[1]王小芳,张利军.可溶性人髓系细胞触发受体1、可溶性血红蛋白清道夫受体、降钙素原表达水平对肝硬化合并自发性细菌性腹膜炎的诊断价值[J].陕西医学杂志,2021,50(12):1525-1527.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.014]
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可溶性人髓系细胞触发受体1、可溶性血红蛋白清道夫受体、降钙素原表达水平对肝硬化合并自发性细菌性腹膜炎的诊断价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1525-1527
栏目:
临床研究
出版日期:
2021-12-05

文章信息/Info

作者:
王小芳12张利军1
(1.神木市医院,陕西 神木 719300; 2.蓝田县人民医院,陕西 蓝田 710500)
关键词:
肝硬化 自发性细菌性腹膜炎 可溶性人髓系细胞触发受体1 可溶性血红蛋白清道夫受体 降钙素原
分类号:
R 657.31
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.014
文献标志码:
A
摘要:
目的:研究可溶性人髓系细胞触发受体1(sTREM-1)、可溶性血红蛋白清道夫受体(sCD163)、降钙素原(PCT)表达水平对肝硬化合并自发性细菌性腹膜炎(SBP)的诊断价值。方法:以肝硬化合并SBP患者49例为SBP组,以未合并SBP的肝硬化患者67例为对照组。对SBP组患者腹水培养病原菌进行分离鉴定。采用酶联免疫吸附(ELISA)法检测患者血清sTREM-1、sCD163、PCT水平。采用受试者工作特征(ROC)曲线评价sTREM-1、sCD163、PCT对肝硬化合并SBP的早期诊断效能。结果:SBP组49例患者腹水中分离出32株病原菌,病原菌检出率为65.31%。其中,革兰阴性菌18株(56.25%),以大肠埃希菌(8株)和肺炎克雷伯菌(7株)为主; 革兰阳性菌14株(43.75%),以金黄色葡萄球菌(6株)为主。SBP组患者血清sTREM-1、sCD163、PCT水平明显高于对照组(均P<0.001)。ROC曲线分析显示,患者血清sTREM-1、sCD163、PCT对肝硬化合并SBP均具有较高的诊断效能,且三项联合对肝硬化合并SBP的诊断效能明显高于单项(均P<0.001)。结论:肝硬化合并SBP患者血清sTREM-1、sCD163、PCT表达水平明显升高,可作为早期诊断标志物。

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更新日期/Last Update: 2021-12-07