-154.
[15] 魏春燕.双源CT在小肠疾病中的临床诊断价值[J].中国数字医学,2020,15(2):141-144.
[16] 梁东海,郭艳江,李 祥,等.双源CT血管成像评估肺癌病变的价值[J].实用癌症杂志,2020,35(1):82-84.
[17] 闫海波.双源CT在鉴别诊断肾上腺乏脂肪腺瘤、小转移瘤中的应用价值[J].中国CT和MRI杂志,2020,18(2):110-112,116.
[18] 骆 孟,顾 艳,苗重昌,等.双源CT双能成像,微血管密度与实性肺腺癌分化程度和淋巴结转移的关系[J].实用医学杂志,2018,34(19):3242-3245,3249.
[19] 郭油油,李咏梅,王静杰,等.双源CT能谱参数定性诊断甲状腺乳头状癌术后颈部转移淋巴结[J].中国医学影像技术,2019,35(5):669-672.
[20] 杜军华,乔洪源,曹劲松.双源计算机断层扫描在肺癌病理类型及临床分期中的应用价值[J].癌症进展,2020,18(5):37-40.
[21] 孙亚娟,姜智允,尚乃舰,等.双源CT能量成像在评估非小细胞肺癌纵隔淋巴结转移中的应用价值[J].实用肿瘤学杂志,2019,33(6):531-535.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生计生科研基金资助项目(2016D098)
更新日期/Last Update: 2021-12-07